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Biomedical subjects

J Göthlin

Publications and source records attributed to J Göthlin.

At least 19 recordsLinked to original sources
PubMed1987

The effects of clinical data on radiological diagnostic performance in middle-face trauma.

To determine the effect of clinical information on the radiological diagnostic performance in middle-face injury, the medical records and radiographs of 618 patients with middle-face injury were reviewed. The information value of clinical data given in each x-ray requisition was evaluated. The radiological diagnoses were compared with the final clinical diagnoses both retrospectively and prospectively (with and without clinical data). Knowledge of clinical data with statistical significance changed the reader's decision threshold towards improved sensitivity but poorer specificity. Clinical data did not improve the radiologists' performance. Clinical data may be helpful in diagnostic tasks rather by increasing the sensitivity than the specificity.

Evaluation Studies as Topic↗
PubMed1986

Computed tomographic arteriography (CTA) of the liver. Evaluation of technique, results and indications.

Computerized tomographic liver angiography was performed in 57 patients, of which 47 had metastatic disease. The goals of the investigation were to preoperatively 1. determine number, extent and nature of liver lesions, 2. define the hepatic vasculature. Early CTA could in 14 of the patients correctly direct further clinical management. CTA is a good examination modality for selecting candidates for liver surgery for neoplastic disease.

Angiography↗
PubMed1985

Screening for hematuria, glucosuria and proteinuria in people aged 55-64. Technical, clinical and cost-benefit experience from a pilot study.

A total of 754 persons randomly selected from the age group 55-64 years were invited by letter to take part in a screening for hematuria, proteinuria and glucosuria. Each person was asked to provide one sample of morning urine and immediately mail it to the laboratory. A total of 413 persons (55%) responded. Two dipsticks: BM-Test-5L and a new single strip for hematuria determination preliminary named BM 33075 were used, both manufactured by Boehringer Mannheim GmbH. The test strips gave positive reaction for hematuria in 21 persons (5.1%), for proteinuria in 14 persons (3.4%), and for glucosuria in six persons (1.5%). All persons with positive tests were invited to follow-up investigations. In the hematuria group we found one person with a malignant disease, 13 with benign conditions and in seven persons we found no reason for the hematuria. Among those with proteinuria one person had a nephritis. Four persons with glucosuria knew about their diabetes mellitus. The cost of the screening was NOK 99 per participant.

Cost-Benefit Analysis↗
PubMed1983

Comparison of the visibility of the anatomical structures of the facial skeleton in panoramic zonography and linear tomography.

The value of cylindrical panoramic radiography (using one rotational axis), a modification of orthopantomography (using three rotational axes), in radiographic examination of maxillo-facial skeleton was estimated by evaluating the visualization of anatomical structures of the facial skeleton on cylindrical panoramic and linear tomographic radiographs of 51 patients examined with both methods. The radiographs were independently reviewed by four radiologists. The visualization of the lateral wall of the orbit and maxillary sinus, nasal septum, alveolar process and zygomatic corpus was better on cylindrical panoramic radiographs. Linear tomography visualized the media wall of orbit better. In visualizing the frontal sinus, orbital floor, medial wall of maxillary sinus and hard palate there were no significant differences between linear tomography and panoramic zonography.

Adolescent↗
PubMed1983

Radiation doses during panoramic zonography, linear tomography and plain film radiography of maxillo-facial skeleton. A comparative study.

The radiation doses to the organs and the skin of the head and neck during plain film radiography, a-p and p-a linear tomography and panoramic zonography of the maxillo-facial skeleton were measured on a sliced anatomic Alderson skull phantom with LiF (TLD-100) thermoluminescence chips. The doses were clearly highest during the linear tomography. Also the doses during the plain film radiography were quite high. Compared to the conventional methods the doses from the panoramic Zonography were minimal.

Cervical Vertebrae↗
PubMed1983

The effect of ethacrynic acid on biliary excretion, concentration of ioglycamide and bile flow in dogs.

