PubMed Health⌕ Search

Biomedical subjects

J Godard

Publications and source records attributed to J Godard.

At least 19 recordsLinked to original sources
PubMed2003

Intracerebral alveolar echinococcosis.

There are two species of the genus Echinococcus, Echinococcus multilocularis (also called alveolar hydatid) and Echinococcus granulosus, characterized by distinct growth features in humans. The main endemic regions for human alveolar echinococcosis (AE) caused by E. multilocularis are Central Europe, Russia, Turkey, Japan, China, eastern France and North America. Human echinococcosis is usually caused by an intrahepatic growth of parasitic larvae. Cerebral occurrence of E. multilocularis disease is rare, accounting for only 1% of cases, and is generally considered to be fatal. This report presents two cases of intracerebral E. multilocularis disease which occurred in two infected patients with AE pulmonary metastases. The anatomical and clinical features are discussed. Our retrospective survey would indicate that surgical treatment should be envisaged whenever possible.

Adult↗
PubMed2003

[Use of polyester urethane (Neuro-Patch) as a dural substitute. Prospective study of 70 cases].

Between October 1995 and March 1998, 70 patients were treated with a microporous polyester urethane dura substitute (Neuro-Patch), after brain or spinal surgery. These patients were assessed clinically and radiologicaly 10 days, 6 weeks and 1 year after surgery. Radiological evaluation used CT scan or MRI. All dura substitutes were fixed by continuous suture to the surrounding dura-mater. We studied the handling properties, the incidence of infection and of CSF leakage. Eleven patients underwent craniotomy again. This gave us the opportunity to examine the adhesion to the brain tissue and the integration of the dura substitute. Six sheets underwent histological examination. Our results show good handling properties of the material; 3 infections; 6 out of 9 radiological CSF leakage occurred from infratentorial surgery. During reoperation, no adhesion to the brain tissue or injury to the brain while detaching the dura substitute was noticed. An excellent histological integration was observed: pores of the Neuro-Patch were colonized by fibroblasts synthesizing collagen, and there was no immune or inflammatory reaction, with an actual 4 to 6 years follow-up. A Neuro-Patch can therefore be recommended as a dura substitute to repair spinal or cranial dural defects.

Adolescent↗
PubMed2001

Evaluation of caudal anaesthesia performed in conscious ex-premature infants for inguinal herniotomies.

Ex-premature infants, before 45 weeks postconceptional age, are at high-risk of apnoea after surgery. General anaesthesia increases the risk of apnoea. We evaluated the tolerance and the efficiency of caudal anaesthesia performed in 25 consecutive conscious ex-premature infants for inguinal herniotomies. N2O/O2 and EMLA cream are used to facilitate caudal puncture. Anaesthesia procedure, patient comfort and complications following the 24 postoperative hours were studied. We report good anaesthesia conditions without compromising the baby's comfort and few perioperative complications. Only two infants with a prior history of apnoea or bronchopulmonary dysplasia had apnoea during and after surgery. A total spinal anaesthesia was the major complication in one infant and prolonged surgery requiring general anaesthesia was the main limitation of this technique in another child. The principal advantage of the procedure is to facilitate and simplify the postoperative management of the babies. The anaesthetic technique does not alter surgical conditions. Caudal epidural anaesthesia performed in awake high-risk preterm infants is beneficial for these infants but requires experienced operators.

Anesthesia, Caudal↗
PubMed2000

High frequency oscillatory ventilation during repair of neonatal congenital diaphragmatic hernia.

We evaluated the use of high frequency oscillatory ventilation (HFOV) during congenital diaphragmatic hernia repair. After preoperative stabilization, 22 newborn infants were ventilated with HFOV during surgery. Ventilatory settings, blood gas values and oxygenation index were recorded before, during and after surgical repair. No differences were noted for these variables. No complications related to ventilation were recorded. According to the surgeon, diaphragmatic repair during HFOV is facilitated. This study confirms that CDH can be safely repaired using HFOV during anaesthesia.

