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Biomedical subjects

J G Paty

Publications and source records attributed to J G Paty.

10 recordsLinked to original sources
PubMed1994

Running injuries.

Overuse is the primary culprit in most running injuries, with biomechanical factors playing a much smaller role. A review of some of the most common and recalcitrant injuries in adults and adolescents is presented. Discussion of the pathophysiology of tendon injuries, stress fractures of the lower extremities, and apophysitis in adolescents is undertaken, and treatment strategies are proposed. Additionally, non-musculoskeletal events that may be related to a musculoskeletal injury such as exercise-associated amenorrhea and chronic fatigue or depression are reviewed. That running may promulgate osteoarthritis is still controversial. Most studies are limited by their retrospective design. However, the preponderance of data gives insufficient credence to the idea of osteoarthritis as a complication of long-distance running. With regard to treatment, nonsteroidal anti-inflammatory drugs appear to play little or no effective role in the management of running injuries.

Athletic Injuries↗
PubMed1988

Diagnosis and treatment of musculoskeletal running injuries.

In summary, musculoskeletal injuries occur in at least 60% of runners. Selfinduced training error accounts for the majority of running injuries. A review of the runner's mileage, training techniques, biomechanical examination, and shoes will provide clues to the accurate diagnosis and treatment. In most cases it is not correct to categorically advise the runner to stop running, since a modification of running techniques will usually get him or her painlessly "back on the road." The result will be a grateful patient.

Athletic Injuries↗
PubMed1984

Adolescent running injuries.

Nineteen teenagers between the ages of 13 and 18 years who had been running an average of 23.8 miles a week were attended for 25 musculoskeletal injuries. Diagnoses were similar to those seen in adults. Over 70% of the injuries involved the knee or leg. Girls had more leg injuries. All stress fractures occurred in the females despite their having less than one-half the weekly mileage of the boys (12 vs. 32 miles). Knee injuries were more common in boys. Over two-thirds of the injuries resulted from a training error. Methods for evaluation, treatment, and prevention of adolescent running injuries are discussed.

Adolescent↗
PubMed1976

Delayed hypersensitivity skin testing for assessing anergy in the mid-south.

Although skin testing with ubiquitous antigens is widely employed to assess delayed hypersensitivity, little is known about the effect of geographic location on the frequency of skin test reactions to given antigens. To assess skin test reactivity in the mid-South, 82 hospitalized patients and 68 normal controls had skin tests with six antigens: histoplasmin, mumps, tuberculin purified protein derivative (PPD), Candida, Trichophyton, and streptokinase-streptodornase. Ninety-five percent of normal and 79% of hospitalized subjects without immunologically related disease reacted to at least one of the antigens. A high rate of anergy was found in a clinical setting of debilitation and malnutrition. If subjects in poor condition also were excluded, 93% of hospitalized patients reacted to at least one antigen. Rates of reactivity increased with higher concentrations of antigen. To assess anergy in the mid-South, it is recommended that patients be skin tested initially with histoplasmin, mumps, and PPD antigens. If the patient does not react to any of these, streptokinase-streptodornase and Candida albicans (Dermatophytin "O") should be applied.

Antigens↗
PubMed1975

Impaired cell-mediated immunity in systemic lupus erythematosus (SLE). A controlled study of 23 untreated patients.

Cell-mediated immunity was evaluated in 23 patients with systemic lupus erythematosus (SLE) prior to therapy and in 23 control subjects. The patients with SLE who had moderate to severe disease activity had significantly fewer positive delayed skin tests to streptokinase-streptodornase (SK-SD) and Candida than the control subjects, and a higher frequency of anergy than either the control subjects or the patients with mild SLE. Significant impairment of lymphocyte transformation to all common antigens tested was found in patients with SLE as compared to both normal subjects and control subjects with disease. Phytohemagglutinin response was reduced in patients with SLE as compared to normal subjects but not to the control subjects with disease. Lymphocyte transformation responses to SK-SD and Candida were also significantly lower in patients with moderate to severe SLE as compared to patients with mildly active SLE. Primary immune response to keyhole limpet hemocyanin (KLH) was impaired in patients with SLE as measured by lymphocyte transformation and total KLH antibody, but not 2-mercaptoethanol resistant antibody. The data indicate defective T-cell function in SLE, and suggest that the impairment relates in part to disease activity.

Adolescent↗