Biomedical subjects

J Galobardes

Publications and source records attributed to J Galobardes.

3 recordsLinked to original sources

PubMed1994

Thymolipoma: analysis of 27 cases.

PURPOSE: To characterize the radiologic features of thymolipoma. MATERIALS AND METHODS: Twenty-seven cases of thymolipoma were reviewed. Clinical, radiologic, and pathologic findings were noted. RESULTS: The masses occurred in 15 male and 12 female patients (mean age, 26.7 years). All 27 tumors were in the anterior mediastinum; 22 were in the anterior inferior mediastinum. On frontal radiographs, 12 tumors simulated cardiomegaly. On lateral radiographs, 12 tumors draped over the ipsilateral hemidiaphragm, simulating diaphragmatic elevation. Computed tomographic scans (n = 11) demonstrated a mixture of fat and soft-tissue attenuation in 10 tumors corresponding to adipose and thymic elements found at microscopy. Magnetic resonance images (n = 2) demonstrated fat and soft-tissue signal intensity characteristics. Both types of studies showed a connection between tumor and thymus. CONCLUSION: Thymolipomas are anterior mediastinal masses that may conform to the shape of adjacent structures. The diagnosis is supported by imaging studies that demonstrate fat and soft tissue within the tumor.

Adipose Tissue↗

PubMed1992

Thymoma: radiologic-pathologic correlation.

Thymoma is the most common primary neoplasm of the thymus. The majority of thymomas are encapsulated masses and exhibit a benign behavior. Less frequently, thymomas may be locally invasive, or rarely they may metastasize to distant sites. The usual clinical presentation is that of an anterior mediastinal mass found incidentally in an asymptomatic patient. The variable gross features of thymoma and the potential for local invasion result in a variety of radiologic appearances. The most common radiologic manifestation is a rounded, soft-tissue mass of the anterior superior mediastinum. Computed tomography and magnetic resonance imaging typically show a prevascular mediastinal mass of variable size and may be helpful in the evaluation of adjacent structures in cases of invasive thymoma. The treatment of choice is complete surgical excision. Radiation therapy and chemotherapy may be used adjunctively to surgery in the treatment of invasive tumors. The prognosis of encapsulated thymoma is generally favorable. Invasive tumors are associated with a worse prognosis but may respond to radical resection.

Adult↗

PubMed1976

The evaluation of a radio gas-chromatographic system for the detection of trace amounts of labelled insecticides.

A radio gas-chromatographic system consisting of a gas chromatograph, combustion furnace, proportional counter and guard scintillation counter has been studied for the analysis of trace amounts of 14C-labelled organophosphorus insecticides. The proportional detector is a concentration sensitive detector requiring strict flow control. Sensitivity depends on the concentration of the quenching gas used. Using 14C-ethyl parathion and 14C-metamidophos as model compounds a linear range of 3500-5000 was measured. A sensitivity of 0.98 cpm/pCi and a detection limit of 24pCi were obtained which allows the detection of 0.33 ng if the specific activity of the insecticide is 21.5 mCi/mMol. The system must be decontaminated in order to achieve optimum detection levels by passage of oxygen through the combustion tube and by periodically injecting the corresponding non-labelled compound into the column. A solvent effect was found to interfere in the analysis due to the sudden production and expansion of CO2. This effect was eliminated by choosing column conditions to prevent elution near the solvent. The system was tested by analyzing a mixture of 37 ppb and 23 ppb of ethyl parathion and its oxygen analog in orange juice.

Chemical Phenomena↗