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Biomedical subjects

J G Meran

Publications and source records attributed to J G Meran.

At least 19 recordsLinked to original sources
PubMed1992

[Quality of life--demands and reality as a medical parameter versus quality of life as individual reality].

Quality of life (QL) is a term, whose definition extends beyond scientific methods. Even the most accurate description will only be able to represent a part of the reality due to the proviso of only a limited view. For that reason the abandonment of this term, described as "utopical" and "principally remaining in dissent", was called for. This could be countered by the possibilities to use QL as a therapeutic aim, as well as an aid towards finding an individual indication. Alone the demand staged by QL, to take the individuality seriously, and to be the motor for patient oriented medicine, make this term valuable. The definition itself will remain a called instruments have been developed and tuned, their evaluation has not yet been concluded. The acceptance of QL-registration within clinical studies is low, since the individual integration of values compared to the biometric difficulties can hardly be generalized. The aims of QL-research are: the individual focus on the field of projection of QL; a motivation-oriented mode of record; the involvement of QL-registration in form of information and accompaniment; adequate modular techniques including dialogical methods (nondirective interviews); the establishment of a QL-anamnesis towards an extension of the clinical picture; the observance of a possible conflict of roles, the danger of linguistic inaccuracies and misunderstandings, the consideration of a person's privacy.

Ethics, Medical↗
PubMed1992

[Differential diagnosis of peptic ulcer].

Although new pathogenetic findings of peptic ulcers have been detected, there still remain some open questions. Accurate anamnestic evaluation will find out risk factors as cigarette-smoking, stress and therapy with nonsteroidal antiinflammatory drugs (NSAIDs), and will be helpful in differential diagnosis. Endoscopy is the diagnostic means of choice, and enables to easy helicobacter pylori detection. Since some gastric ulcers are actually carcinomas, it is absolutely necessary to obtain multiple biopsies. The Zollinger-Ellison syndrome and symptoms of other rare diseases of the upper intestine are discussed.

Diagnosis, Differential↗
PubMed1992

[Helicobacter pylori. New apsects in the pathogenesis of peptic ulcer disease].

Antral gastritis and peptic ulcer disease are closely related to gastric Helicobacter pylori (HP) infection. HP possesses several pathogenic features which point to a causal role of HP in the development of gastroduodenal lesions. It is now generally accepted that HP causes type B gastritis, while its role in the pathogenesis of peptic ulcers is still unsolved. According to the classical ulcer concept, peptic ulceration is the result of an imbalance between protective mucosal mechanisms and aggressive digestive factors. The identification of HP does not disprove this concept, however, HP has to be added as a major pathogenic factor.

Gastric Mucosa↗
PubMed1992

[Methodology and clinical significance of intragastric long-term pH measurement].

Intragastric long-term pH-metry is a suitable method of assessing gastric acidity under conditions of real life. The pH-metry system consists of three components: pH electrode, solid state recorder, and data analyzing system. Combined glass electrodes are recommended for gastric pH studies. Up to now, there are no generally accepted normal values in gastric pH-metry and thus data analyzing is not uniformly standardized. Intragastric pH-metry is the method of choice for monitoring of antisecretory treatment. This method enables the recognition of non-responders and improves dosing of antisecretory drugs. The prognostic value of gastric pH-metry in the assessment of acid-related diseases, if any, has still to be defined.

Gastric Acidity Determination↗
PubMed1992

[Complications of peptic ulcer].

The complication rate of peptic ulcer disease is 2 to 5% a year. Hemorrhage occurs four times more often than perforation and penetration. High age and the use of nonsteroidal antiinflammatory drugs (NSAID) are the most important risk factors. The incidence of rebleeding is twice as high after a first complication. About 15 to 30% of bleeding patients die because of this complication. Endoscopy is the means of choice in diagnosis and primary therapy. Gastric retention and vomiting of stale food are typical symptoms of gastric outlet obstruction.

Humans↗
PubMed1992

[Abortion in the penal code].

Before discussing the change of legal norms it is necessary to know the actual law. The paper shows the West-German penal code and it's application in respect of the pregnant women, the physician and third persons.

Abortion, Legal↗