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Biomedical subjects

J G de Visscher

Publications and source records attributed to J G de Visscher.

At least 19 recordsLinked to original sources
PubMed2003

[A white lesion of the oral mucosa: leukoplakia?].

In three patients, two men aged 50 and 44 years and a woman aged 56 years, an apparently identical white lesion of the oral mucosa was found. The first patient appeared to have an irritation due to vigorous toothbrushing, which disappeared after reducing the brushing frequency and using a soft brush, the second patient had a lichen planus, for which a wait and see policy was adopted, and the third patient had verrucous hyperplasia with dysplasia which was treated by CO2-laser evaporation. Oral leukoplakia occurs frequently together with other white lesions. Leukoplakia is a diagnosis by exclusion and the term should be used as a clinical diagnosis only. When a biopsy is taken, the term leukoplakia is replaced by the diagnosis obtained histologically. About 5% of leukoplakias progress to cancer in a mean observation period of 5 years. Sufficient knowledge of the nomenclature and clinical characteristics of oral white lesions may contribute to the prevention of malignancies and unnecessary referral to a medical specialist.

Adult↗
PubMed2001

Surgical treatment of Graves orbitopathy: a modified balanced technique.

Surgery has a definite place in the treatment of the exophthalmos in Graves orbitopathy. Thirty-two patients with Graves orbitopathy were operated on. Twenty patients received a three-wall orbital decompression. Five patients received a two-wall orbital decompression with lipectomy and seven patients underwent a two-wall orbital decompression combined with an advancement osteotomy of the supra-, lateral- and infra-orbital rim and a lipectomy. In cases with Hertel values less than 25 mm, the two-wall orbital decompression with removal of orbital fat. and in cases with Hertel values more than 25 mm, the two-wall orbital decompression with lipectomy and an advancement osteostomy of the supra-, lateral- and infraorbital rim is the treatment of choice.

Adolescent↗
PubMed2000

[Team approach in maxillofacial oncology].

The most frequent malignant tumour in the head and neck region this area is the squamous cell carcinoma of the upper aerodigestive tract. In the Netherlands the incidence of these tumours is low, about 2000 new cases a year. Multidisciplinary treatment of these tumours is mandatory because of the extension of the lesion in the area of other disciplines. The variety of diagnostic and therapeutic possibilities and the supportive care ask for a multidisciplinary approach. The low incidence of head and neck cancer in the Netherlands and the complexity of the treatment of these tumours were the reason to concentrate the care for these patients in multi disciplinary head and neck cancer centres.

Cancer Care Facilities↗
PubMed1999

A comparison of results after radiotherapy and surgery for stage I squamous cell carcinoma of the lower lip.

BACKGROUND: Controversy still exists as to whether radiotherapy or surgery is the preferable therapeutic modality for stage I squamous cell carcinoma of the lower lip. Therefore, a retrospective study was undertaken to compare the results of both treatment modalities. METHODS: The results of 90 patients who received radiotherapy and 166 patients who underwent surgery as the primary form of treatment for their stage I primary squamous cell carcinoma of the lower lip were evaluated. Tumor size and histological grade of differentiation were assessed. RESULTS: Local control rates were the same with radiotherapy or surgery. Overall survival rates for both groups of patients were similar as well. Disease-free survival rates in the patients who underwent radiotherapy were significantly lower compared with the surgically treated group. This was due to a higher occurrence of regional metastases in the patients who received radiotherapy. Univariate analysis showed that irradiated patients had a statistically significant greater tumor size. The difference of histological differentiation between the groups was also statistically significant, the poorly differentiated being more common in the irradiated group. Multivariate analysis showed that only tumor size carried significant independent prognostic information. CONCLUSIONS: The cure rates of stage I squamous cell carcinoma of the lower lip are favorable whether treated by radiotherapy or surgery, and local control rates are similar. The radiotherapeutic treated group showed an increased incidence of cervical metastases, which was due to the more advanced tumor size in these patients.

Adult↗
PubMed1999

Relationship of tumor thickness in punch biopsy and subsequent surgical specimens in stage I squamous cell carcinoma of the lower lip.

