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Biomedical subjects

J G Tye

Publications and source records attributed to J G Tye.

5 recordsLinked to original sources
PubMed1984

Intraocular pressure after intracapsular cataract extraction.

We studied the incidence of postoperative intraocular pressure elevations in 42 patients following intracapsular cataract extraction with alpha-chymotrypsin (1:5,000) and noted 17% to develop pressures greater than 30 mm Hg and 38% greater than 24 mm Hg within a 48-hour time interval. Additionally, we studied the effect of a single immediate postoperative instillation of timolol maleate 0.5%; this was associated with a slight reduction of intraocular pressure at the three- and six-hour time intervals, but did not eliminate the pressure spikes.

Aged↗
PubMed1977

Pancreatic and salivary amylase activity in undernourished Colombian children.

Amylase activities were quantitated in secretions of marginally and severely malnourished Colombian children. In young children with a mean age of 21 months, the relative pancreatic and salivary amylase isozyme activities of urine were significantly changed in marginally malnourished children compared to normal children. There was a relative increase in salivary and decrease in pancreatic amylase activity in the undernourished children and total amylase activity was somewhat decreased. Amylase activity in saliva and tears was significantly lower in these malnourished children. Older children who were more severely malnourished had significantly lower amylase activity in their sera and tears. Thus marginal and severe malnutrition affects the production of amylase by the pancreas and salivary glands of young children distinctly. It significantly suppresses amylase activity in tears, saliva, and serum.

Aminopeptidases↗
PubMed1976

Differential expression of salivary (Amy1) and pancreatic (Amy2) human amylase loci in prenatal and postnatal development.

The age-dependent development of alpha-amylase expression in utero and during the first two years of life is reported. Separation of salivary and pancreatic amylase isozymes in a discontinuous buffered sheet polyacrylamide electrophoretic system, with subsequent densitometry, provides a reliable semiquantitative method of estimating the proportions of salivary and pancreatic amylases in urine and amniotic fluid samples. In the newborn the predominant amylase isozymes seen in the urine are of salivary origin. As the child ages the level of amylase in the urine rises and an increase in the proportion of pancreatic amylase isozymes occurs. Amniotic fluids of late first and early second trimester pregnancies contain salivary isozymes. None of the amniotic fluid samples examined has pancreatic amylase isozymes. These data reflect a differential development of the expression of the two amylase approaches adult levels by 16 months of age. Conversely, the salivary (Amy1) locus is expressed as early as 18 weeks of gestation and remains relatively constant with but a small increase in salivary amylase (units/ml) activity during early development, as the total amylase activity approaches adult values.

Age Factors↗