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Biomedical subjects

J Gallwey

Publications and source records attributed to J Gallwey.

4 recordsLinked to original sources
PubMed1992

The psychosocial impact of HIV infection in gay men. A controlled investigation and factors associated with psychiatric morbidity.

This study aimed to establish the prevalence of psychosocial problems in gay men with HIV infection, and to identify factors associated with psychological morbidity. The study was a cross-sectional controlled investigation, which included 24 HIV seropositive and 25 seronegative gay men. Outcome measures included current psychological status and psychiatric history; coping and health beliefs; and social and sexual functioning. Seropositive subjects had worse scores on the PSE total score, and greater sexual difficulties. There were also differences in health beliefs and coping. Psychological morbidity was associated with hopelessness, previous psychiatric illness, symptomatic HIV disease, and low self-esteem.

Adaptation, Psychological↗
PubMed1988

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides.

Current candidate vaccines fail to protect primates against challenge with human immunodeficiency virus (HIV) in the presence of antibody responses; this underlines the importance of studying cell-mediated immunity to HIV and identifying specific epitopes that stimulate cytotoxic T lymphocytes (CTL). Using a recombinant vaccinia virus to express the gag protein of HIV-1 we found HLA class-I-restricted gag-specific CTL in thirteen out of fifteen healthy HIV seropositive patients. We then used short synthetic peptides in the lysis assay to screen for gag CTL epitopes. In one patient we have identified a peptide in p24 that is recognized by CTL in association with HLA-B27. This peptide, and further peptide sequences defined by these methods, could be incorporated in vaccines designed to induce cell-mediated immunity against HIV.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Alcohol misuse in patients attending a genitourinary clinic.

Two hundred male and 200 female attenders at a genitourinary clinic were studied to determine the prevalence of alcohol misuse. The CAGE Questionnaire was used to estimate the presence of probable alcohol misuse, and the General Health Questionnaire (GHQ) was used to assess psychiatric morbidity. Over 18% of men and over 12% of women were found to be alcohol misusers as measured by the CAGE Questionnaire. Their characteristics are reported, and the implications of the findings considered.

Adolescent↗