OBJECTIVE: Among the histologic features of squamous cell carcinoma of the lower lip, maximum tumor thickness in particular is a predictor of regional nodal metastatic spread and thus an important parameter in treatment planning. The purpose of this study was to investigate the relationship between maximum tumor thickness in punch biopsies and maximum tumor thickness in subsequent surgical specimens. STUDY DESIGN: This retrospective study examined the relationship between maximum tumor thickness in punch biopsies with that in subsequent surgical specimens obtained in 72 patients with clinical stage I squamous cell carcinoma of the lower lip. RESULTS: A correlation between maximum tumor thickness in punch biopies and in subsequent surgical specimens was found only for tumors with a thickness less than 3 mm. CONCLUSIONS: Reliable predictive information could be obtained from punch biopsies with a maximum tumor thickness less than 3 mm. When the maximum tumor thickness exceeds 3 mm, better information may be obtained from either a large incisional biopsy or the surgical specimen.

Adult↗
PubMed1999

Risk of second primary cancer following treatment of squamous cell carcinoma of the lower lip.

The risk of second primary cancers (excluding skin cancers) was evaluated among 56 patients who underwent treatment for a squamous cell carcinoma of the lower lip. The mean follow-up was 5.5 years. Ten patients (17.8%) developed at least one new primary cancer. The prevalence of second primary cancers within the respiratory and upper digestive tract, and elsewhere in the body, was 19.4 and 12.9 per 1000 person-years of follow-up, respectively. Patients were at risk for a second primary cancer at a steady rate of 2.7% per year during at least 5 years.

Adult↗
PubMed1999

Closure of radial forearm free flap donor site with local full-thickness skin graft.

A triangular shaped full-thickness skin graft harvested adjacent to the donor site of the radial forearm flap, as originally described by Liang et al, has successfully been used in seven consecutive patients for coverage of the donor site of the radial forearm free flap. In all patients this resulted in a robust coverage with no late wound breakdown and an aesthetic appearance far superior to split-thickness skin-graft coverage. We recommend this technique which is feasible in the majority of cases and reduces both donor site and graft site morbidity of the radial forearm flap.

Bandages↗
PubMed1998

Surgical treatment of squamous cell carcinoma of the lower lip: evaluation of long-term results and prognostic factors--a retrospective analysis of 184 patients.

PURPOSE: A retrospective study was undertaken to evaluate the results of surgical treatment of primary squamous cell carcinoma of the vermilion border of the lower lip and to identify parameters of the primary tumor that may predict local recurrence and regional metastasis. PATIENTS AND METHODS: From 1979 through 1992, 184 consecutive patients with a primary squamous cell carcinoma of the lower lip underwent surgical excision as a primary treatment. There were 166 (90.2%) men and 18 (9.8%) women, with a mean age of 66 years. Most cases (92.9%) were stage I tumors. Most of the tumors were well and moderately differentiated squamous cell carcinomas (93.5%). Minimal follow-up was 2 years, with a mean of 56 months. Disease control was achieved in 165 (89.7%) patients. Local recurrence and regional metastasis occurred in 9 (4.9%) and 10 (5.4%) patients, respectively. Local failures were treated successfully by either surgery or radiation therapy. Regional metastases were treated in nine patients by neck dissection, followed in eight cases by radiation therapy. One patient developed distant metastasis. RESULTS: Five- and 10-year overall survival rates were 78% and 61%, respectively, whereas the disease-free survival rates at 5 and 10 years were 86% and 81%, respectively. Multivariate analysis indicated that local recurrence was significantly associated with large tumor size and surgical margins containing squamous cell carcinoma. Increasing tumor thickness, an infiltrative invasion pattern, and perineural invasion were significant prognostic indicators of regional metastasis. CONCLUSION: Surgical treatment for small squamous cell carcinomas of the lower lip has a favorable prognosis. Particular parameters of the primary tumor seem to predict the chance of development of local recurrence and regional lymph node metastasis.

Adult↗
PubMed1998

Etiology of cancer of the lip. A review.

A range of environmental and host factors has been identified to explain the etiopathogenesis of squamous cell carcinoma of the lip. However, the definitive pathogenic pathway remains unclear. Carcinogenesis does not seem to be limited to a single agent, but rather to a complex multistep process of interactions between putative risk factors. In this paper, the currently available data regarding risk factors, considered to be causally related to the onset of lip cancer, are reviewed.

Black People↗
PubMed1998

Epidemiology of cancer of the lip in The Netherlands.

