Concentrations of putrescine, spermidine and spermine were determined in biopsies of skin of eight control subjects and of uninvolved skin and skin lesions of eight psoriatic patients before and after topical therapy with dithranol. Mean spermidine and spermine concentrations in uninvolved skin of psoriatic patients were normal, but putrescine concentration was elevated. In psoriatic skin lesions all three amines were significantly elevated. Chemotherapy effectively reduced polyamine concentrations in involved skin touards normal. This decrease in polyamine levels correlated with reduction of the proliferative activity of the epidermis and with clinical improvement of the patients.

Adolescent↗

PubMed1978

Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity.

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Animals↗

PubMed1978

Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice.

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Adenosylmethionine Decarboxylase↗

PubMed1977

Tumor blush with intracranial extensions of carcinoma of the paranasal sinuses.

Two malignant intracranial tumors that originated in the paranasal sinuses are described. The patients in both cases were investigated for neurological disorders and had no relevant history of sinus disease. Cerebral angiography demonstrated tumor vascularity identical to meningioma.

Brain Neoplasms↗

PubMed1977

Gas-liquid chromatography of methylpentynol carbamate and its metabolite 3-methylpentyne-3,4-diol.

Procedures are described for the determination of methylpentynol carbamate in serum, either by injection into the chromatograph of diluted serum or extraction of the drug into chloroform and injection of an aliquot of the concentrated organic phase; a 4% CDMS column is used. Similar assays for measuring the metabolite 3-methylpentyne-3,4-diol in urine are reported. The methods have been used for measuring methylpentynol carbamate and its metabolite in samples from rats and dogs.

Alkynes↗

PubMed1975

Kinetics of salicylate metabolism.

1 Nine patients with rheumatoid arthritis or non-inflammatory backache were given soluble aspirin (65 mg/kg body weight) daily. There was no significant difference between the plasma salicylate of those with rheumatoid arthritis and those with backache. 2 Two patients had plasma salicylate values that differed significantly from the remainder but neither these results nor the marginal differences between plasma salicylate levels of the others could be explained by individual variations in the capacity for excreting salicyluric acid or salicyl phenolic glucuronide. 3 Increasing the dose of aspirin in four patients demonstrated the reduced proportions of salicyluric acid and salicyl phenolic glucuronide excreted at high doses and the increased importance of unchanged salicylic acid as an excretory pathway. These findings are consistent with a limiting capacity for salicyluric acid and salicyl phenolic glucuronide synthesis and excretion. 4 The findings in one patient suggested that inter-subject variations in the capacity for producing salicyl phenolic glucuronide and salicyluric acid may have an effect on plasma salicylate levels at high doses of aspirin.

Arthritis, Rheumatoid↗