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Biomedical subjects

J González Hachero

Publications and source records attributed to J González Hachero.

At least 19 recordsLinked to original sources
PubMed1997

[Vertical transmission of hepatitis C virus].

OBJECTIVE: The objectives of this study were to know the prevalence of hepatitis C virus (HCV) in a population of pregnant women, to evaluate the vertical transmission rates of HCV in a prospective study and to determine the repercussions and consequences in children born to infected mothers. PATIENTS AND METHODS: A total of 6556 pregnant women were tested for HCV antibodies from January 1993 to August 1995. We followed 50 babies born to infected mothers for at least 12 months (mean 15 months). Serological assays employed included a screening ELISA II confirmed with immunoblot. Viral detection was performed by qualitative and quantitative PCR for HCV-RNA. RESULTS: Fifty-nine pregnant women were AcHCV(+). This represents a seroprevalence of 0.9%. Of the 50 babies followed, 6 were PCR(+) and 44 were PCR(-). The risk of transmission is correlated with the titer of HCV-RNA in the mother. All mothers of infected babies were HIV (-). CONCLUSIONS: The rate of prevalence in our pregnant women population is 0.9%. We found a vertical transmission rate of 12%. The high serum HCV-RNA titers in the mothers are a risk factor of transmission of HCV. The viremia in the children does not predict the apparition of the clinical disease, although they can exhibit intermittent increases of transaminases.

Female↗
PubMed1996

Low bone mineral density in small for gestational age infants: correlation with cord blood zinc concentrations.

Twenty eight term small for gestational age (SGA) infants and 18 term appropriate for gestational age (AGA) infants were studied prospectively to assess bone mineral density and cord serum zinc concentrations. Growth and nutritional status were evaluated, and bone mineral density was measured by dual energy x ray densitometry of the lumbar spine. Cord serum zinc, parathyroid hormone, osteocalcin, vitamin D metabolite and mineral concentrations were measured. Growth, nutritional status, and bone mineral density (mean (SD) 0.223 (0.032) vs 0.277 (0.032) g hydroxyapatite/cm2) were significantly low in SGA infants. Bone mineral density was linearly related to growth and nutritional measures. Cord serum zinc concentrations were in the normal range and similar in both groups (mean (SD) 13.86 (3.0) vs 13.43 (2.1) mumol/l). It is suggested that SGA infants may not be zinc deficient. Low bone mineral density could be caused by growth and nutritional status deficiencies, the mechanisms for which could be those that reduce nutrient substrate supply to the fetus.

Bone Density↗
PubMed1993

[Acute meningococcal disease. Its prognostic assessment].

We have studied 50 children affected with acute meningococcal disease (AMD). The ages of the children varied between 4 months and 12.58 years, with a mean age of 4.58 years. By using the shock state and DIC syndrome, both of which are indications of the severity of the illness, an evaluation of the discriminatory capacity was done with regard to significantly associate variables and 3 scores, Bjorvatn, Leclerc and PRISM, throughout 8 intervals within the first 48 hours of hospital treatment. We observed a very high survival rate (98%) associated with the early treatment for shock. Leukopenia and disseminated purpura were the best variables in order to discriminate shock and DIC, respectively. The greatest capacity for the diagnosis of the shock state and DIC syndrome were registered during the 0-6 hour period and the 0-12 hour period, respectively. The prognosis improved if the child remained alive 12 hours after the treatment had begun.

Acute Disease↗
PubMed1992

[Acute meningococcal disease. Study of auditive sequelae].

We have examined the auditory function in 49 children that have survived an acute meningococcal disease (AMD). Functional auditory exploration consisted of: ABR; tonal liminal audiometry or behavioral audiometry (Peep-show method, Suzuki-Ogiba ROC) depending on the age and collaboration of the patient; and impedanciometrical techniques (tympanometry, ipsi and contra-lateral stapedial reflex). Three months later, altered tests were repeated in patients that had been evaluated at a time greater than 90 days after their first day of hospitalization (n = 18). All tests were repeated in those patients that had been evaluated before 90 days from the first day of hospitalization (n = 31). No transmission or neurosensory hearing impairments were detected as a result of AMD. We consider the absence of neurosensory hearing impairment, despite the presence of significant risk factors, an important finding. These results suggest that the risk of hearing impairment could be reduced to a minimum by the early establishment of antibiotic treatment.

Acoustic Impedance Tests↗
PubMed1991

[A study of cerebral blood flow in preterm newborns. The physiologic modification of diastole].

An evaluation of cerebral blood flow (CBF) was carried out with a Toshiba Sonolayers-S SSH-60 A echography in 127 infants with open major fontanelle which were divided in 3 groups: a) 69 non premature newborn, in which a physiological variation of all CBF parameters was found; b) 29 neurologically normal preterm infants, where the resistance index always was higher than in the preceding group, at the expense of a lower diastolic flow, in which for the first time the "physiological variation of diastole" independent of the gestational age is reported. This variation results in changes in the cerebral flow in the situations of exercise, rest or stress; c) 29 preterm infants with some abnormality, who also showed the physiologic variation of diastole with a poor flow quality were found.

Blood Flow Velocity↗
PubMed1987

[Effectiveness and tolerance of the treatment of infantile bronchial asthma with soluble and delayed-action theophylline].

Twenty-seven asthmatic children have been studied in the phase between crises. According to treatment they have been grouped in treated with soluble theophylline and treated with retard theophylline. Initial oral dose was for both groups of 16 mg/kg/day. Three stages have been considered in every patient: control, at 7 days and at 21 days, performing at each time a clinical (symptoms), functional (spirometry) and analytical evaluation (theophylline blood levels). Following results were obtained: Both frequency and intensity of clinical symptoms are progressively reduced along the study. This reduction is more apparent with retard theophylline, that shows a positive significant correlation (p less than 0.05) between blood level-forced vital capacity after 7 days and blood-level-peak flow after 21 days. Incidence of undesired drug effects is comparable in both groups. The number of children showing no adverse drug effects was greater in group of retard theophylline, however, number of adverse drug effects child was greater in this group. Theophylline mean doses required to attain clinical efficacy are similar in both groups. Neither soluble nor retard theophylline provide a mean blood level in therapeutic range after 7 days, however retard theophylline does so after 21 days.

Asthma↗