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Biomedical subjects

J Guihard

Publications and source records attributed to J Guihard.

16 recordsLinked to original sources
PubMed1990

[Treatment of vomiting in infants and children induced by acute infectious pathology. A comparative study of alizapride versus metopimazine].

The effectiveness and tolerance of alizapride and metopimazine used to treat vomiting induced by acute infectious diseases were evaluated in 47 infants and children seen in five hospitals. Patients were randomized to alizapride (n = 23) or metopimazine (n = 24). Medications were given orally (drops) for 3 to 5 days. All the patients were monitored until the end of the study period. Effectiveness was excellent or good in both groups with no statistically significant difference. Clinical tolerance was outstanding in both groups; one patient in the alizapride group exhibited transient, mild drowsiness after the doses. This study confirms the good risk/benefit ratio of alizapride in the treatment of emesis in infants and children.

Antiemetics↗
PubMed1989

[A relapse in the eye of acute lymphoblastic leukemia].

Two months after discontinuation of maintenance chemotherapy for acute lymphoblastic leukemia, an eight-year old boy developed anterior uveitis shown by aspiration of the anterior chamber to be caused by a recurrence. At the initial stage of ocular involvement, no evidence of neuromeningeal involvement was present. Remission was achieved by topical corticosteroid therapy, systemic chemotherapy, and irradiation of the eyeballs. The patient then underwent total body irradiation, major chemotherapy, and autogenic bone marrow transplantation. The fact that the eye acts as a "sanctuary" explains why delayed ocular recurrences are occasionally seen in acute lymphoblastic leukemia.

Anterior Chamber↗
PubMed1988

Efficacy of low-dose Aracytine in 3 cases of refractory anemia in transformation in children.

A treatment with cytosine arabinoside in low doses is administered to 3 children affected by refractory anemia with myeloblast in transformation. The remission is obtained in 3 cases. One child relapsed at 24 months. The other 2 children are in persistent remission at 40 and 48 months. This relatively non-aggressive mode of treatment seems to have a place in children affected by myelodysplasia and for whom allografting from an HLA-identical donor is not available.

Anemia, Refractory↗
PubMed1984

[Dorsal extradural hourglass lipoma in children].

The authors would like to recount and discuss the case of a 14 months old child which presented a dumbbell dorsal lipoma, purely extradural with no congenital anomalies. The warning signal was the discovery of paraparesis with the regression of walking ability. The hypothesis of medullary compression by a dumbbell dorsal tumor was quickly dismissed with the discovery of a mediastinal mass on the pulmonary X-Ray. A diagnosis of the pre-operational neuroblastoma was carried out because of detection of dorsal epidural medullary compression revealed by the myelography. The testing was completed with a vertebral computed tomography, which clearly showed the extent of medullar compression, and the mediastinal tumoral development under the paravertebral muscular masses. The child was operated on at 2 fronts, vertebrally and thoraxically for an encapsulated, perfectly separable and non hemorrhaging tumor. The anatomopathological examination confirmed the diagnosis of the lipoma. It is in the resumption of the computed tomographic examination that the tumoral density measures will confirm fatty tissue with numbers of density--50. In light of the literature, we are discussing the appearance of the lipoma, entirely exceptional because of its dorsal location, its extradural and certainly its dumbbell position, with large thoraxic development. It is necessary to stress the importance of the meticulous neurological examination of the child, the diagnostical necessity of the CT scan and the importance of the avoidance of the creation of an instable vertebral lesion at the time of laminotomy. In this case only the early double surgical operation permitted the recovery of the child.

Epidural Space↗
PubMed1983

[Contribution of direct immunofluorescence diagnosis to the epidemiology of acute viral respiratory infections in young children].

Rapid diagnosis by immunofluorescence (IF) has enabled us to study the epidemiology of acute viral respiratory diseases in infants admitted to the CHRU at Caen between January 1980 and December 1982. 809 nasal aspiration samples were examined. Respiratory Syncytial Virus (RSV) was recovered in 36% of cases. These were observed during the four winter outbreaks which occurred during the study period and were extensive in 1980-1981 and 1982-1983. A virus was demonstrated in 13.5% of the 515 RSV negative specimens: 25 Rhinovirus, 21 Myxovirus parainfluenzae 3, 19 Adenovirus, 3 Myxovirus influenzae A, 2 Myxovirus influenzae B. RSV is the predominant pathogen as it is the most frequent and is responsible for more severe forms. However, epidemics vary from year to year and from one town to another. Rhinovirus, Myxovirus parainfluenzae 3 and Adenovirus infections are less frequent. Rhinovirus infections occur throughout the year and are certainly underestimated as isolation of the virus is difficult. Most Myxovirus parainfluenzae 3 cases occur in winter, and IF largely facilitates their diagnosis. Adenovirus infections are endemic and serotype 7 is frequent.

Acute Disease↗
PubMed1980

[Outbreak of hand, foot and mouth disease in a day-nursery. A new clinical form? (author's transl)].

Ten cases of vesicular eruption affecting primarily the hands (4/10) and feet (6/10) occurred in a day-nursery for infants. An enterovirus related to coxsackie A 16 virus was isolated from two vesicular fluids and nine stools. The fact that the outbreak took place in the winter, the rarity of pharyngeal lesions (2/10), the high incidence of foot lesions and the presence of listlessness as only associated symptom lead to a discussion of the relationship between this small epidemic and true hand, foot and mouth disease.

Child, Preschool↗