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Biomedical subjects

J G Silver

Publications and source records attributed to J G Silver.

16 recordsLinked to original sources
PubMed1998

Drug-induced gingival enlargements.

There are many types of gingival enlargements which vary according to the etiologic factors and pathologic processes that produce them. The most common drug-induced gingival enlargement is associated with Dilantin (phenytoin). Cyclosporin and calcium channel blockers, which are increasingly used for some cardiac diseases, immunosuppression and autoimmune disorders, also cause gingival enlargement. The term "gingival hyperplasia" is an inappropriate term because enlargement is not the result of an increase in the number of cells, but rather an increase in extracellular tissue volume. This paper presents a detailed description of various drug-induced gingival enlargements, including the clinical appearance, microscopic presentation, pathogenic mechanisms and treatment options.

Anticonvulsants↗
PubMed1997

Nonsteroidal anti-inflammatory agents: potential modifiers of periodontal disease progression.

The most recent studies of NSAIDs as potential modifiers of periodontal disease progression are reviewed. These studies indicate that NSAIDs have the ability to alter or control the progression of periodontal disease. Reductions in gingival inflammation and in bone loss have been observed following the administration of various NSAIDs. In some cases, bone gain has been achieved. More research is required to determine the possible long-term side effects associated with the chronic usage of NSAIDs, as well as to achieve consensus on the most effective drug for the control of periodontal disease. Until this occurs, and this application of NSAIDs receives government approval, the use of these drugs to control periodontal disease is not recommended.

Administration, Oral↗
PubMed1996

Early-onset periodontitis associated with Weary-Kindler syndrome: a case report.

Weary-Kindler syndrome is a rare and poorly understood genetic disorder that has manifestations of both epidermolysis bullosa and poikiloderma congenitale. There are approximately 70 cases documented in the past 40 years but no cases appear in the dental literature, although dental findings have been discussed superficially in dermatological and pediatric publications. This case reports on the periodontal findings and treatment for a 16-year-old female diagnosed with the syndrome. Early exfoliation of deciduous teeth, severe periodontal bone loss around many permanent teeth, and fragile bleeding gingiva were key features. Microbiological testing revealed an absence of Actinobacillus actinomycetemcomitans and low levels of other commonly accepted periodontal pathogens. Tests for inflammation, including AST and elastase, were positive prior to therapy and greatly decreased after mechanical root instrumentation. A beneficial effect of non-surgical periodontal therapy was observed in the short-term follow-up.

Adolescent↗
PubMed1996

Periodontal diseases affecting children and young adults.

There is a group of periodontal diseases affecting children and young adults that is characterized by onset prior to age 35, often with a rapid rate of periodontal destruction. Although a wide variation in patterns of presentation exist, these diseases can be described under the broad categories of (a) early onset periodontitis (juvenile periodontitis), (b) necrotizing ulcerative gingivitis/periodontitis, (c) periodontitis associated with systemic diseases. A discussion of each of these categories is followed by two case reports which illustrate possible clinical presentations of these diseases.

Adolescent↗
PubMed1990

The influence of frequent ingestion of acids in the diet on treatment for dentin sensitivity.

For many patients with severe and persistent pain from dentin sensitivity, therapeutic interventions often produce unsatisfactory results. Eighteen patients with persistent dentin sensitivity following a two-month clinical trial of a desensitizing dentifrice and a two-week treatment of four applications of a topical fluoride varnish participated in post-hoc evaluation of the association between the frequency of acid ingestions in the diet and the persistence of pain. A specific food frequency assessment was performed and tested for association against longitudinal, clinical and subjective patient assessments. There was a negative association (r = 0.49) between the frequency of ingestion of specific acid foods and beverages and the persistence of dentin sensitivity. Findings suggest that nutritional counselling should be part of the treatment offered for patients with these problems.

Acids↗
PubMed1985

Oral health in a long-term care institution equipped with a dental service.

The oral health and medico-dental status of 250 mostly elderly residents of a long term care institution were assessed by examination and a review of medical records. In addition, attitudes to dental care, dental experiences, and demands for care were solicited from those who could participate in an interview. There were no dental complaints from 70% of those interviewed. The complaints most frequently reported were difficulties with mouth dryness, hygiene, and chewing. Natural teeth remained in at least one jaw in 30% of the 245 residents examined. Dental caries was present in 78% of this dentate group, with coronal and root lesions equally prevalent. Gingival bleeding was also common in this group and 29% had deep periodontal pockets. Nearly 50% of the mandibular dentures and 25% of the maxillary dentures examined were inadequate. Mandibular dysfunction occurred in 25% of the population and was more frequent in the dentate group. Oral mucosal pathoses were rare. No correlation was found between the systemic health and the oral health of the residents. There was a need to improve the oral hygiene of most of those examined. Less than 20% of the denture wearers would have benefitted from treatment and 10% of those with defective dentures were considered unsuitable for treatment. In contrast, 60% of those with natural teeth required restorations and 36% needed one or more teeth removed. Very few urgent needs were seen. An inter-examiner accumulative inconsistency of 11% was measured between the three examiners, and a third of the assessments made of periodontal status were contradictory.

Aged↗
PubMed1979

Experimental transient bacteraemias in human subjects with clinically healthy gingivae.

Thirty-six subjects with no evidence of clinical gingival inflammation underwent a standardized toothbrushing procedure. Blood specimens, obtained from a vein in the antecubital fossa during the last 30 seconds of brushing, were cultured under aerobic and stringent anaerobic conditions. Three subjects exhibited detectable bacteraemias, Propionibacterium sp. being isolated from two of the subjects, while Actinomyces sp., Streptococcus sanguis and Streptococcus mitis were isolated from the third. The implications of these results are discussed.

Actinomyces↗
PubMed1977

Experimental transient bacteraemias in human subjects with varying degrees of plaque accumulation and gingival inflammation.

Ninety-six subjects were assigned to one of four groups according to severity of gingival inflammation and bacterial plaque accumulation on the teeth. Following a standardized toothbrushing procedure, blood specimens from a vein in the antecubital fossa were cultured under aerobic and stringent anaerobic conditions. The percentage of positive cultures increased significantly with increasing severity of gingival inflammation, as did the number of species of organisms isolated. Thirty different microbial species indigenous to the oral cavity, including many strict anaerobes, were recovered. The study has implications for standards of oral health which might be considered necessary in patients with congenital or acquired endocardial defects or cardiovascular prostheses.

Adolescent↗
PubMed1975

The prevalence of periodontal disease in a selected dental population.

Sixty-five dental personnel, who presented for voluntary examination at a periodontal screening center, were assessed for plaque accumulation, gingival soft tissue changes, gingival recession and pocket depth. The relationship of these parameters to one another and to a variety of oral hygiene techniques was analyzed. Positive correlations were found between pocket depth and soft tissue changes and also between some of the parameters and use of an interdental stimulator or an oral irrigating device. The nature of the results is discussed.

Adult↗