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Biomedical subjects

J Graff

Publications and source records attributed to J Graff.

82 records · Page 5Linked to original sources
PubMed1984

[Stress studies with dipyridamole in patients with coronary heart disease in comparison to coronary angiography, myocardial scintigraphy and ergometry findings].

In 102 patients with typical symptoms of angina pectoris who underwent a coronary angiography a Dipyridamol test was performed. The result was a sensitivity of about 84% concerning the coronary heart disease and a specifity of about 93%. In the same test persons the ECG after work showed a sensitivity of about 84% and a specifity of about 57%. Dipyridamol test and bicycle ergometry are methods of the same value for the preinvasive diagnostics of the coronary heart disease which should supplement each other. The higher specifity of the ECG changes in the Dipyridamol test was evident in comparison to the bicycle ergometry. In 85 of our patients the Tl-201-scintigraphy was carried out under Dipyridamol and ergometer stress. For the Tl-201-scintigraphy under Dipyridamol a sensitivity of about 70% and a specifity of about 81,5% was the result. In the Tl-201-scintigraphy under ergometer load a sensitity ob about 84% and a specifity of about 57% was the result. The proportion of exactly positive findings increased with the number of the stenosed vessels under ergometer as well as Dipyridamol intervention. A negative load scintigraphy does not exclude a coronary heart disease, but renders a three-vessel-disease very improbable.

Angina Pectoris↗
PubMed1981

Broad specificity hexose transport system with differential mobility of loaded and empty carrier, but directional symmetry, is common property of mammalian cell lines.

Rapid kinetic techniques were employed to measure the transport of the nonmetabolizable hexose, 3-O-methyl-D-glucose, in suspensions of human HeLa cells, mouse L- and P388 leukemia cells, and Chinese hamster ovary cells in zero-trans entry and exit and equilibrium exchange procedures. The kinetic parameters of transport were computed by fitting appropriate integrated rate equations to time courses of transmembrane equilibration of radiolabeled substrate. Transport of all four lines, as in Novikoff rat hepatoma cells, conformed to a simple carrier model with directional symmetry but differential mobility of loaded and empty carrier. As was apparent from a comparison of influx and exchange flux, the loaded carrier of all cell types moved between 4 and 14 times faster than the empty carrier. ATP depletion of the cells by incubation in glucose-free medium containing KCN and iodoacetate had no significant effect on the kinetic properties of the transporter. ATP-depleted cells were used to measure the transport of D-glucose, 2-deoxyglucose, D-galactose, and D-glucosamine in the absence of intracellular metabolism. The differential mobilities of empty carrier and carrier loaded with these hexoses and the efficiency of their transport were equivalent to those observed with 3-O-methylglucose, but the Michaelis-Menten constants for the transport of D-galactose and D-glucosamine were 5-8-fold higher than those for D-glucose, 2-deoxy-D-glucose, and 3-O-methylglucose, which were about equivalent.

Animals↗
PubMed1980

Melanosis of the gall bladder.

A case of melanosis of the gall bladder is described. Ultrastructural examination confirms that the pigment is related to lipofuscin.

Aged↗
PubMed1979

[Double urologic tumors: reduced immunocompetence?].

55 patients with primary multiple neoplasias underwent immunostaging with determination of the immunoglobulins, B- and T-lymphocyte counting, H3-lymphocyte stimulation (ConA, PWM, PHA) and DNCB-epidermal test. There were no significant differences between the PMN-group and a group of patients with solitary tumors, whereas both cancer patient groups revealed a diminished immunocompetence compared with a non-malignant control group of patients.

Adult↗
PubMedDate not supplied

Prostacyclin and iloprost: equal efficiency in preserving high energy phosphates in the dog heart following coronary artery ligation.

The influence of PGI2 and iloprost on the contents of high energy phosphates, cAMP, glycolytic metabolites and on cardiac performance was investigated in open-chest dogs subjected to 3 h of ischaemia, induced by occlusion of the left anterior descending coronary artery. The administration of drugs for 2 h, starting 1 h after the onset of ischaemia, resulted in a normalization and an appreciable reduction in the loss of high energy phosphates in the non-ischaemic and ischaemic left ventricular muscle, respectively, leading to an improvement in the phosphate potential of the cardiac tissue. A reduction in the ischemia-induced rise in cAMP levels was observed, indicating a lower catecholamine overflow in the presence of these drugs. PGI2 and iloprost in the dose employed significantly decreased cardiac preload, which was found to be elevated in the untreated animals after coronary artery ligation. The observed effect of PGI2 and its mimetic on the haemodynamics, as well as on myocardial cAMP and high energy phosphate levels of the heart, may be considered helpful in the phase of temporary imbalance between energy demand and supply during acute ischaemia.

Adenosine Triphosphate↗
PubMedDate not supplied

Knotting and entanglement of multiple central venous catheters.

A 53-yr-old black male was admitted with peripheral vascular disease and septic shock. Appropriate cardiopulmonary resuscitation and operative intervention required the placement of multiple central venous lines. These included two subclavicular central venous pressure (CVP) catheters and one Swan-Ganz catheter (SGC). During manipulation of the SGC, it formed a knot with the two CVP catheters entangled in it. After consideration of the variety of strategies that could be employed, the CVP catheters were manually disengaged from the knot and the knot was surgically removed. The increasing frequency and multiple central angioaccess catheters will result in a finite increase in the nature and complexity of the clinical challenges. The insistence on the use of multiple single-channel catheters for separate therapeutic functions and the duration of stay of pulmonary catheters should be reconsidered.

Cardiac Catheterization↗
PubMedDate not supplied

Parameter estimation in six numeric models of transperitoneal transport of glucose.

Six competing kinetic models of transperitoneal glucose transport were formulated and validated. The models were designed to elucidate the presence or absence of diffusive, nonlymphatic convective and lymphatic convective solute transport. The validation procedure included an assessment of theoretical and practical identifiability, goodness of fit, residual error analysis, and plausibility of parameter estimates. Experimental results were obtained from 21 patients without diabetes. The validation procedure demonstrated that the model that only included diffusion was superior to the other models. Theoretically, both nonlymphatic convective and lymphatic convective transports might exist. However, neither the ultrafiltration sieving coefficient nor the lymphatic flow rate were practically identifiable, probably because any amount of glucose transported by nonlymphatic convective and lymphatic convective transport mechanisms was negligible compared with the amount transported by diffusion. Based on these results, there appear to be problems measuring convective solute transport parameters when the solute transport is in the dialysate-to-blood direction while the fluid transport is in the blood-to-dialysate direction.

Adult↗