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Biomedical subjects

J Gillet

Publications and source records attributed to J Gillet.

At least 37 records · Page 2Linked to original sources
PubMed1986

alpha-Difluoromethylornithine induces protective immunity in mice inoculated with Plasmodium berghei sporozoites.

Mice inoculated weekly with Plasmodium berghei sporozoites while under treatment with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, developed protective immunity against subsequent challenge with this parasite. The percentage of mice protected was similar whether DFMO alone (55%) or DFMO + chloroquine (65%) was used. With chloroquine alone, only 12% of mice were protected. This protection was long-lasting (at least six months). The immunity protected against sporozoites but not against erythrocytic form inoculation. It is suggested that this protection is induced by antigens released from exoerythrocytic schizonts whose further development is inhibited by DFMO.

Animals↗
PubMed1981

Development of new derivatives of primaquine by association with lysosomotropic carriers.

On the basis of the drug-carrier concept of chemotherapy, we entrapped primaquine in liposomes, and linked it to an amino acid (leucine), and to peptides (alanyl-leucine and alanyl-leucyl-alanyl-leucyl) as intermediate steps in the synthesis of covalent primaquine-glycoprotein conjugates that would be selectively recognized by hepatocytes.The therapeutic activity of these compounds was tested in mice infected with sporozoites of Plasmodium berghei. Causal prophylatic cures were obtained after a single intravenous injection of primaquine-liposomes (60-70 mg of primaquine/kg of bodyweight) and lower doses (35 mg of primaquine/kg of bodyweight) of ala-leu-primaquine and ala-leu-ala-leu-primaquine.The administration of such high doses was only possible as a result of the decreased toxicity of primaquine when entrapped in liposomes and confirms the validity of the drug-carrier concept for the treatment of malarial infections. The improved chemotherapeutic index of ala-leu-primaquine and ala-leu-ala-leu-primaquine resulted from their decreased toxicity and increased chemotherapeutic activity. These peptide derivatives are probably acting as pro-drugs of primaquine.

Animals↗
PubMed1979

[Symptomatology in 162 patients with spasmophilia (chronic idiopathic or constitutional tetany). A statistical analysis using a computer (author's transl)].

A computer was used for a statistical analysis of the results of treatment in 162 patients (130 women and 32 men with an average age of 29 years), with chronic idiopathic tetany. Symptoms leading to diagnosis were mainly feelings of ill-health (27.2 %), motor disorders (19.7 %), and sensory problems (19.1 %). The onset of acute attacks is related, more especially, to psychogenic factors. The frequency of the various clinical manifestations, and their symptomatic grouping were analyzed. The clinical profile is similar in both sexes apart from 7 of the 89 items: lipothymia, abnormal feelings of warmth, pseudo-contraction of the larynx, abnormalities of the exoskeleton, and digestive disorders are more frequent in women, while precordalgia is more often present in men. Factorial analysis of correspondence between 38 variables reveals a very large dispersion of the variables, as the first three factors, which are the most significant, supply only 30% of the total information. Furthermore, very few variables share significant relationships in each factor. In spite of the amount of information collected, this dispersion of the symptomatology does not permit the definition of one or more profile-types of spasmophilia.

Acute Disease↗
PubMed1977

[Radiological appearances of hydatid cysts of the kidney. 10 confirmed cases (author's transl)].

Ten cases of hydatid cyst of the kidney are reported. The problem was invariably unilateral and isolated, involving the left kidney in 8 cases and the right kidney in 2 cases. IVP reveals a syndrome of a renal mass, sometimes enormous. Peri-cystic calcifications were visible in 7 cases, very localised in 5 cases and diffuse in 2. In 3 cases the kidney was non-functioning. No communication between the cyst and the excretory pathway could be seen at IVP in the two cases where it existed anatomically. Cystic parietography, partial or total, was visible in 4 cases. The mass was always avascular, without spur sign. The picture is very similar to that of a necrosed carcinoma of the kidney. Arteriography was not felt to be any more helpful than IVP in demonstrating the wall of the cyst. By contrast, changes in the trunk of the renal artery were common. The authors discuss the means avaliable for the radiological exploration of hydatic cysts of the kidney, in relation to the technical possibilities possessed in countries where the problem is endemic.

Adult↗
PubMed1975

[Influence of spermatogenesis on testicular fluid secretion in adult rats].

Unilateral efferent duct ligature mainatined for 24 h in adult Wistar rats, shows that the secretion of testicular fluid elevates progressively with the age of animals (from 10 mg/g/h at a 100 days to 13 mg/g/h at a 150 days). This technique when applied to rats in which spermatogenesis is temporarily inhibited by busulphan shows, by contrast with control animals, a change in the secretion of testicular fluid which is the converse of the variation of spermatogenesis.

Age Factors↗