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Biomedical subjects

J Gloster

Publications and source records attributed to J Gloster.

At least 19 recordsLinked to original sources
PubMed1986

Association between optic disc haemorrhages in glaucoma and abnormal glucose tolerance.

Data concerning the results of glucose tolerance tests and levels of intraocular pressure were analysed for 120 patients with primary open-angle glaucoma, many of whom had been under observation for a period of four to five years. The patients consisted of two groups: in 62 patients a disc haemorrhage had been recorded at some time during the observation period, and in 58 no haemorrhages had been seen. Patients with disc haemorrhages had a higher incidence of abnormal glucose tolerance or frank diabetes and lower intraocular pressures than those without haemorrhages.

Adult↗
PubMed1984

Analysis of a series of outbreaks of Aujeszky's disease in Yorkshire in 1981-82: the possibility of airborne disease spread.

A series of outbreaks of Aujeszky's disease occurred in Yorkshire during 1981-82. These were investigated from epidemiological and meteorological viewpoints to determine if airborne disease spread could have occurred between any of the premises. The results suggest that seven out of the 11 outbreaks investigated could have resulted from airborne virus.

Air Microbiology↗
PubMed1982

Long distance transport of foot-and-mouth disease virus over the sea.

The conditions required for the transport of foot-and-mouth disease (FMD) virus in the atmosphere over long distances and in sufficient concentrations to cause infection in exposed animals are described. Using these factors a series of 23 outbreaks of FMD in Europe, where the original outbreaks were separated from later outbreaks by sea passage, have been investigated. The findings obtained support the hypothesis that under certain conditions the airborne transmission of FMD over a long sea passage is possible.

Air Microbiology↗
PubMed1982

Use of prediction models to forecast and analyse airborne spread during the foot-and-mouth disease outbreaks in Brittany, Jersey and the Isle of Wight in 1981.

Between March 4 and 26, 1981 the French veterinary authorities reported a series of 14 outbreaks of disease due to type O foot-and-mouth (FMD) virus, 13 in Brittany and one in Normandy. The United Kingdom reported FMD type O in Jersey on March 19 and in the Isle of Wight on March 22. The field and laboratory investigations on the farm in the Isle of Wight are outlined. The way in which short and long range numerical models were used to forecast the airborne spread of FMD from Brittany to the UK and then to assess the risk of further airborne spread within the UK is described.

Air Microbiology↗
PubMed1982

Air sampling of pigs infected with foot-and-mouth disease virus: comparison of Litton and cyclone samplers.

The air in looseboxes containing groups of pigs in the acute stage of foot-and-mouth disease was sampled simultaneously with two air-sampling devices: a large volume sampler (Litton) and a cyclone sampler. Although the cyclone sampler was slightly less efficient at trapping airborne virus it was easier to operate. When pigs were sampled individually within a 610 litre cabinet using the cyclone sampler, the mean recovery of virus over a 24 hour period was log10 8 X 6 TCID50 per animal. This figure is four times higher than the maximum amount estimated in previous studies in which groups of pigs held in looseboxes were sampled with a Litton apparatus.

Air Microbiology↗
PubMed1981

Incidence of optic disc haemorrhages in chronic simple glaucoma and ocular hypertension.

1829 photographs of optic discs taken during routine examination and follow-up of 320 glaucoma patients and 169 cases of ocular hypertension were examined for the presence of haemorrhages on the disc. As expected, the observed incidence of disc haemorrhages rose with increase in the number of occasions on which the patient was photographed. It was concluded that at least one-third of glaucoma patients show a disc haemorrhage at one time or another. Disc haemorrhages were seen more often in patients with established glaucoma than in those with ocular hypertension. In patients with chronic simple glaucoma eyes with full fields and low cup: disc ratios showed haemorrhages less often than eyes with field defects and more advanced damage to the optic disc, but apart from this there was no marked tendency for haemorrhages to occur at a particular stage of the disease. Haemorrhages were more frequent in low-tension than in chronic simple glaucoma, but this was probably only part of a more general variation which was revealed when eyes were graded according to the maximum pressures ever recorded, there being a very significant trend in which more haemorrhages were found in eyes with lower than with higher intraocular pressures over the range from 10 to 60 mmHg.

Glaucoma↗
PubMed1980

A long term study of low concentration guanethidine and adrenaline therapy in glaucoma.

