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Biomedical subjects

J Grüntzig

Publications and source records attributed to J Grüntzig.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Hyalinosis cutis et mucosae (Urbach-Wiethe lipoidproteinosis)].

Hyalinosis cutis et mucosae is a rare, probably autosomal-recessively inherited disease, which begins in the first weeks of life with a remarkable hoarseness due to deposits of hyaline material in the larynx. Later on alterations of the mucous membranes and the skin are involved. Etiology and pathogenesis are unknown. An effective treatment does not exist. We present a Turkish family whose 4 children show the typical picture of hyalinosis cutis et mucosae. The skin alterations at the mother's eyelids, however, cannot be submitted to the lipoid proteinosis Urbach-Wiethe with certainty. The occurrence of hyalinosis cutis et mucosae in the 4 children makes the hitherto presumed autosomal-recessive heredity of the disease questionable.

Child↗
PubMed1983

[Lymphographic and morphological studies of the conjunctiva in onchocerciasis patients in Liberia].

Conjunctival lymphographies in patients infected with Onchocerca volvulus in Liberia showed normal or only slightly dilated lymphatics. The light-microscopical studies of conjunctival specimens revealed microfilariae predominantly in edematous dilated interstitial channels. Microfilariae in lymphatics and interstitial channels without endothelium of the conjunctivae were demonstrated by scanning and transmission electron microscopy. No signs of inflammatory cellular reaction were found in the vicinity of the parasites. In conclusion, the dilatation of lymphatics and interstitial channels as well as the pathways along which the microfilarial penetrated the cornea and the anterior segments of the eye are discussed.

Conjunctiva↗
PubMed1983

[Filariasis of the eye: problems with animal models].

Twelve rodents (Mastomys natalensis and Meriones persicus) were infected, with L3 larvae of Litomosoides carinii and Dipetalonema viteae. Eighty days after infection the number of microfilariae (L1 larvae) was determined by smears from the peripheral venous blood. It was found that there were 48 and 69 X 10(3) microfilariae per ml blood. The hosts were killed and the eyes (conjunctiva, cornea, uvea, posterior part of the globe, optic nerve) as well as other organs (skin, brain, liver, heart and skeletal muscles, kidney, diaphragm and lung) were embedded for electron microscopic studies. Eight of the infected rodents, which are the specific hosts for these filariae, had been treated before the dissection with metrifonate (3 X 100 mg/kg) or diethylcarbamazine (3 X 250 mg/kg). These dosages led to the disappearance of microfilariae from the peripheral venous blood. In untreated controls microfilariae were found in the vessels of the chorioidea and retina, whereas after therapy there was no trace of these larvae in the eye. However, in the capillaries and in the interstitial space of other organs numerous degenerating microfilariae were observed. Furthermore, some larvae were seen intracellularly in liver and muscles. These intracellular stages had fewer or even no lesions compared to the extracellular ones, suggesting that they might escape the activity of the drugs. It is unknown whether similar phenomena occur in worms pathogenic to man. These laboratory models using the filariae of rodents (D. viteae with unsheathed and L. carinii with sheathed microfilariae) are very helpful for studying the pathogenic effects in eyes caused by microfilariae which circulate in the blood stream (Loa, Wuchereria).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1982

[Indirect lymphography at the eye and in the face- and neck-region with iotasul (author's transl)].

For the first time the lymphatic pathways of the conjunctiva and the eyelids of dogs could be presented in vivo with the water-soluble X-ray contrast medium iotasul. By means of indirect application the lymph flow could be demonstrated up to the truncus jugularis. Because of the simultaneous infusion of the contrast medium at different points the lymphography of the face- and neck-region is considerably facilitated.

Animals↗
PubMed1981

[Ophthalmomyiasis].

