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Biomedical subjects

J Gjessing

Publications and source records attributed to J Gjessing.

10 recordsLinked to original sources

Hypercapnia and hyperkalaemia.

Studies in patients undergoing peritoneal laparoscopy, in which carbon dioxide was used as insufflating gas, showed that artificial hyperventilation was an effective means of preventing serious hypercapnia. The hypercapnia caused a rapid hyperkalaemia and there was a linear relationship between the two. Reversal of the hypercapnia caused the serum potassium to fall towards normal but the speed of this fall did not match the speed of reduction in Paco2. It is suggested that the changes in serum potassium following changes in Paco2 may have some clinical relevance in potassium-depicted patients.

Adult

Balanced regional analgesia--an hypothesis.

An hypothesis is advanced, based upon observation of patients undergoing selected types of regional analgesic blocks, that total patient care during any regional analgesic technique consists of maintaining a balance of local analgesia, tranquillity and the use of a centrally acting analgesic. The latter is required to relieve non-specific distress unrelated to the operation which appears to be caused by a disturbance of sensory input to the cerebral cortex, possibly the proprioceptive input. A small group of patients will not respond to any sedation accompanying regional analgesia and need general anaesthesia. It is suggested that failure to appreciate all three parts of this triad may contribute to uncertainty of patient control during regional block.

Anesthesia, Conduction

An unusual solvent.

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Anesthesia, Epidural

Intravenous sedation and regional analgesia.

A double-blind study of 229 patients with the use of intravenous diazepam as compared with a placebo to produce sedation during local analgesia showed that significantly improved sedation occurred when diazepam was used. The diazepam was dissolved in cremophor and this reduced the pain of intravenous injection of the diazepam. One patient who received Cremophor only, showed a moderately severe allergic reaction. It is suggested that a small test dose should always be given before giving any drug which is dissolved in Cremophor.

Adolescent

A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia.

A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia, peritoneal dialysis using a cold dialysate, is described. Experimental observations in a young man on a regular peritoneal dialysis regime showed that significant heat extraction can be obtained when either a cool (20 degrees C) or cold (9 degrees C) dialysis fluid is used. The maximum heat exchange observed was 17.5 kJ/min when 2 litre of cold dialysis was instilled for a mean time of 10 min. This rate of heat exchange is within the 10--40 kJ/min range of excess heat production that occurs in malignant hyperpyrexia. Since peritoneal dialysis is, technically, a very quick and simple procedure, it is suggested that it might play a very useful role in the emergency treatment of malignant hyperpyrexia. The dialysis treatment would also correct some of the biochemical disturbances that occur in this condition.

Anesthesia, General

Acute appendicitis and continuous peritoneal lavage.

In a series of 117 patients of all ages who were found to have acute appendicitis with perforation, it was found that continuous peritoneal lavage started immediately after appendicectomy had a significant effect in reducing the morbidity and complication rate of this condition. The treatment lasted on average 18 hours and approximately 40 litres of dialysate were used per patients. Treatment was continued until the effluent was macroscopically clean.

Acute Disease