Biomedical subjects

J Grunst

Publications and source records attributed to J Grunst.

At least 37 records · Page 2Linked to original sources

PubMed1975

[Variations of human serum alpha-fetoprotein concentration after partial hepatectomy (author's transl)].

Alpha-fetoprotein serum concentrations were determined by radioimmunoassay in 5 patients with echinococcus involvement of the liver. In 4 cases a partial hepatectomy was possible, whereas in 1 case laparotomy had to be confined to an exposure of the liver hilus because of too many dispersed echinococcus cysts. All patients showed normal AFP levels below 20ng/ml before operation. Within the first to third postoperative day maximal AFP increases of AFP level between 2760 and 5600 ng/ml developed, which returned to normal during the following days and weeks. One patient who was submitted to strumectomy and to the same anaesthetic liver charge had no change in her normal AFP concentration. The postoperative changes of AFP level observed are interpreted as an expression of a quick and intense liver cell regeneration following the surgical treatment.

Adult↗

PubMed1975

Suitability of non-glucose-carbohydrates for parenteral nutrition.

Postoperative parenteral nutrition can only be optimally effective if the characteristics of post-traumatic metabolism are taken into account. Two main possibilities are discussed for the carbohydrate component of parenteral nutrition during this phase: glucose with high doses of insulin or non-glucose carbohydrates (sugar substitutes) possibly in a suitable combination with glucose. The risks as well as the technical and organisational problems involved in the use of them are discussed and the authors prefer the second of the two alternatives. Possible side effects of non-glucose carbohydrates are pointed out and it is shown how these can be avoided by observing dose guidelines. So far a combination of frucose : glucose : xylitol in a ratio of 2 : 1 :1 with a total dose of 0.50 g/kg/hour has been studied most thoroughly. This combination normalises the fat metabolism and improves glucose tolerance without requiring exogenous insulin. Experiences with this combination as well as individual non-glucose carbohydrates on operated patients have been given continuously for up to 7 days and in some cases even for several weeks. No side effects, no deviations from a steady state and no abnormal changes of the laboratory values occurred. The authors are of the opinion that non glucose carbohydrates are necessary if the facilities for frequent blood sugar controls are not available.

Adenine Nucleotides↗

PubMed1975

[Oxygen, carbohydrate and fat metabolism of the splanchnic region under the influence of equimolecular parenteral doses of glucose and fructose].

Hepatic metabolic balances derived from arterio-hepatic venous substrate differences and hepatic blood flow exhibited similar results during fructose and glucose infusion (10 g/5 min, 0.5 g/kg X h) as compared to those from the isolated perfused organ. Accordingly, in account of hepatic utilization of fructose glucose homeostasis and secretion maintained during fructose infusion. However, the smaller insulin response during fructose infusion did not reduce hepatic free fatty acid utilization to such an extend as to increase pyruvate oxydation. Thus, splanchnic production of lactate and pyruvate descending from fructose was enhanced leading to a 7-fold increase of arterial lactate concentration. Since hepatic venous lactate to pyruvate substrate ratios did not change, the rise of the arterial redox couple could not be due to hepatic fructose metabolism. According to the findings from the isolated perfused organ, fructose seemed to be phosphorylated at a rate which was found to be 2-3-fold that of glucose as calculated from splanchnic utilization rates. The rapid ATP-breakdown was followed by an increment in splanchnic oxygen consumption. The larger energy demand during fructose infusion seemed to be satisfied by an enhanced endoxydation of free fatty acids.

Adenosine Triphosphate↗

PubMed1975

[Influence of parenteral fructose or glucose administration on uric acid formation and phosphate uptake of the human liver].

15 min. after intravenous administration of fructose (10 g/5 min, 0,5 g/kg/h) the hepatic uric acid production in healthy volunteers increased from 0,07 mg/100 g X min to 0,52 mg/100 g X min. After one hour the enhanced uric acid production was 0,3 mg 100 g X min. The enhanced uric acid production was accompanied by an increased hepatic phosphate uptake. The highest value was 13 mumol/100 g X min. During the control period the liver released small amounts of phosphate into the hepatic vein. The increased hepatic uric acid output correlated with an enhanced renal clearance, therefore the peripheral venous uric acid concentrations remained unchanged.

Fructose↗

PubMed1975