The effect of ethacrynic acid (EA), an agent which increases bile acid independent bile flow, on the biliary excretion and concentration intravenously administered biliary contrast agent ioglycamide was studied on cholecystectomized anesthetized dogs equipped with Thomas cannula through which the common bile duct could be cannulated. One hour after cannulation i.v. infusion of ioglycamide at a rate of 4 mu mol./min./kg. was started. Two hours later 1 mg./kg. of ethacrynic acid was injected intravenously. This procedure was repeated three times on four dogs, five dogs receiving comparable volume of saline at comparable time serving as controls. Bile was collected at 15 min. intervals and simultaneous i.v. blood samples were taken. EA injection caused decrease in biliary ioglycamide concentration and biliary excretion of ioglycamide and a slight but statistically not significant decrease in bile flow. Since EA is an organic anion and the increase in bile flow induced by it has been shown to be related to the biliary excretion of its metabolites, it may be suggested that EA as an organic anion inhibited biliary excretion and hepatic uptake of ioglycamide but having lower choleretic effect its excretion could not increase the bile flow.

Animals↗
PubMed1983

The effect of taurocholate on canine bile flow, biliary excretion and concentration of ioglycamide.

The bile acid taurocholate increases the biliary excretion of organic anions, such as sulfobromophthalein (BSP), bilirubin and iopanoic acid. In the present study has been investigated the effect of taurocholate on 1. Canine biliary excretion and concentration of the i.v. contrast medium ioglycamide and 2. Canine bile flow. The experimental model consisted of cholecystectomized, anaesthetized dogs with a fistula, through which the common bile duct could be catheterized and drained. One hour after cannulation, i.v. infusion of ioglycamide at a rate of 4 mumol/min./kg. was started. Two hours after the infusion start a control group received i.v. infusion of saline, while in another a 1.5% sodium taurocholate infusion was started with stepwise increases with 30 min. intervals from 0.4 to 0.8, 1.6 and 3.2 mumol/min./kg. Compared with control, all rates of taurocholate infusion increased bile flow and decreased biliary ioglycamide concentration. Although the bile flow with increasing taurocholate infusion rates was enhanced, the biliary ioglycamide excretion did not increase. The results indicate that ioglycamide and taurocholate are excreted into bile by separate excretion mechanisms. As taurocholate increases the biliary excretion of some other organic anions, it supports the hypothesis that organic anions are excreted into bile by more than two excretion mechanisms, taurocholate affecting only some of them.

Animals↗
PubMed1981

Effects of vasopressin, noradrenalin and oxytocin on blood flow distribution in rat kidney with neoplasm.

The arterial blood flow distribution between tumour and intact renal tissue was investigated in rats with transplanted sarcomas. Changes in tissue flow were measured by the microsphere tracer technique, and the redistributing effects on blood flow of vasopressin, noradrenalin and oxytocin was recorded. Bolus injections of vasopressin gave a transient decrease of intact tissue flow, not found in tumours. At increasing doses of vasopressin and in early tumour growth phase, the flow discriminating effect tended to vanish. Constant intravenous infusion of vasopressin gave similar reduction of flow in tumour and intact tissue. Selective administration into the renal artery reduced flow in intact tissue but produced ambiguous effects in tumour tissue. Noradrenalin produced less reduction of tumour flow as compared with intact tissue flow. Oxytocin increased tumour blood flow while no flow change occurred in intact tissue. Oxytocin thus appeared to produce the most favourable redistribution of flow within tumour kidneys for the prospect of conveying cytotoxic agents selectively to the tumour.

Animals↗
PubMed1980

Proteinuria after selective nephroangiography in man. Comparison of three contrast media.

The proteinuria following aortography and selective nephroangiography in 60 patients using Isopaque Cerebral, Urografin 60% and Amipaque was investigated. The results indicate an increase in glomerular permeability and possibly an overload of tubular reabsorptive capacity after angiography. The changes are transient. No permanent injury to the kidney appears to occur.

Albuminuria↗