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Biomedical subjects

J Göthlin

Publications and source records attributed to J Göthlin.

At least 55 records · Page 3Linked to original sources
PubMed1976

Blood flow determination in splenorenal shunts using a dye dilution technique.

Determination of flow through splenorenal shunts performed for portal hypertension was tried in 7 patients using a dye dilution technique. Varying shunt flows were obtained. The results of the flow determinations were compared with the findings at arteriography and the cause of the varying flows could be revealed. Retrograde flow through the left ovarian vein leading to incomplete mixing was the most common source of error. The employed dye dilution techniques lends itself to shunt flow determination only if sources of error can be ruled out by arteriography.

Dye Dilution Technique↗
PubMed1976

Renal artery injuries following blunt trauma.

From 1861 to 1975 fifty-three cases of blunt renal pedicle injury have been reported. Sixty-five kidneys were involved (twelve bilateral injuries) and 32 of them were removed. Reconstructive surgery was tried on 17 kidneys, of which only one healed without complication and with recovery of normal function. In addition, in 4 patients with bilateral injury, operation preserved enough kidney function to save the patients from hemodialysis, though 2 of them developed hypertension. This paper reports 4 further cases. In 2 patients with renal artery thrombosis nephrectomy was eventually performed after preceding reconstructive or conservative treatment. The third patient with thrombosis was not seen until several years after the trauma and was treated conservatively. The fourth patient had a ruptured intrarenal arterial branch with massive hematuria and finally required resection of the kidney. An early diagnosis of renal artery injury following severe abdominal trauma requires immediate aortography, sometimes with subsequent selective catheterization. If renal trauma is not strongly suspected, intravenous large dose pyelography may be indicated as the first step. Surgical repair should consist of resection of the injured artery and reconstruction with a venous graft, or autotransplantation of the kidney. If treated conservatively, the patient must be followed up at regular intervals for hypertension and other complications.

Abdominal Injuries↗
PubMed1975

Absorption of digoxin in man after oral and intrasigmoid administration studied by portal vein catheterization.

The absorption of digoxin has been studied in fasting patients undergoing transumbilical, portal catheterization for diagnostic purposes. A purely aqueous solution was administered orally in 4 patients and in the sigmoid colon in 2 patients. Blood samples were taken simultaneously from the portal and a peripheral vein. Plasma digoxin concentrations were determined by radioimmunoassay. Digoxin appeared early in the blood after oral administration; the average peak of porto-peripheral concentration differences was at 18 min. After intrasigmoid administration, absorption was slower, and no distinct peaks were found. Calculation of the mean amounts absorbed showed that half the dose had been absorbed via the portal vein during 2 hours in the oral study and during6 hours in the intrasigmoid test. Approximately 2/3 of the dose had been absorbed during 6 hours after oral dosing. The absorption rate was estimated taking into account the decreasing amount of drug left to be absorbed at different times. After cral administration, the mean peak rate was found to correspond to an absorption half-time of 0.78 h, which was more than 20 times faster than the rate after 6 h. The mean rate after intrasigmoid administration appeared to be about 1/3 of that after oral dosing. Physiological factors that might account for these differences in absorption rate are discussed.

Administration, Oral↗
PubMed1975

Effects of vasopressin in experimental nephroangiography.

Nephroangiography was performed in 13 rabbits using eight-fold magnification with a 0.05 mm focus. After arginine vasopressin in doses of 0.01 to 1.0 IU the glomeruli were well demonstrated as well as the subcortial arteries and veins and the concentration of contrast medium in arteries and veins increased. At increasing doses of vasopressin the glomeruli were shut off to an increasing degree, beginning at the outer part of the cortex. At 1.0 IU only the juxtamedullary glomeruli functioned.

Animals↗
PubMed1975

Superior mesenteric angiography and blood flow following intra-arterial injection of prostaglandin F2alpha.

The effect of intra-arterially administered prostaglandin F2alpha(PGF2alpha) on venous demonstration in angiography of the superior mesenteric artery was compared to that of bradykinin in 10 patients, and the flow increase in this vessel following PGF2alpha was measured by a dye dilution technique in another 8 patients. The angiographic demonstration of veins was similarly improved by the 2 drugs, the effect of 60 mug. of PGF2alpha being roughly equivalent to that of 10 mug. of bradykinin. The loss of arterial detail was less marked after PGF2alpha which, however, had a longer duration of action. The flow studies indicated that 80 mug. of PGF2alpha increased the superior mesenteric blood flow 103 +/- 16 per cent. There was no influecne on blood pressure or pulse rate. The patients experienced a sensation of warmth in the abdomen for a few seconds following the injection of drugs, but no other side effect was noted. It is concluded that PGF2alpha causes a rapid increase of the superior mesenteric blood flow in man making it suitable for pharmacoangiography of this vascular bed.

Adult↗
PubMed1975

Angiography in expansile lesions of the spleen.

The angiographic findings in a relatively large number of expansile lesions of the spleen are presented. In cysts our findings correspond to those in earlier reports, the hallmark being stretching of intrasplenic arteries and veins around an avascular espansile lesion. As to neoplasms (primary as well as secondary), however, our findings suggest that the criteria of malignancy, that is, neovascularity, vascular encasement, and arteriovenous shunting, may be more frequent than is evident from earlier reports.

Adolescent↗
PubMed1975

Technique and complications of transumbilical catheterization of the portal vein and its tributaries.

In 120 patients who had 127 transumbilical catheterizations of the portal vein, 33 of pancreatic veins, and 15 for other portal tributaries, the surgical success rate was 91 per cent over-all, increasing to 95 per cent during the last year. Catheterization was made with the same technique as is used for arteriography. The most important complication was thrombosis of the portal vein, giving slight transient symptoms in 2 patients. Other complications were wound infection, suture granuloma, herniation in the linea alba, bleeding from the operative wound, and subintimal injections. As the technique may yield good results in studies of drug resorption, flow studies, detection of metastases, and investigation of pancreatic veins, it seems justified in suitable patients despite the complication rate. None of the complications produced lasting disability.

Adolescent↗
PubMed1975

Renal hemangiomas. An analysis of 13 cases diagnosed by angiography.

The angiographic findings in 13 patients with renal hemangiomas (one pararenal) are presented. The material suggests, contrary to earlier reports, a predominance for the female sex and the right kidney. Nine of the patients had macroscopic hematuria, of which five had renal colic. Obstruction was found at urography in seven cases. Renal angiography is the definitive diagnostic procedure and should be performed in all cases of unexplained macroscopic hematuria. Diagnosis may eventually be improved by pharmacoangiography or by hemodynamic studies using a dye dilution technique, as small arteriovenous shunts may remain undetected at angiography. Cardiac decompensation was not noted in our material, even though arteriovenous shunting within the hemangioma was seen in eight cases, suggesting that the shunt flow in renal hemangiomas usually does not reach levels high enough to impair the general circulation. Hypertension was present in only one patient, attributed to chronic pyelonephritis. Hematuria disappeared in all nine patients operated upon.

Adult↗