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Biomedical subjects

J Greene

Publications and source records attributed to J Greene.

At least 505 records · Page 28Linked to original sources
PubMed1992

The binding specificity of normal and variant rat Kupffer cell (lectin) receptors expressed in COS cells.

A receptor uniquely found on the surface of rat Kupffer cells was shown previously to bind oligosaccharides terminating in galactose, N-acetylgalactosamine, and fucose. To analyze further the binding specificity of the receptor, receptor-mediated adhesion of transfected COS cells to immobilized glycolipids of known structure was measured. The glycolipid Gb4Cer (GalNAc beta 1-3Gal alpha 1-4Gal beta 1-4Glc beta 1Cer) was the best ligand. Gb5Cer (GalNAc alpha 1-3GalNAc beta 1-3Gal alpha 1-4Gal beta 1-4Glc beta 1Cer) and LacCer (Gal beta 1-4Glc beta 1Cer) bound more weakly (five times less than Gb4Cer) and Gb3Cer (Gal alpha 1-4Gal beta 1-4Glc beta 1Cer), and g3Cer(GalNAc beta 1-4Gal beta 1-4Glc beta 1Cer) bound even more weakly (60 times less than Gb4Cer). Gangliosides did not support adhesion of transfected cells. The adhesion of COS cells transfected with plasmids encoding variants of the receptor was also examined. In each variant, either tryptophan 498 or 523, which are conserved in most C-type lectins, was replaced by one of several amino acids. Variants that retained binding activity had the same specificity as the normal receptor. Differences between variants were noted, however, in maximal levels of adhesion and these differences correlated with altered expression of the receptor variants in COS cells.

Acetylgalactosamine↗
PubMed1992

Hospitals struggle with the changing of the guard.

Not many chief executive officers want to think about the need to plan for the time when they're gone; even fewer do it. Even so, succession planning traditionally has been one of the CEO's main responsibilities to ensure the organization's long-term viability. However, some experts predict that only 10% of healthcare organizations have written down their succession plans.

Chief Executive Officers, Hospital↗
PubMed1992

CHC seeing fruits of efforts to improve communications.

Since its formation in 1980, the Catholic Health Corp. occasionally has grappled with conflict between central authority and individual hospital autonomy, often a result of fundamental communication problems. In response, the management company has begun a systemwide program aimed at simplifying the complex governance process and smoothing relationships between boards.

Catholicism↗