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Biomedical subjects

J G Morrison

Publications and source records attributed to J G Morrison.

At least 37 records · Page 2Linked to original sources
PubMed1981

Familial chronic mucocutaneous candidiasis successfully treated with oral ketoconazole.

A father and son, both suffering from chronic mucocutaneous candidiasis, were successfully treated with oral ketoconazole, a water-soluble imidazole compound. No toxic side-effects occurred during treatment. Treatment was given for about 8 months with diminishing does of ketoconazole. The disease cleared completely about half-way through the course of treatment and did not relapse within 1 month of discontinuing the drug. The only immunological abnormality was a depression in vitro of neutrophil chemotaxis. This became normal during therapy and was regarded as being a result of the disease and not as its cause.

Administration, Oral↗
PubMed1980

A distinctive skin eruption following small-bowel by-pass surgery.

Crops of distinctive skin lesions appeared after jejuno-ileal by-pass surgery for morbid obesity in three patients. They consisted mainly of large numbers of macules on the extremities, of vague outline and with a tendency to central pustulation and necrosis. Severe arthralgia and myalgia preceded the skin lesions, which histologically showed a dense neutrophil leukocytic infiltrate, nuclear debris, and fibrin deposition around blood vessels in the dermis.

Adult↗
PubMed1979

Rheumatoid arthritic syndrome after chikungunya fever.

An outbreak of chikungunya fever which occurred during April 1977 among a group of high-school children from Pretoria after a visit to the northern Transvaal bushveld is reported. Some of the adults who accompanied the pupils also contracted the disease. The adults suffered more severely from the chronic arthritic form of the disease than did the children. In some cases the episodic polyarthritis was still present 18 months after the onset of the disease. Rheumatoid factors in low titre could be demonstrated in the circulation of patients with longstanding symptoms.

Adolescent↗
PubMed1978

Treatment of eczema with cyclophosphamide and azathioprine.

Nine patients with eczema were treated with the immunosuppressive drugs cyclophosphamide and azathioprine. In all patients the eczema was severe and incapacitating and had not responded satisfactorily to systemic and topical corticosteroid therapy. The eczema improved in all patients and systemic corticosteroids, which had resulted in undesirable side-effects, could be decreased or stopped. Leukopenia was not necessary for achieving clinical improvement. Several months of treatment were needed to obtain significant improvement in the eczema and long term remissions followed cessation of therapy.

Adrenal Cortex Hormones↗
PubMed1978

Erythrokeratolysis hiemalis--keratolytic winter erythema or 'Oudtshoorn Skin'. A new epidermal genodermatosis with its histological features.

A new autosomal, dominantly inherited epidermal disorder is described in which a spreading dissection of the stratum corneum with redness of the palms and soles occurs as a result of a centrifugal necrobiosis of the Malpighian layer below it. Iis is seen characteristically in winter. In extensive cases the limbs and trunk are affected with gyrate scaling erythemas.

Child, Preschool↗
PubMed1977

Keratolytic winter erythema or 'oudtshoorn skin': a newly recognized inherited dermatosis prevalent in South Africa.

A hitherto undescribed inherited dermatosis, traceable to certain 19th-century inhabitants of Oudtshoorn, CP, has been transmitted as an autosomal dominant to a large number of their present-day descendants. The disease consists of intermittent and recurrent centrifugal peeling, with redness, of the palms and soles in particular. In more severe cases similar patches are found extending up the limbs to the buttocks and the trunk generally. The inconvenience is usually moderate, but it may be incapacitating. Some temporary relief, but so far nothing permanent, can be offered through treatment.

Adolescent↗
PubMed1977

Juvenile elastoma and osteopoikilosis (the Buschke--Ollendorff syndrome).

Sixteen patients from seven different families with the Buschke-Ollendorff syndrome have been studied. Osteopoikilosis was found in two-thirds of the patients radiologically examined and all but two had skin involvement. The predominant clinical pattern consisted of grouped skin coloured papules and discs that were distributed asymmetrically and which usually had presented at an early age. The skin lesions showed the characteristic histological changes of juvenile elastoma which, it is suggested, is the specific dermatological abnormality of the Buschke-Ollendorff syndrome.

Adult↗
PubMed1976

Cutaneous ectopic schistosomiasis.

Two cases of cutaneous schistosomiasis due to ectopic ova have recently been seen. Both patients presented with abdominal papular lesions, which were found on biopsy to contain schistosoma ova. To reach these abdominal sites mature worms probably migrate from the portal circulation to the paraumbilical veins, where they anastomose with veins of the caval system.

Adult↗
PubMed1976

Sarcoidosis in a child, presenting as an erythroderma with keratotic spines and palmar pits.

A case of sarcoidosis with generalized erythroderma, exfoliation and micropapule formation in a 6-year-old boy is presented. Follicular spiny keratoses, resembling those seen in pityriasis rubra pilaris, and palmo-plantar pitting were among the other extraordinary features in this case. The epidermis overlying the widespread sarcoid granulomata showed parakeratosis, lymphocytic infiltration and degeneration of the basal layer.

Child↗
PubMed1975

Exogenous ochronosis and pigmented colloid milium from hydroquinone bleaching creams.

An outbreak of ochronosis and colloid milium is described after the use of strong hydroquinone bleaching creams. These phenomena developed only after a few years, and took place when the melanocytes had overcome the bleaching influence. Sun-exposure and thorough inunction of the cream were required for the more advanced changes. Analogous changes have been seen when the skin is exposed to certain crude fuels in individuals working in the sun, and phenolic components in the fuels are suspected. The study presented here covers the clinical, histological, histochemical, electron microscopical and pathogenetic features as seen in thirty-five cases of hydroquinone damage to the dermis in South Africa.

Adult↗