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Biomedical subjects

J Geissbühler

Publications and source records attributed to J Geissbühler.

5 recordsLinked to original sources

[Salmonella enteritis with a serious course in patients without a suppressed immune system].

Infections with salmonellae causing gastroenteritis rarely lead to bacteremia (1-4%), and serious courses are almost exclusively observed in patients with a compromised immune system. In 1986-1987 we observed 4 patients with no evidence of disturbed cell-mediated immunity, who presented with severe bacteremic salmonellosis (1 patient with S. Heidelberg and 3 with S. enteritidis). 1 patient had septic shock with rhabdomyolysis, 1 patient acute renal failure and 1 patient acute endocarditis.

Acute Kidney Injury↗

Nemaline myopathy appearing in adults as cardiomyopathy. A clinicopathologic study.

We examined a 29-year-old woman with nemaline myopathy that appeared as cardiomyopathy. Clinical examination showed dilated cardiomyopathy, but no neuromuscular abnormalities of the skeletal muscles. Electromyography showed neither neurogenic nor myopathic abnormalities. A biopsy specimen from the quadripecs muscle showed typical nemaline bodies in about 50% of the muscle fibers. The patient died six months later of biventricular heart insufficiency. Autopsy revealed nemaline bodies in the working and conducting tissues of the myocardium. Earlier, the patient's mother and one of her sisters died unexplained, sudden deaths at the ages of 47 and 37 years, respectively. Sections of the myocardium taken from the sister at autopsy were available, and also disclosed nemaline bodies after restaining with trichrome.

Adult↗