Analysis of Variance↗
PubMed2000

[Intramedullary spread of a cerebral oligodendroglioma. Two case reports].

We report two cases of leptomeningeal metastatic dissemination to the spinal cord of a grade B oligodendroglioma. Diagnosis was suspected on MRI but imaging findings were nonspecific. The pathways by which the intramedullary part of the spinal is reached by metastatic cells remains controversial. In the reported cases, both frontal and cystic primary intracerebral lesions were observed. Chemotherapy after radiotherapy appears to improve outcome. Nevertheless, prognosis remains very poor.

Abducens Nerve Diseases↗
PubMed1998

The hemodynamic effects of pneumoperitoneum during laparoscopic surgery in healthy infants: assessment by continuous esophageal aortic blood flow echo-Doppler.

UNLABELLED: Cardiovascular changes due to pneumoperitoneum during laparoscopic surgery are established in adult patients, but not known in infants. We investigated the hemodynamic effects of laparoscopy during general anesthesia in 12 ASA physical status I infants by using noninvasive continuous esophageal aortic blood flow (ABF) echo-Doppler monitoring. During the laparoscopic procedure, intraabdominal pressure was maintained automatically at 10 mm Hg by a CO2 insufflator, and minute ventilation was adjusted to avoid hypercapnia. Hemodynamic changes were continuously recorded on soft magnetic support and assessed at three time intervals: t0 (after the initiation of anesthesia), t1 (5 min after peritoneal insufflation), and t2 (5 min after exsufflation). The induction of pneumoperitoneum resulted in a significant decrease in ABF and stroke volume, and in a significant increase in systemic vascular resistance, compared with control values: 67% +/- 9% (P < 0.001), 68% +/- 10% (P < 0.001), and 162% +/- 34% (P < 0.001), respectively. These changes were completely reversed after peritoneal exsufflation. Pneumoperitoneum caused no significant changes in mean arterial pressure or in end-tidal CO2 pressure. These findings demonstrate that laparoscopy is associated with hemodynamic changes without clinically deleterious consequences in healthy infants during a short duration of pneumoperitoneum. IMPLICATIONS: The peritoneal insufflation achieved during laparoscopic surgery is associated with cardiovascular impairments (decrease in cardiac performance and increase in vascular resistance). We found that these changes had no clinically deleterious effects in healthy infants.

Aorta↗
PubMed1997

Odontoid fractures in the child with neurological injury. Direct anterior osteosynthesis with a cortico-spongious screw and literature review.

Few cases of fracture of the odontoid process in children have been reported in the literature. A case with an associated severe traumatic brain injury and a suspected clinical high cervical spinal cord injury is reported here. This case is of interest because of the surgical treatment selected. A direct surgical approach was used for anterior screwing, with an excellent result. In some precisely defined circumstances, therefore, this treatment can be indicated.

Bone Screws↗
PubMed1997

[3-dimensional (3D) echography in obstetrics. Advantages and limits].

Three-dimensional ultrasound (3D) offers new options in imaging modes: such as simultaneous rotation and translation of the three perpendicular planes displayed, surface rendering, or transparent mode providing an imaging of structures with high echogenicity (bones, skull). This new imaging mode is extending the field of conventional two-dimensional ultrasound, but for now it has to be evaluated.

Endosonography↗
PubMed1996

Patent foramen ovale: association between the degree of shunt by contrast transesophageal echocardiography and the risk of future ischemic neurologic events.

This study investigated whether there is an association between the degree of interatrial shunting across a patent foramen ovale, as determined by saline contrast transesophageal echocardiography, and the risk of subsequent systemic embolic events, including stroke. Thirty-four patients found to have foramen ovale during transesophageal echocardiography were divided into two groups on the basis of the maximum number of microbubbles in the left heart in any single frame after intravenous saline contrast injection: group 1 (n = 16) with a "large" degree of shunt ( > or = 20 microbubbles) and group 2 (n = 18) with a "small" degree of shunt ( > or = 3 microbubbles). Patients were followed up over a mean period of 21 months for subsequent systemic embolic events, including transient ischemic attack and stroke. Five (31%) of the patients with large shunts had subsequent ischemic neurologic events, whereas none of the patients with small shunts had embolic events (p = 0.03). These events occurred in spite of antiplatelet or anticoagulant therapy. We conclude that patients with a large degree of shunt across a patient foramen ovale, as determined by contrast transesophageal echocardiography, are at a significantly higher risk of subsequent adverse neurologic events compared with patients with a small degree of shunt.

