PubMed Health⌕ Search

Biomedical subjects

J Gage

Publications and source records attributed to J Gage.

26 records · Page 2Linked to original sources
PubMed1979

Prevention of stromal ulceration in the alkali-burned rabbit cornea by glued-on contact lens. Evidence for the role of polymorphonuclear leukocytes in collagen degradation.

Stromal ulceration of the alkali-burned rabbit cornea was found to be associated invariably with phagocytically active polymorphonuclear leukocytes (PMNs). A glued-on methylmethacrylate lens applied to corneas soon after burning, however, prevented re-epithelialization and also prevented PMN infiltration of the stroma and stromal ulceration. Subsequent partial detachment or complete removal of the lens resulted in epithelial resurfacing of the stroma, PMN infiltration, and stromal ulceration. Glued-on lenses applied to already ulcerating corneas arrested further ulceration by prohibiting additional PMN infiltration. Either surface debridement or glued-on methylmethacrylate rings also prevented re-epithelialization and ulceration in stromas not infiltrated by PMNs, but neither treatment was sufficient to prevent ulceration in corneas already containing numerous PMNs. The data suggest the possibility that the epithelium stimulates infiltration of the stroma by PMNs which then participate in stromal matrix degradation. Although no claim is made that only PMNs mediate matrix destruction in corneal ulceration, the efficacy of the lens would seem to be due to exclusion of the epithelium and the consequent prevention of stromal infiltration by PMNs.

Alkalies↗
PubMed1978

Effect of topical corticosteroids on ulceration in alkali-burned corneas.

Dexamethasone sodium phosphate was administered topically to one eye of rabbits with bilateral alkali corneal burns, and saline solution was administered to the contralateral eye. Topical steroids were also administered in animals with moderate corneal ulcers and were found to enhance the severity of ulceration when given during the second and third weeks following the burn. If the corticosteroids were given daily in the first six days or in the fourth and fifth weeks following the burn, they did not have an adverse effect on the cornea. Corticosteroids can be used intensively during the first week following an alkali burn, without increasing the risk of corneal melting. The mechanism for the enhancement of corneal ulceration is not a direct augmentation of collagenase activity, but probably involves the inhibition of repair processes.

Alkalies↗
PubMed1975

Distribution and metabolism of 2,4,5,2', 5'-pentachlorobiphenyl.

Single doses of 2,4,5,2',5-pentachlorobiphenyl uniformly labeled with 14-C have been administered intravenously and orally to mice. Whole-body autoradiograms and scintillation counting of tissue samples have shown that most radioactivity leaves the circulation for the tissues within one hour. Peak concentrations varied, being highest in brown fat, which after 24 hours comprised the major reservoir of the unchanged compound in the body. Radioactivity disappeared rather rapidly drom most other tissues, although the longest retention occurred in bronchial epithelium and some parts of the renal tubules. The excretion of radioactivity was mainly through the bile, into feces, with a half-time of six days. There was little unchanged compound in the feces, the major metabolite was a hydroxylated derivative, both free and conjugated.

Adipose Tissue, Brown↗
PubMedDate not supplied

The psychiatric consultation/liaison nurse role in case management.

Psychiatric consultation/liaison nurses focus on the emotional, spiritual, developmental, cognitive, and behavioral responses of patients and families. They help patients, family, staff, and the entire healthcare system cope with a medical illness and its treatment. Use of psychiatric consultation/liaison nurses ensures that the patient's emotional needs are met, patients and families feel more cared for and respected, and patient satisfaction is increased. Partnerships between case managers and psychiatric consultation/liaison nurses may be especially effective with complex cases, end-of-life decisions, unanticipated hospital stays, certain pediatric populations, and patients who are hospitalized far from home. This article includes four case studies to illustrate such partnerships in a large teaching hospital.

Adaptation, Psychological↗