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Biomedical subjects

J G Pous

Publications and source records attributed to J G Pous.

At least 37 records · Page 2Linked to original sources
PubMed1983

Legg-Calvé-Perthes disease. Histochemical and ultrastructural observations of the epiphyseal cartilage and physis.

UNLABELLED: Biopsy specimens of the lateral aspect of the femoral head and neck were obtained from five children with Legg-Calvé-Perthes disease and were studied using histochemistry and electron microscopy. Beneath the normal articular cartilage there was a thick zone of hyaline (epiphyseal) cartilage containing sharply demarcated areas of hypercellular and fibrillated cartilage with prominent blood vessels. The fibrillated cartilage was strongly positive to alcian blue, weakly positive to periodic acid-Schiff, and positive to aniline blue. The interterritorial matrix in the hypercellular areas was weakly positive to both alcian blue and periodic acid-Schiff. Ultrastructural examination of these areas revealed many irregularly oriented large collagen fibrils and variable amounts of proteoglycan granules. These results suggest that in the fibrillar areas there are: (1) a high proteoglycan content, (2) a decrease in structural glycoproteins, and (3) a different size of collagen fibrils from that of normal epiphyseal cartilage. The hypercellular areas had a decrease in proteoglycans, glycoproteins, and collagen. The lateral physeal margin was often irregular, with a marked reduction of collagen and proteoglycan granules, and contained numerous large lipid inclusions. CLINICAL RELEVANCE: The abnormal areas in the epiphyseal cartilage of patients with Legg-Calvé-Perthes disease have different histochemical and structural properties from normal cartilage and from fibrocartilage. This suggests that the disease could be a localized expression of a generalized, transient disorder of epiphyseal cartilage that is responsible for delayed skeletal maturation. The cartilage lesions are similar to those seen in the vertebral plates in patients with juvenile kyphosis. Whether the epiphyseal cartilage abnormalities are primary or are secondary to ischemia remains uncertain; however, it appears that the collapse and necrosis of the femoral head could result from the breakdown and disorganization of the matrix of the epiphyseal cartilage, followed by abnormal ossification.

Cartilage, Articular↗
PubMed1982

[Epiphyseal vascularization during growth. Study preliminary to transplantation].

A study was conducted of 50 cadavers in children and 25 immature dogs to discover more precisely the vascularization of the lower end of the femur and the iliac crest. It was concluded that it is possible to transplant these epiphyses with anastomosis of three pedicles in the same line. It was also concluded that the vascularisation differs before and after the formation of the bony epiphyseal nucleus. The cartilaginous canals which preclude the vascularisation of hyaline cartilage, the formation of the bony nucleus and the nutrition of the germinal layers of the growth plate are described.

Animals↗
PubMed1979

[Is treatment of C.D.H. by progressive reduction by traction still advisable? (author's transl)].

The authors analyse the results that they have obtained in the treatment of C.D.H. either by conservative or surgical methods. The prevention of osteochondritis remains the main worry. However traction leads to long-lasting immobilization and sometimes it is not sufficient. The authors think that osteochondritis may be related to hyper-pressure on the femoral head or to lesions of the vascular pedicle and that in some cases shortening of the femur or tenotomies may allow a decrease of the plaster cast period. The indications on capculotomy, rotation osteotomy, salter osteotomy are discussed. It is concluded that the periods of traction and plaster cast immobilization should be lessened as much as possible.

Age Factors↗
PubMed1978

Neonatal surgery in clubfoot.

Neonatal surgery for clubfoot is conducted according to the following rules: One must work as close to the lesions as possible. It is important to avoid going beyond abnormal tissues. Dissection should be precise and economical. Opening of Lisfranc's joint or sectioning of the medial ligament must be avoided. One must operate with maximal accuracy. All areas of fibrosis must be excised, but care must be taken not to enter the interarticular space. If a bone deformity is present, one must accept an incomplete correction. One must act as soon as possible. This is the inverse of classic management in which orthopedic surgery was postponed. We prefer early surgery followed by intensive postoperative rehabilitation.

Cicatrix↗
PubMed1975

[Lymphoid hyperplasia of the colon].

Report of the cases of two infants presenting with lymphoid hyperplasia of the colon, occuring after intestinal obstruction associated with enterocolitis. In one case, it was histologically proved. These cases emphasize the problem of the real meaning of lymphoid hyperplasia of the colon, as well as the meaning of its relationships with enterocolitis. Evolution was benign and it seems that there is no peculiar symptomatology.

Barium Sulfate↗
PubMed1975

[Orthopedic reduction of scoliosis by Maguelone's technic. Indications and first results].

The authors describe an original technique for rapid closed reduction of scoliosis (Maguelone technique). It is based on mild distraction in suspension associated with derotation without pressure points. It is painless and efficient. In 50 cases it was followed by a conservative treatment using plaster casts. In 15 other cases it was the first stage of a surgical treatment of the deformity.

Braces↗