Descriptive epidemiological data of new cases of squamous cell carcinoma of the vermilion border of the lip in the Netherlands from 1989-94 inclusive are presented. Lip cancer represented 0.47 and 0.09% of all new malignancies in males and females, respectively. The lower lip was the most frequently affected site. The majority of the lip cancers were diagnosed in tumour stage I. The median age at diagnosis in males was 68 years, 5 years less than in females. The overall male-to-female ratio was 5.7. Age-adjusted incidence rates in males and females were 2.2 and 0.3 per 100,000 (ESR), respectively. The cumulative lifetime risk for developing lip cancer was 0.15 for males and 0.03 for females. Mortality/incidence ratios in males and females were 0.05 and 0.07, respectively. Differences in lip cancer incidence were observed between an urban and a rural area. There was a positive association between the occurrence of lip cancer and rural residence; rate ratios were 3.3 among males and 3.5 among females.

Adolescent↗
PubMed1998

[A numb chin and bottom lip: a closer look at the symptoms].

The numb chin syndrome, not due to trauma, dental pathology, preprosthetic surgery or orthognatic surgery, is an uncommon pathological condition. In patients with a numb chin a malignant disease or a metastasis of an (un)known malignancy has to be considered.

Chin↗
PubMed1997

Squamous cell carcinoma of the lower lip in renal-transplant recipients. Report of six cases.

The incidence of squamous cell carcinoma of the lower lip in immunosuppressed renal-transplant recipients is considerably higher than in the normal population. In addition to immunosuppressive treatment, the most important risk factors for the development of lip cancer in these patients are exposure to sunlight and smoking habits. Regular surveillance of renal-transplant recipients and early biopsy of premalignant lesions of the lip allow early detection of lip cancer. Patients should also be advised to avoid unprotected exposure to sunlight, to use appropriate sunscreens and to stop smoking. Six cases of squamous cell carcinoma of the lower lip in renal-transplant recipients are described.

Adult↗
PubMed1996

Results of radiotherapy for squamous cell carcinoma of the vermilion border of the lower lip. A retrospective analysis of 108 patients.

The authors analyzed the clinical history, tumor histology and stage, and outcome of a group of 108 patients with squamous cell carcinoma (SCC) of the vermilion border of the lower lip who underwent radiation therapy in the period between 1980 and 1992. The median follow-up was 77 months. The disease stages were T1 in 89 (82.4%), T2 in 17 (15.7%), and T3 in 2 cases (1.9%). At presentation, regional lymph nodes were clinically negative in all but 3 patients. The total tumor dose varied from 48 Gy to 70 Gy, depending on the radiation modality (orthovoltage, electrons, photontherapy and iridium implants). Local control was achieved in 88 out of 89 (98.9%) patients with T1, in 13 out of 17 (76.5%) patients with T2 and in both patients with T3 tumors. Local treatment failures (4.6%) were cured by salvage surgery. During follow-up, regional lymph node metastases at level I (submental and submandibular groups) occurred in 11 out of 89 (12.4%) patients with stage I and in I out of 15 (6.7%) patients with stage II tumors. All these patients underwent therapeutic neck dissection, followed by radiotherapy in 8 cases. Two patients developed distant metastases. Thus, after salvage treatment of local failures and regional metastases the total group of patients with stage I and II SCCs of the vermilion border of the lower lip showed a definitive control rate of 98.1%.

Adult↗
PubMed1996

Oncologic aspects of vermilionectomy in microinvasive squamous cell carcinoma of the lower lip.

Twelve patients with microinvasive squamous cell carcinoma of the lower lip were studied in order to determine whether vermilionectomy was justifiable. The maximum tumor thickness (MTT) varied between 1.1 and 3.1 mm. In none of the patients was there local recurrence during a mean follow-up period of 4.4 years (range 4-8). In view of these results and of what has been reported in the literature, it seems warranted to conclude that vermilionectomy is an appropriate procedure in microinvasive carcinoma of the lower lip with a MTT of up to 3 mm.

Aged↗
PubMed1996

Giant keratoacanthoma of the lower lip. Report of a case of spontaneous regression.

The case of a 46-year-old man who refused treatment of a giant keratoacanthoma of the lower lip is presented. Complete regression took place within 10 months. The dilemma of a lesion of the vermilion border of the lower lip being either a (giant) keratoacanthoma or a squamous cell carcinoma is discussed with respect to the management of such lesions.

Biopsy↗