Biomedical subjects
Publications and source records attributed to J Guérin.
The authors studied the standard values for plasma oncotic pressure in 216 blood donors. They compared the oncotic pressure in terms of sex and whether a serum or plasma sample was used. They also studied the stability of the oncotic pressure over a 24 hour period.
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A statistical study was used to determine the significant prognostic factors in a protocol containing surgery, radiotherapy and polychemotherapy applied to 121 consecutive unselected patients suffering from malignant gliomas. The histological grade of the malignant tumor, the age of the patient and the neurological state if it could be evaluated after surgery appeared to be significant. It is therefore possible to suggest a clinical classification into three groups. Group 1 consists of patients aged 50 or less and a postoperative neurological state of 1 or 2 according to Order's classification; group 2 consists of patients with one pejorative factor, i.e. aged over 50 or a postoperative neurological state of 3 or 4; group 3 is those patients with two pejorative factors (aged over 50 and postoperative neurological state of 3 or 4) or aged 65 or over. Methods of application of treatment are also involved in the therapeutic response: Excision surgery appears to be essential. It improves the duration and quality of survival and influences the efficacy of combined radio-chemotherapy. By contrast, the effects of cobalt and chemotherapy must be envisaged in an efficacy/tolerance ratio which is difficult to evaluate, but for which the suggested clinical classification as a certain indicative value. Finally, the various factors lead to an approach to the concept of therapeutic responses and to determine within the total population of malignant gliomas various categories of patients in whom the profile is defined both by clinical characteristics and the tolerance of treatment and in whom different treatment techniques must be envisaged.
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The study of the chemical composition and of the electrophoretograms of 21 different human whole casein samples confirms the presence of an important heterogeneity between the different samples. A very considerable variability of phosphorus and sugars contents and a correlation between the different sugars components of the casein have been demonstrated statistically. The study of 3 milk samples from the same woman showed a decrease of the amino-sugars of the casein after the birth.
The electrocardiogram (E.C.G.) was recorded in 100 cases of meningeal hemorrhages. The most frequent abnormalies encountered were bradycardia (32%) and inversion of the T wave (34%). Rhythm and conduction problems were less frequently found. Bradycardia was frequently and T wave inversion rarely found in cases without disturbances of consciousness and those with favourable prognosis. The contrary was found in comatous patients and cases with lethal outcome. The existance of an aneurysm and the location of it did not influence the type of electrocardiographic abnormalies. The influence of the parasympathetic and especially the sympathetic nervous systems is emphasized.
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PURPOSE: Retrospective analysis of 17 patients with intracranial germ cell tumors treated in a multidisciplinary consultation at the Bordeaux University Hospital a and literature review. MATERIALS AND METHODS: Seventeen consecutive patients were treated from 1978 to 1995 for a primary intracranial germ cell tumor. Median age was 14 (range 3-29 years). There were two malignant teratoma, six proved germinoma and nine presumed germinoma (diagnostic based on biological, radiological and treatment criteria). All received radiotherapy from 30 to 60 Gy (median 40 Gy) in different volumes. Chemotherapy was administered in 15 cases, three after surgery and 12 after radiotherapy. RESULTS: All tumours were in complete remission after initial treatment. The two malignant teratomas recurred in non-irradiated area after nine and 48 months, and the patients died. None of the germinoma recurred within a follow-up period of two to 17 years (median 65 months). Five and 10 year actuarial overall survival rates were the same: 84% for all histologies and 100% for germinomas. Only two patients developed school difficulties and six presented an hypopituitarism, of which one was consecutive to radiotherapy. Chemotherapy was well tolerated. CONCLUSION: This retrospective study and literature analysis are in favor of limited dose and volume of radiation therapy associated with chemotherapy.