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Biomedical subjects

J Gougeon

Publications and source records attributed to J Gougeon.

At least 19 recordsLinked to original sources
PubMed1987

[Value of discography in disk punctures in bacterial spondylodiscitis].

26 discographic examinations were performed during puncture of 28 intervertebral disks for septic spondylitis. Discography assures the operator that the diagnostic needle is correctly inserted in the intervertebral disk, without destroying the causative microorganisms. But, in particular, this examination reveals the presence of lesions which often are not suspected within the vertebra or the adjacent soft tissue, and notably the presence of large and frequently occurring pyogenic abscesses. Because of this capacity, this test has a certain diagnostic value in case of recent spondylitis and with erosive disk disease. This simple and safe procedure, in our opinion, justifies its routine utilization at the same time as disk puncture is performed for bacteriological assessment of infectious spondylitis.

Bacterial Infections↗
PubMed1985

[Extramedullary arteriovenous fistula of the spinal canal with spinal cord venous drainage. Apropos of 2 cases].

The authors report two cases of extramedullary arteriovenous fistulas in the spinal canal with venous return into the spinal cord veins. Both patients were middle-aged men who presented with multiple nerve root involvement of the lower extremities for one year and three months respectively. Myelography demonstrated an indentation at the level of the conus medullaris by a dilated vein in both cases. Arteriography of the spinal cord demonstrated an arteriovenous malformation from the dura mater with venous return into the ascending spinal cord veins, located in both cases at T11. Unlike typical angiomas of the spinal cord, these arteriovenous fistulas do not arise from spinal cord arteries. Only the venous return is into the spinal cord system. Initial clinical manifestations are progressive and often misleading, with pseudoradicular pain of the lower extremities or intermittent claudication which was observed in both patients. Only good quality myelography enabled visualization of the dilated vein at the level of the conus medullaris which lead to localization of the arteriovenous malformation and its afferent arteries outside of the spinal cord itself. Treatment is either surgical, or neuroradiological (embolization). Similar results are obtained by both methods, in a condition which would otherwise progress to paraplegia.

Arteriovenous Malformations↗
PubMed1983

[Comparative double-blind study of ketoprofen slow-release tablets and indomethacin in coxarthrosis and gonarthrosis].

This comparative trial, in which each patient acts as his own control, is an ideal model for comparing the effectiveness of both products. None of the criteria studied demonstrated a statistically significant difference in effectiveness between the two agents. Under the conditions of this study, Bi-Profenid and indomethacin can therefore be considered as having comparable potency. Study of tolerance demonstrated a superiority of Bi-Profenid over indomethacin, with excellent results in 72.5% and 66.1% of cases respectively. Specifically, digestive and above all neuro-sensory tolerance was better with Bi-Profenid. Osteoarthritis is a good indication for these medications whose effectiveness is well documented.

Aged↗
PubMed1983

[Strict correlation between anti-RANA antibodies and anti-EBNA antibodies apart from rheumatoid arthritis. Assessment of the diagnostic value of anti-RANA antibody].

In order to study the relationship between anti-RANA antibodies (aRANA) and the antibodies capable of recognising other Epstein-Barr induced antigens, we examined the sera of 51 patients without rheumatoid arthritis for anti-RANA, anti-EA, anti-VCA, and anti-EBNA antibodies. These subjects were cases of Burkitt's lymphoma, infectious mononucleosis, naso-pharyngeal carcinoma, immune disorders, Hodgkin's disease and normal controls. A blind study was conducted in two separate laboratories. Anti-RANA was detected by indirect immunofluorescence on RAJI cells synchronised in phase G1. There was a very strict correlation between anti-RANA and anti-EBNA with no correlation between anti-RANA and anti-EA or anti-VCA. In another experiment, 15 coded sera from patients with classical rheumatoid arthritis were tested following adsorption of the rheumatoid factor. One serum was found to be devoid of both anti-RANA and anti-EBNA. These results demonstrate that anti-RANA is widely distributed outside of rheumatoid arthritis and they question the distinction between EBNA and RANA, as the antibody titres directed against these antigens are regularly linked together.

Antibodies↗
PubMed1983

[Bone and phosphoro-calcium metabolism in reflex sympathetic dystrophy].

A combined study organised by the French Society of Rheumatology was devoted to the investigation of bone and phosphoro-calcium metabolism in cases of reflex sympathetic dystrophy. The following observations were made: the usual phosphoro-calcium parameters are not altered, apart from a slight elevation of the urinary calcium in multifocal forms of the disease, during the 3rd and 4th months; the level of PTH, studied in 11 patients, was normal in each case; the examination of 8 bone biopsies, one performed in the 7th week and six others performed during the 3rd and 4th months of the disease, showed, initially, invasion of the spongy tissue by oedema, signs of marrow stress and bone stress, with a reduction in the number of osteoblasts, without any marked alteration of bone remodelling. At a later stage, the biopsy shows intense bone remodelling with hyperosteoclastosis and hyperosteoblastosis and the formation of irregular bone tissue which later becomes lamellar. Electron microscopic study of two biopsies revealed signs of acellular demineralisation with normal appearance of the osteoblasts and osteoclasts.

Bone and Bones↗
PubMed1981

[Bacterial spondylodiskitis. Diagnostic problems].

The authors carried out 193 needle aspiration of needle biopsies of the discs or vertebrae in 7 French Rheumatology Units to draw up the bacteriological diagnosis in infectious spondylodiscitis. The bacteria were identified in 62.7% of cases on average, the score of the most favourable series reaching 80%. No incident or accident was observed. These results, which are definitely better than direct surgical exposure, suggest the widespread adoption of this technique before any antibiotic therapy whenever spondylodiscitis is suspected. However, a prospective study with a uniform protocol seems necessary in order to draw up more precisely the value and limits of the method.

Bacterial Infections↗