Biomedical subjects
Publications and source records attributed to J Gayer.
The authors describe a case of pulmonary haemorrhage in a neonate associated with adnatal pneumonia and infection with Staphylococcus epidermidis. The authors discuss the problem of this serious complication of the neonatal period as well as the limited diagnostic and therapeutic possibilities.
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Regular examinations of thyroid function in newborn infants were started in the district of Praha 10 in 1975. Later the incidence of congenital hypothyroidism in Czechoslovakia was assessed in a pilot study including several centers in 1981. As a screening method we used the estimation of total thyroxine (T4) in a dried spot of blood obtained from a heel prick on the fifth day after birth. A total of 45,535 newborns was screened by such method and the incidence was 1:5059 of live born infants. Since 1985 the screening of congenital hypothyroidism has been extended to cover the whole territory of Czechoslovakia. Three screening centers (in Praha, Brno and Banská Bystrica) are responsible for carrying out this screening program. The first screening method employed was the determination of total thyroxine in a dried spot of blood on filter paper as mentioned above. By the end of December 1987, 313,618 samples from newborns have been assayed in Bohemia and Moravia. The incidence of congenital hypothyroidism was found to be 1:5700 of live newborn infants. The treatment of detected cases was started before the end of the first month after birth which ensured normal development of children thus afflicted. When T4 was the first method employed, a relatively high incidence of altered TBG (thyroxine binding globulin) production (1:6400) was encountered, especially in boys.
Two to twelve hours after suicidal ingestion of an estimated dose of 10 g chlorprothixene, a 31-year-old female was admitted to the emergency ward of the clinic with cardiorespiratory arrest. After successful resuscitation, the further clinical course was complicated by persistent ventricular extrasystoles and ventricular fibrillation which necessitated repeated defibrillation. Since the patient did not respond satisfactorily to supportive treatment, a combined hemoperfusion/hemodialysis was performed. Under extracorporeal detoxication, elimination of chlorprothixene from plasma was accompanied by substantial improvement of the patient's clinical condition, although only about 1.6% of the estimated dose had been removed. This case seems to indicate that evaluation of the therapeutic efficacy of hemoperfusion should not be based exclusively on the relation of the amount of the eliminated drug to total absorbed dose.
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Preparations of HEp-2 cell cultures seeded in concentrations of 120,000 per cm.2 and 15,000 per cm.2 and growing for 15 and 25 hours were studied with respect to local differences in the frequencies of monucleolar cells, seven types of which were distinguished by the values of nucleolar coefficient, multinuclear cells and mitotic cells in the neighbourhood of some cells. The latter exhibited the following features such as mononuclearity with NC ranging from 1 to 4, or mitosis. The observed differences are a) higher between the groups than between the levels of cells, b) higher in the distribution of cells than in the average nucleolar coefficient, c) most frequently in the neighbourhoods of mitotic and mononuclear cell with NC 4, and d) as a rule, complementarily dependent on the initial concentration of cells and the time of cultivation. The term "functional wholes" is proposed to describe those unique formations as well as the ones stated in the introductory remarks. The functional whole is a group of cells of the same type which are identical or closely similar in a variable feature.
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