Biomedical subjects
J Grohsman
Publications and source records attributed to J Grohsman.
Discussion paper: dual effects of tumor antigens: induction of tumor resistance or tumor growth enhancement.
TA3-HA nonspecific tumors growing in ascites form shed their membrane components into the ascites fluid. This product can induce tumor growth enhancement if given together with or after i.p. tumor inoculation in relatively large quantities, but if given i.m. in small quantities, several days before tumor challenge, the mice show an elevated resistance to the tumor. The strictly strain-specific TA3-St line does not release such membrane components into the ascites fluid. It has also been found that the TA3-HA cells have a larger membrane fluidity than the TA3-St cells, as measured by membrane microviscosity, using the Shinitzki procedure. Isolation and gross chemical analysis of the TA3-Ha ascites fluid component was carried out. Results, so far, indicate that the active site of this product is probably carbohydrate in nature. The possible mode of action of such component in tumor growth enhancement is most probably by overwhelming and neutralizing immunocytes capable of recognition and eventually cytotoxic action.
Escape of TA3 tumors from allogeneic immune rejection: theory and experiments.
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Mixed tumor challenge of strain specific and nonspecific TA3 mouse ascites mammary adenocarcinoma.
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The immune recognition of TA3 tumors, its facilitation by endotoxin, and abrogation by ascites fluid.
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