A long term study was undertaken to evaluate the efficacy of combined guanethidine (1%) and adrenaline (0.05-0.5%) therapy in controlling intra-ocular pressure in 89 patients with chronic open angle glaucoma, in whom ocular tensions proved difficult to control on miotics and/or carbonic anhydrase inhibitors. Visual acuity, fields of vision, applanation tension, size of the pupil, anterior chamber depth and gonioscopic examination of the angle were recorded before and during treatment. The follow-up extended over a period of 12 to 42 months, the mean being 28 months. The combined therapy was found to lower the intra-ocular pressure significantly in a large number of patients and the most potent combination was guanethidine 1% and adrenaline 1/4% and the average fall of intraocular pressure with the combined therapy was around 8 mm Hg. Intolerance to the combined preparation was noticed in three patients during a period of 12-18 months with the symptoms of sore eyes, conjunctival hyperaemia and lid irritation of such severity that the treatment had to be withdrawn. Resistant to treatment developed in four patients during a period of 12-36 months and treatment had to be changed. Addition to guanethidine (1%) and adrenaline up to 1/4% to pilocarpine therapy (2-4%) in eyes with narrow angles did not result in any appreciable change of the width of the angle, the size of the pupil and the depth of the anterior chamber.

Adult↗
PubMed1980

The Northumberland epidemic of foot-and-mouth disease, 1966.

The spread of foot-and-mouth disease during an epidemic in Northumberland in July, August and September 1966 was analysed. Although strong emitters, for example pigs, were not involved, in 18 of the 32 outbreaks spread could be attributed to the airborne route and in another 4, spread by this route was the most likely. Airborne spread was in general between 1 and 8 km but on two occasions as much as 20 km. Other means of spread included movement by animals, people and vehicles and carriage of virus between animals in neighbouring fields. No spread by milk or milk lorries took place. Sheep were involved in 9 farms; on each, lesions older than 48 h were found and it is likely that the sheep were the source of virus for other animals, especially cattle, on the farm and on neighbouring farms. The analysis suggests that control measures such as slaughtering direct contacts, as used in this epidemic, or ring vaccination as well as movement control would be effective in limiting spread.

Animals↗
PubMed1980

Colour vision in patients with chronic simple glaucoma and ocular hypertension.

Normal subjects and patients with chronic simple glaucoma and ocular hypertension were examined with the Farnsworth-Munsell 100 hue test. Two groups of glaucoma patients were studied, one group having field defects in both eyes and the other being 'unilateral' in the sense that one eye had a full visual field. The stage of the disease was assessed by the amount of field loss or by the amount of optic disc damage as expressed by the vertical cup:disc ratio. Hue discrimination in eyes with glaucomatous field defects was worse than in eyes of normal subjects, but there was no clear indication of one range of colours being more affected than another. In glaucoma patients with field defects in both eyes the difference in error scores between the 2 eyes was greater than in normal subjects. There was a significant correlation between the degree of impairment of hue discrimination, expressed as the error score, and the amount of glaucomatous field loss. There was also a significant correlation between error score and the amount of glaucomatous damage to the optic disc, expressed by the vertical cup:disc ratio. Findings in a group of patients with ocular hypertension suggested that some of these were cases of incipient glaucoma.

Chronic Disease↗
PubMed1979

Gas liquid chromatographic studies of [1-14C] palmitate uptake by the perfused guinea-pig heart.

In addition to the uptake of palmitate by the isolated perfused guinea-pig heart, there was a substantial release of longer chain fatty acids into the perfusate amounting to about 50% of the uptake of palmitate. Both the uptake of palmitate and the release of other fatty acids was diminished in the presence of 95% N2. The specific activity of myocardial palmitate was increased under 95% N2. No significant difference in the distribution of radioactivity between the different myocardial fatty acids occurred between 95% O2 and 95% N2.

Animals↗
PubMed1978

Quantitative relationship between cupping of the optic disc and visual field loss in chronic simple glaucoma.

The extent of cupping was measured from optic disc photographs of 300 patients with ocular hypertension and suspected or established chronic simple glaucoma, and their visual fields were recorded. The incidence of field defects increased as the vertical cup:disc ratio increased, a value of 0-70 for this ratio being a particularly useful guide to the presence or absence of field loss. There was a significant correlation between the extent of cupping and the size of the visual field. The vertical cup:disc ratio was the most useful quantitative index of cupping.

Anthropometry↗