PubMed Health⌕ Search

Biomedical subjects

J Geisert

Publications and source records attributed to J Geisert.

At least 55 records · Page 3Linked to original sources
PubMed1989

Beta-2-microglobulin in hemodiafiltered children: long-term efficiency follow-up.

Data of beta 2-microglobulin (beta 2M) levels are not well known in hemodialyzed children. We analyzed 28 children, all maintained on thrice weekly hemodiafiltration (HDF) with highly permeable membrane (mean age 8 years 7 months, mean time on dialysis 32 months). beta 2M is significantly elevated: 34 + 8.5 mg/l without differences for sex but correlated to residual urinary volume. The kinetics of beta 2M removal during HDF with different dialysis membranes (polysulfone, polyacrylonitrile), and with the same membrane (polysulfone) used in diffusive (hemodialysis), in convective (hemofiltration) and in diffusive and convective (HDF) modes reveals that polysulfone membranes in HDF mode allow the greatest beta 2M serum level drop over dialysis session time (-60 +/- 12%). Five children, anuric, mean time on dialysis 75 months (65-94), chronically on thrice weekly (3 x 3 h) HDF with first polyacrylonitrile then polysulfone membranes are investigated regarding beta 2M levels and amyloidosis risks. Despite the high removal rate of beta 2M with these dialytic modes, beta 2M serum levels do not decrease during this five-year study. High beta 2M serum extraction seems to be compensated by high beta 2M cell generation. Further investigation is necessary for the explanation of the presumed high beta 2M generation rate in the HDF with polysulfone membranes before recommendation of safe long-term use of such highly permeable membranes for prevention of amyloidosis risks in dialytic patients.

Adolescent↗
PubMed1988

[Renal transplantation in thrombosis of the inferior vena cava. Implantation of the graft vein in the portal vein].

An 8-year old girl with chronic renal failure underwent allogeneic renal transplantation with implantation of the renal vein of the graft on the portal vein, as the inferior vena cava was obstructed by thrombosis. The possible technical obstacles to renal transplantation are reviewed on that occasion, and solutions are suggested. In the presence of thrombosis of the inferior vena cava it seems necessary to determine its level and to look for a patent venous segment all the way up to the diaphragm. If no such segment is found, then the renal vein can be implanted on the portal vein.

Child↗
PubMed1988

Sequential hypertonic haemodialysis in children.

Sequential hypertonic dialysis (SHD) was studied in two binephrectomized children over a period of 6 weeks. Each dialysis session comprised four periods of 45 min. The concentration of sodium in the dialysate [Na(D)] during the first period was 190 mmol/l and during the second period 140 mmol/l. The sequence was then repeated. The sodium-free water clearance [C(ONa)] was calculated from the measurements of the ultrafiltrate clearance and of the sodium clearance. Despite the short periods of hypertonic dialysis, C(ONa) was positive, suggesting that water was removed from the intracellular compartment as well as from the extracellular fluid. The transfer of fluid from the intracellular space improved circulatory stability during rapid removal of large volumes of fluid by ultrafiltration. SHD was also associated with increased removal of potassium and phosphate. Comparison of clinical parameters before and during SHD showed a tendency towards increased sodium balance and the possibility of raised cardiovascular morbidity. SHD stabilized blood volume during ultrafiltration, encouraging removal of uraemic toxins. SHD with this level of Na(D) is only a study dialysis method.

Child↗
PubMed1988

Pharmacokinetics of teicoplanin in children.

A single dose of 6 mg/kg teicoplanin was infused over 10 min in six children of mean age 7 years, and a single dose of 6 mg/kg was infused over 20 min in four neonates of mean age 8.5 days. Serum sampling was performed at 0 and 10 min and at 1, 4, 12 and 24 h and thereafter 24-hourly, up to ten days. Urine was collected for each 24 h throughout the study in children. Teicoplanin was assayed by high performance liquid chromatography. Tolerability of teicoplanin was excellent both in children and in neonates. For all the patients the serum concentrations of teicoplanin followed an open two-compartment model. Mean Cmax was 48.6 +/- 16.7 mg/l (10 min) in children, and 19.6 +/- 1.05 mg/l (20 min) in neonates, and mean t1/2 beta was 20.5 +/- 5.5 h and 30.3 +/- 6.3 h, respectively. On the basis of the results dosage recommendations for children and neonates are made.

Adolescent↗
PubMed1988

[Urinary infections in children].

Urinary tract infection is frequent in childhood, usually without major consequences. Its diagnosis is often overestimated and needs precise bacteriological and cytological tests; systematic exploration of the urinary tract must be proposed if these tests are positive. The clinical presentation and the incidence of uropathies is strongly related to age. The therapeutic protocol will depend on germ, age, symptoms and results of morphological examinations.

Anti-Bacterial Agents↗
PubMed1988

[Severe theophylline poisoning in children. Value of hemodialysis with high permeability membrane].

The authors report a massive accidental ingestion of enteric-coated theophylline (Armophilline ) by a young child. A status epilepticus and elevated theophylline serum concentration (167 mg/l) led to use hemodialysis with high dialytic clearance. The elevated clearance was obtained by the use of high permeability membrane, by bicarbonate dialysate and the best quality of vascular access (Hickman catheter).

Child, Preschool↗
PubMed1987

Autosomal recessive and dominant forms of polycystic kidney disease are not allelic.

Linkage analysis has been carried out in 11 kindreds with autosomal recessive polycystic kidney disease (ARPKD) using the genetic marker 3'HVR, closely linked (theta = 0.05) to the gene of the autosomal dominant type. Close linkage (theta less than or equal to 0.20) between the locus of the marker and that of ARPKD can be excluded. These data strongly suggest that the loci for the autosomal recessive and dominant forms of polycystic kidney disease are not allelic.

Alleles↗
PubMed1984

Hemodiafiltration versus hemodialysis in children.

A total of 6 anuric children have been suitable treated with HD for 12 months and subsequently with HDF for 12 other months. Session time, tolerance and quality of epuration are compared in HD and HDF. Hemodiafiltration combining hemodialysis and hemofiltration in the same treatment time realizes in a short time (about 50% of hemodialysis session time) an optimal epuration with a good tolerance in children.

Anuria↗
PubMed1984

[Low caries activity and salivary pH in youngsters dialyzed for chronic renal failure].

Caries experience was studied in 18 young patients dialyzed for chronic renal failure and aged 7 to 17 years. The mean plaque index (Silness and Löe, 1964) was 1.89 +/- 0.15. Beside abundant plaque, these patients presented with poor oral hygiene and a food intake rich in sugars. Despite these unfavourable factors, caries experience was low. Of a total of 18 patients, ten (56%) had a DMF of 0. In addition, 11 subjects presented dental hypoplasias on more than two teeth. In these patients, the pH of whole saliva was determined at the beginning of the dialysis at time T and at the end of the dialysis at time To. The values at time T were always higher than those of time To. The mean pH at time T was 8.58 +/- 0.01 and the mean pH at time To was 8.09 +/- 0.01. These high salivary pH values are related to the low caries experience noted in these patients.

Adolescent↗