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Biomedical subjects

J G Stephen

Publications and source records attributed to J G Stephen.

7 recordsLinked to original sources

Changes in esophageal function after vertical banded gastroplasty as demonstrated by esophageal scintigraphy.

BACKGROUND: The effects of surgery for morbid obesity on the function of the upper gastrointestinal (GI) tract are of interest to bariatric surgeons. This study was undertaken to determine any changes in esophageal function, following vertical banded gastroplasty (VBG) in morbidly obese patients, as detected by esophageal scintigraphy. METHODS: Ten consecutive morbidly obese patients (six female and four male) underwent preoperative esophageal scintigraphy and upper GI endoscopy. These investigations were repeated 12 months after VBG to coincide with expected appreciable weight reduction. The results were tabulated together with body mass indices, crude weights and percentage excess weight lost. RESULTS: Before VBG one patient gave a history of mild heartburn, one had mild dyspepsia and the remaining eight patients had no GI symptoms. No patient had a hiatus hernia or endoscopic evidence of reflux esophagitis. Preoperatively all patients had abnormal scintiscans. The abnormalities were esophageal retention (all) and intraesophageal reflux (five out of 10 patients). Gastroesophageal reflux was not identified in any patient. Postoperatively scintiscans were normal or improved in six out of 10 patients and unchanged in four out of 10 patients. In three patients the scans were normal and three showed overall improvement in esophageal function, although in one of these latter patients gastroesophageal reflux was observed. CONCLUSIONS: In this series of morbidly obese patients, esophageal function as assessed by scintigraphy was abnormal. Following VBG it improved in six out of 10 patients and was unchanged in four out of 10. However, in one patient, who had shown an overall improvement in esophageal function, gastroesophageal reflux was demonstrated when it had not been seen preoperatively. This was asymptomatic. Thus, adverse changes in esophageal function after VBG were uncommon.

Adolescent↗

Papillary thyroid carcinoma associated with ulcerative colitis.

A case is reported of papillary thyroid adenocarcinoma with cervical lymph node metastases in a young man who had presented earlier with severe total ulcerative colitis. The aetiological factors in the pathogenesis of papillary thyroid carcinoma are briefly reviewed and an association between this neoplasm and ulcerative colitis is suggested.

Adenocarcinoma, Papillary↗

Relationship between hydrogen ion concentration and flow of gastric juice during inhibition of gastric secretion in the cat.

1. The normal relationship between the [H+] and rate of flow of gastric juice was determined in conscious cats prepared with cannulated gastric fistulae. Gastric secretion was monitored during stimulation with pentagastrin, insulin and histamine. 2. [H+] rose asymptotically with the flow of gastric juice. This relationship was quantified by applying the data to the integrated form of the Fick equation for diffusion, a graphical plot of log [H+] vs. 1/flow. The calculated relationships were similar for gastric secretion stimulated by pentagastrin, insulin and histamine, and were used to define the normal relationship between gastric [H+] and flow. 3. Significant inhibition of pentagastrin-stimulated gastric secretion with the histamine H2-receptor antagonists, metiamide and cimetidine, atropine or somatostatin did not alter the normal relationship between [H+] and flow; the [H+] observed fell within the normal range observed at that flow rate in the presence of pentagastrin alone. Similarly, inhibition of insulin-stimulated secretion with metiamide, did not alter the normal relationship between [H+] and flow of gastric juice. 4. These data provide evidence that histamine H2-receptor antagonists, atropine and somatostatin all act to reduce the primary rate of acid secretion and do not influence the [H+] per se, either by interfering with back-diffusion of H+, or by changing the proportions of a non-parietal component of gastric secretion added to the parietal H+ component.

Animals↗

Endoscopic appearances and histological changes in ulcer-associated duodenitis.

A simple system of grading the endoscopic appearances of duodenitis is described. There was a good association between the degree of duodenitis recorded using this method and that obtained from a histological grading system in a group of duodenal ulcer patients and a group of dyspeptic patients with no endoscopic evidence of duodenitis. Endoscopic assessment is recommended as a reliable guide to the presence of duodenitis. After 1 month of treatment with cimetidine there was a significant improvement in the endoscopic duodenitis scores of a group of 17 duodenal ulcer patients. In 16 of these patients there was complete ulcer healing. Duodenitis can be a manifestation of chronic duodenal ulcer disease. In the absence of ulceration, the endoscopic diagnosis of duodenitis is of value in the recognition of patients with this condition.

Adult↗

Necrotizing 'sarcoidal' angiitis and granulomatosis of the lung.

A case of necrotizing sarcoid angiitis and granulomatosis (NSG) presenting as a peripheral lung 'tumour' in a 63-year-old man is recorded, and the clinical and pathological features are compared with those of Liebow's original cases. Resection may be avoided if the diagnosis is made by biopsy as the disease is possibly steroid responsive and the prognosis appears favourable. The aetiology is obscure but an immune disturbance is suspected.

Arteritis↗