Anticoagulants↗
PubMed1995

[Pain in hospitalized children].

Pain is present in many hospitalized children and this requires from every physician a constant attention to its recognition, evaluation and treatment. The semeiology of pain differs whether it is acute or chronic. Acute pain can be recognized from its various behavioural, motor and neurovegetative manifestations. Pain evaluation must be adapted according to age: autoevaluation procedures for children older than 5 years, behavioural scales for children younger than 5 years. One must know that there is an appropriate and efficient treatment for each stage of pain intensity. For a better recognition and management of pain in hospitalized children, the organization of teams specialized in the evaluation and treatment of pain in children is to be encouraged.

Child↗
PubMed1994

[Nosocomial pneumonia in intensive care. Value of different diagnostic tools].

The authors analyzed in published studies providing histologic data the value of diagnostic means of nosocomial bronchopneumonia (NBP) in critically ill patients. At least 10% of patients whose trachea is intubated and the lungs mechanically ventilated suffer an histologically-confirmed NBP. Histology of NBP consists of non systematized foci of infection, localised in 90% of cases in the posterior segments of the lower pulmonary lobes. In fact, small foci are disseminated in both lungs, usually within large areas of non infectious pulmonary lesions and are often multimicrobial. This may explain why the clinical and radiological diagnosis is inaccurate in more than 40% of cases. On chest X-ray, aeric bronchogram and alveolar infiltrates are suggestive but non-specific for NBP, as are also fever, leukocytosis and purulent sputum. Therefore, to confirm the diagnosis of infection and to isolate the microorganisms responsible for NBP, additional investigations are required whose interpretation is uneasy. In a simplified manner, bacteriological inoculum takes a course parallel to the histological bronchopulmonary lesions: no bacteria in the absence of infection, high bacterial inoculum in case of confluent NBP, intermediary in case of bronchitis, however with exceptions when antibiotherapy has recently been modified. In fact, neither bronchial protected brushing nor broncho-alveolar lavage techniques have a perfect sensitivity and specificity. As an example, a diagnostic procedure in assessed in calculating the probability of an accurate diagnosis of NBP. It is concluded that diagnosis of ventilator-associated pneumonia remains still unreliable with the means available today.

Bronchoalveolar Lavage Fluid↗
PubMed1994

Effects of magnesium supplementation in a porcine model of myocardial ischemia and reperfusion.

We tested the hypothesis that acute, intravenous (i.v.) magnesium (Mg2+) supplementation would protect against myocardial stunning in an in situ swine model of regional ischemia and reperfusion and that a concomitant inhibitory effect on platelet aggregation would be elicited. An open-chest model was used, with transient occlusion of the left anterior descending coronary artery (LAD) for 8 min. Regional contractile function was assessed by measuring wall thickening fraction with epicardial Doppler crystals. One control group (n = 6) and two treatment groups were studied: group I (n = 6) received 750 mg MgSO4 before occlusion; group II (n = 6) received 1 g MgSO4 after the occlusion. Both protocols produced significant hypermagnesemia. In group I, platelet aggregation was measured before and after Mg2+ treatment using platelet-rich plasma (PRP) and various agonists (ADP 5 and 10 mM and collagen 1 mg/ml). As compared with controls, both treatment groups experienced significantly less postischemic dysfunction, with systolic function returning more quickly to baseline. Furthermore, platelet aggregation was significantly decreased immediately after Mg2+ infusion. Inhibition of platelet aggregation induced by Mg2+ treatment occurs concomitantly with significant amelioration of postischemic myocardial dysfunction.

Animals↗