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Biomedical subjects

J Gillissen

Publications and source records attributed to J Gillissen.

5 recordsLinked to original sources
PubMed1978

[Treatment of urinary-tract infections with netilmicin (author's transl)].

Netilmicin, a half-synthetic aminoglycoside, was given to 22 patients with urinary-tract infections at a dose of 2 mg/kg body weight twice daily intramuscularly for 7--9 days. Pharmacokinetics (in ten patients), efficacy and tolerance to the drug were analysed. Mean serum peak concentrations on the first and last days of treatment, was 8.7 microgram/ml at 45 min after injection, 9.5 microgram/ml after 60 min. After 12 hours the level had fallen to 0.8 microgram/ml and 1.2 microgram/ml, respectively. Mean half-life was 3.08 hours for the first and 3.57 hours for the last day. The corresponding mean values for plasma clearance were 53.6 ml/min and 42.4 ml/min, respectively. Within 12 hours an average of 77.6% and 78.0%, respectively, of the netilmicin dose were eliminated in the urine. The causative organism was eliminated in 12 of 16 patients with chronic or reccurent and in all six with acute urinary infections. There were two re-infections and two failures. Superinfection did not occur. Local and general tolerance was good and there were no signs of renal or inner-ear toxicity.

Adult↗
PubMed1976

[Sisomicin treatment of urinary tract infections (author's transl)].

In a study with 30 randomized patients the pharmacokinetics, efficacy and side effects of Sisomicin were determined. Half of the patients received one single intramuscular injection of 75 or 100mg (1.4 mg/kg) Sisomicin/day. The other cases were injected 50 or 75mg (1.9 or 2.1 mg/kg) b.i.d. The serum concentrations determined on the first and last days of treatment 1 hour after the application ranged between 4 and 5.3 mug/ml. After 6 hours the values decreased to 0.7-0.8 mug/ml. The elimination rate within 24 h amounted to 63-77%. Depending on the dosage group, the mean urinary concentrations/24 h amounted to 46-51 mug/ml or 63 to 92 mug/ml, respectively. The highest concentration measured during the first 8 hours amounted to 129 mug/ml after an administration of 1.4 mg/kg. In 18 of 29 cases a "cure" of urologic infections, most of which had been treated previously without success, could be achieved. Furthermore we observed 5 relapses, 3 failures and 3 reinfections, but no superinfection. The local and general tolerance of Sisomicin was good. 5 patients showed toxic reactions of the vestibular organ in the form of dizziness. In 1 case there was an excretion of granulated casts.

Adolescent↗
PubMedDate not supplied

Clinical experience with aztreonam in Germany and Austria.

Of 146 hospitalized patients treated with aztreonam for infections, primarily of the urinary and lower respiratory tracts, 142 had a satisfactory clinical response. An initial microbiologic cure was found in 106 (84%) of 126 patients. Relapse, reinfection, or superinfection occurred in 28 patients. Thirty-nine of 43 patients treated with a control drug (gentamicin, cefotaxime, cefamandole, or tobramycin) had a satisfactory clinical response, 25 of 34 such patients showed microbiologic cure, and 12 experienced relapse, reinfection, or superinfection. Short-term perioperative treatment with aztreonam in male patients whose urine was positive for gram-negative organisms was successful for 10 of 11 patients. Pharmacokinetic studies demonstrated that dosage adjustment of aztreonam in geriatric patients should be based on creatinine clearance. No nephrotoxicity was demonstrated in 10 healthy male volunteers. Satisfactory concentrations of aztreonam were found in sputum, vagina, cervix, perimetrium, myometrium, endometrium, parametrium, fallopian tube, fat, muscle, and kidney tissues.

Adult↗