We may distinguish an ophthalmomyiasis externa (fly larvae in the outer eye) and an ophthalmomyiasis interna (entry of fly larvae into the eye). While the first usually takes a mild course (conjunctivitis) the latter nearly always leads to loss of the sight. Besides three cases of O. externa the mechanical irritating effect of the larva Oestrus ovis Lin. (stage I) on the basis of scanning electron microscopic pictures is discussed.

Adult↗
PubMed1981

Electron microscopic studies on microfilariae of Dipetalonema viteae and Litomosoides carinii: the occurrence of intracellular parasites after treatment with metrifonate or diethylcarbamazine.

Microfilariae of Dipetalonema viteae and Litomosoides carinii were studied by means of electron microscopy after oral treatment of their hosts with metrifonate (3 x 100 mg/kg) or diethylcarbamazine (3 x 250 mg/kg). These dosages led to the disappearance of microfilariae from the peripheral venous blood. However, in numerous organs blood capillaries or interstitial spaces contained degenerating microfilariae. In these cases the cytoplasm of the microfilarian cells was completely lysed, whereas the cuticle seemed to be unaffected, at least initially. Microfilariae of both species were also often found intracellularly especially in liver and muscle cells after application of both drugs. The intracellular microfilariae, however, had fewer or even no lesions, suggesting that they might escape the activity of the drug.

Animals↗
PubMed1980

[Does dionine (aethylmorphin) influence the lymph drainage of the eye? (author's transl)].

Drainage of a lymphotropic solution of Tc-99m sulfur colloid from the vitreous body was studied in twelve rabbits. Shortly after the application of this tracer, six of these rabbits had an injection of 0.06 ml, 0.5% dionine (Aethylmorphin) solution into the retrobulbar space. After the dionine injection, the decay of radio-activity from the eyes was significantly increased. The radio-activity in the control group approximated to 81.6% of the total applied radio-activity after six hours, whereas the radio-activity in the eyes of the dionine treated group was, on average, only 5% after the same time interval. Simultaneously, the radio-activity in the cervical lymph nodes increased significantly from approximately 0.10% in the control group to 0.67% in the dionine treated group. It is not known, as yet, whether dionine increases lymph drainage in man.

Animals↗
PubMed1980

[Ectopic lacrimal gland under the bulbar conjunctiva].

In a 20-year-old female patient a small tumor (3 mm in diameter) was found in the upper nasal quadrant of the left conjunctiva bulbi. Lymphangiography showed that the conjunctival lymph vessels were ectatic. The histological study identified the excised material as tissue of the lacrimal gland.

Adult↗
PubMed1979

[Cameroon swelling; infection by the filaria Loa loa].

Recurrent skin edemata due to an infestation with the filaria Loa loa are called Cameroon or Calabar swellings. These are tense elastic, circumscribed, indolent swellings, which are just slightly red coloured and disappear within 24 to 48 hours. Intervals of several weeks or months may occur. One should think of Loa loa disease seeing travellers return from Loa endemic areas (West Africa) with recurrent, transitory edema and eosinophilia. The stay in these areas may have been several years before! Treatment and prophylaxis: Diethylcarbamazine.

Cameroon↗
PubMed1979

[Xerophthalmia].

Xerophthalmia results from an insufficient supply of vitamin A to the eye. Primary signs of xerophthalmia are conjunctival xerosis, Bitôt's spots with conjunctival xerosis, corneal xerosis, corneal ulceration with xerosis, keratomalacia. Secondary signs of xerophthalmia are night blindness, xerophthalmia fundus and corneal scars. According to the WHO 20 000--100 000 children in developing countries are struck annually with blindness due to xerophthalmia. With regard to the treatment immediate therapy with 100 000 I.U. vitamin A intramuscularly and 200 000 I.U. orally on the following day are advised in all cases of active disease. The doses should be reduced by half for children less than one year old. Prior to discharge from the clinic and additional dose of 200 000 I.U. vitamin A (children under the age of one year 100 000 I.U.) orally should be administered.

Administration, Oral↗