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J Gajewski

Publications and source records attributed to J Gajewski.

106 records · Page 6Linked to original sources
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Unrelated donor bone marrow transplants in children.

Only a small proportion of children who might benefit from bone marrow transplant (BMT) have an HLA-identical sibling. To provide this potentially curative therapy to patients without a matched related donor, marrow transplants using less well matched related donors or unrelated donors (identified through computerized donor registries) have been performed. We report the outcome of 24 consecutive unrelated donor BMT's performed on children. Eligible diagnosis included acute leukemia (AL) (n = 15), chronic myelogenous leukemia (CML) (n = 4), myelodysplastic syndrome (MDS) (n = 3), and severe aplastic anemia (SAA) (n = 2). All donor/recipient pairs were sero-matched at 5 or 6 of the 6 HLA A, B, and DR antigens. Several different preparative regimens were used, but fractionated total body irradiation (TBI) was used in 20 patients. All recipients received graft-versus-host-disease (GVHD) prophylaxis with cyclosporine-A (CSA), four with short course methotrexate (MTX), 14 in combination with short course MTX and methylprednisolone (MPS), and five in combination with a mouse monoclonal antibody to CD5, coupled to the A-chain of ricin (Xomazyme-65). One patient received CSA and MPS alone after a T-cell depleted marrow transplant. Twenty of 23 evaluable recipients engrafted (87%). Two patients with CML never engrafted and had autologous marrow recovery, one patient with SAA died at 128 days without evidence of engraftment, and there was one early death at day + 9. Fourteen of 20 patients (70%) with stable donor-derived hematopoiesis developed significant acute GVHD > or = grade II). Eleven of 15 engrafted patients who survived > 100 days after BMT developed chronic GVHD (73%).(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Forearm tremor during three different isometric loadings.

Forearm tremor was studied during a spring (stiffness 1090 N.m-1), a rigid isometric and a "dynamic" isometric (carrying a freely hanging mass) loading at the level of 50% of maximal isometric voluntary contraction. Thirteen physical education students ranging in age between 20 and 28 years flexed their dominant forearm isometrically towards the vertical direction (90 degree elbow angle) against the three different loads on three test occasions seated on a dynamometer which measured the force at the wrist together with vertical tremor (accelerometer). A power spectrum density function was established for the tremor (acceleration) between 1.0 and 19.9 Hz. A bandwidth of 6.9-19.9 Hz was subsequently analyzed in more detail including the determination of peak power (PMAX), peak power frequency (FMAX), mean power frequency (MPF), and average power (PAVER) as well as proposition (%) of the whole spectrum occupied by the selected bandwidth. The FMAX, MPF and band percentage variables had the best reproducibility (Cronbach's Alpha 0.85-0.95), while for the PMAX and PAVER the coefficients were lower but still satisfactory (0.69-0.89). The coefficients were rather similar for all three loading conditions. In the spring loading the spectrum components inside the analyzed frequency band occupied almost 90% of the whole spectrum, FMAX was more clearly distinguished from the rest of the spectrum, and tremor amplitude was higher and tremor frequency lower than in the rigid isometric and "dynamic" loadings. The respective tremor amplitude and frequency characteristics showed statistically significant correlations between the rigid isometric and "dynamic" loading conditions.(ABSTRACT TRUNCATED AT 250 WORDS)

Acceleration↗