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Biomedical subjects

J Goni

Publications and source records attributed to J Goni.

17 recordsLinked to original sources
PubMed1991

[Influence of Chlamydiae serology and the presence of a pelvic inflammatory state on the results of in-vitro fertilization].

The authors investigated the influence of Chlamydiae serology and the presence of a pelvic inflammatory state on the outcome of in-vitro fertilization on the basis of an analysis of 116 stimulation cycles. The study included 71 female patients suffering from infectious sterility of tubular origin with distal lesions. Chlamydiae trachomatis serology was considered to be positive at IgG titers in excess of 1/64. When the serum test was positive, there was a significant reduction in the number of clinical pregnancies and the cleavage rate. The percentage of ectopic pregnancies (6 ectopic pregnancies out of 29 clinical pregnancies) was very high, particularly if the serum test was positive and a pelvic inflammatory state persisting after antibiotic treatment contraindicated microsurgery. Surgery was performed only in favorable cases and did not appear to have any negative impact on the outcome. The presence of a non-stabilized pelvic infectious state was correlated with a significant increase in the drop-out rate and the number of post-menopausal gonadotropin required to achieve stimulation. The fact that unexpected spontaneous pregnancies may occur after an unsuccessful attempt must be taken into account when sterilization or salpingectomy are envisaged in an attempt to improve the outcome.

Chlamydia Infections↗
PubMed1981

Mesotheliomas in rats following inoculation with acid-leached chrysotile asbestos and other mineral fibres.

The carcinogenicity of untreated UICC chrysotile A, of acid (oxalic and hydrochloric)-leached UICC chrysotile A, of crocidolite and of JM 104 glass fibres has been studied by intrapleural injection into rats. This experiment, carried out on 304 animals, demonstrated that when more than 80% of the Mg had been leached from chrysotile fibres by either hydrochloric or oxalic acid, the proportion of pleural mesotheliomas was either nil or dramatically lower than that obtained with untreated chrysotile. The carcinogenic effect of crocidolite was higher than that of 43.7% oxalic acid-leached chrysotile. The proportion of mesotheliomas observed in animals injected with JM 104 glass fibres was similar to that in animals injected with fibres from which 63.8% had been leached with oxalic acid. These results indicate that with regard to the induction of pleural carcinogenicity by chrysotile fibres, not only size characteristics but also parameters such as chemical composition and physiochemical properties must intervene.

Animals↗
PubMed1980

Effects of well-defined fibres on red blood cells and alveolar macrophages.

The fibres used in this experiment were UICC asbestos fibres (chrysotile, amosite, crocidolite, either untreated or leached with oxalic acid), nemalite and glass fibres. Chrysotile was also treated with sulfur dioxide. Size distribution measurements by electron microscopic analysis, chemical analysis and measurement of specific surface area were performed. Haemolytic activity was studied in human red blood cells by kinetic analysis of the percentage of haemoglobin released; this generated information on the shape of the curve, the initial velocity of the haemolysis and the maximal haemolysis. The effect on rabbit alveolar macrophages was determined in vitro by the measurement of lactic dehydrogenase and beta-galactosidase released from alveolar macrophages cultured with the fibres. Amphiboles and chrysotile had opposite reactivities on red blood cells. Leaching did not change the shape of the curve with chrysotile whereas it modified that with amphiboles. The initial velocity decreased with leached chrysotile and increased with leached crocidolite or amosite. Maximal haemolysis was linearly dependent on the fibre concentration with amosite and crocidolite, but not with chrysotile or nemalite. The adsorption of sulfur dioxide onto chrysotile did not highly modify its haemolytic activity. In alveolar macrophages, chrysotile and leached amphiboles selectively released beta-galactosidase; and leached chrysotile and nemalite released both enzymes studied.

Animals↗
PubMed1980

Surface interaction between chrysotile and solutions (dissolution and adsorption): systematic x-ray photoelectron spectroscopy studies.

To test the reactivity of asbestos in relation to its physical and structural properties, surface analysis was made by X-ray photoelectron spectroscopy. The dissolution kinetics of chrysotile in strong reagents demonstrate two rate-limiting steps for the reaction: Mg2+ diffusion and chemical reaction. In some components of the Krebs cycle and in dilute hydrochloric and in oxalic acids, the reaction is limited by the exchange of Mg2+ in the first mineral layer. The interaction of model phospholipid membranes with chrysotile fibres was also studied; the results are in good agreement with the hypothesis of bilayer adsorption. Photoelectron data for adsorption of ghosts indicate that both proteins and phospholipids must be adsorbed onto chrysotile fibres.

Asbestos↗