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Biomedical subjects

J Grenet

Publications and source records attributed to J Grenet.

8 recordsLinked to original sources
PubMed1992

Effect of caffeine and isobutyl-methyl-xanthine on production of binucleate cells and on post-replicative repair.

Caffeine (CAF) but not 3-isobutyl 1-methyl-xanthine (IBMX) displayed a strong DNA anti-repair effect in G2 prophase, as estimated by the frequency of abnormal chromosomes in anaphase-telophase found shortly after treatment. IBMX is more effective than CAF in inhibiting cytokinesis, while the binucleate cells formed by a short treatment with any of these two xanthines have similar cycle kinetics.

1-Methyl-3-isobutylxanthine↗
PubMed1991

Beta 1-4-galactosyltransferase gene expression is regulated during entry into the cell cycle and during the cell cycle.

Mammalian glycosyltransferases have been implicated in a wide variety of functions besides N-linked glycosylation, including developmental processes. For this reason, we studied the effects of cell cycle and entry into the cell cycle on beta 1-4-galactosyltransferase gene expression. In this study we report that beta 1-4-galactosyltransferase (GalTase) gene expression is, indeed, regulated during the normal cell cycle, peaking during late G1-, S, and early G2 phase of the cell cycle. In addition, GalTase gene expression is regulated in a manner that resembles other "early response" genes such as jun and fos upon reentry into the cell cycle from quiescence. Finally, we show that the GalTase gene is differentially expressed during murine embryogenesis and in terminally differentiated adult tissues. It is most abundant in testis, followed by skeletal muscle and spleen. The reasons for this pattern of differential expression in adult tissues are unknown. These studies should provide important new information regarding GalTase gene expression, its regulation, and its potential link to other developmental functions.

Animals↗
PubMed1986

[Controlled fistula of Wirsung's duct].

In order to prevent the serious pancreatic fistulae which complicate anastomoses between the pancreatic tail and a jejunal loop after cephalic duodenopancreatectomy, we propose a pancreatic fluid derivation on a temporary drain equivalent to a controlled fistula of Wirsung's duct. This already known technique consists of a punctiform anastomosis on an Escat's supporting drain between the main pancreatic duct and the jejunum. No complication occurs when the drain is removed 12 days later, as shown by a series of 24 cephalic duodeno-pancreatectomies where this technique was used.

Drainage↗
PubMed1985

[Temporary jejunostomy].

The different techniques used for temporary jejunostomy are described. They are governed by the presence or absence of utilizable stomach. The advantages and drawbacks of each technique are examined. The simplest and most reliable one is transgastric jejunostomy. Two variants of jejunostomy after total gastrectomy and oesophagectomy are described.

Enteral Nutrition↗