Biomedical subjects
Publications and source records attributed to J G Wigmore.
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Nine female and 21 male alcohol-free subjects introduced 10 mL of diluted gin (20% v/v alcohol) into their mouths under two conditions. The subjects either rinsed the alcohol for 10 s and then expectorated or immediately swallowed. They then provided breath samples into an Intoxilyzer 5000 at 5 and 10 min postadministration for both conditions. The mean Intoxilyzer results plus or minus one standard deviation (n = 30) were 0.091+/-0.051; 0.036+/-0.027; 0.014+/-0.011, and 0.004+/-0.006 g/210 L for 5 min after rinsing, 5 min after swallowing, 10 min after rinsing, and 10 min after swallowing, respectively. The percentages of times that mouth alcohol was correctly detected by the Intoxilyzer 5000 were 90%, 66%, 62% and 30% for these conditions, respectively. Ten minutes after the introduction of alcohol into the mouth, 63% of the Intoxilyzer results were > 0.010 g/210L after rinsing compared with only 7% after swallowing. The mouth alcohol effect is greater for rinsing than for swallowing alcohol.
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Two case reports of the dilution by intravenous fluids of blood samples collected for medicolegal alcohol analysis are presented. The forensic significance of the findings is discussed.
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Ethanol concentrations in serum (SAC) and whole blood (BAC) were determined for 235 subjects by a headspace gas chromatographic method. The SAC:BAC ratios ranged between 1.04 and 1.26. The mean was 1.14, and the normal distribution had a standard deviation (SD) of 0.041. When a conversion (division) factor for SAC to BAC of 1.18 (mean + 1 SD) was used, 84% of estimated BACs were less than that measured; the remaining estimates differed by less than 7 mg/dL. An SAC greater than 100 mg/dL reliably indicated a BAC of more than 80 mg/dL. Ethanol concentrations in blood cells (CAC) were similarly determined for 167 of these subjects. The CAC:BAC ratios ranged from 0.66 to 1.00 and had a mean of 0.865 and a negatively skewed normal distribution with an SD of 0.065. When a conversion (division) factor for CAC to BAC of 0.93 (mean + 1 SD) was used, 89% of estimated BACs were less than that measured; the remaining estimates differed by less than 8 mg/dL. A CAC greater than 80 mg/dL reliably indicated a BAC of more than 80 mg/dL. The CAC is useful in forensic practice when either blood or serum is not available.