PubMed Health⌕ Search

Biomedical subjects

J Guimón

Publications and source records attributed to J Guimón.

34 records · Page 2Linked to original sources
PubMed1995

Schizophrenia: gender, family risk, and plasma homovanillic acid.

Plasma homovanillic acid concentration was assessed in 60 young schizophrenic patients, with and without first-degree relatives with schizophrenia, before treatment, and 3 days after starting haloperidol treatment. The baseline concentration of homovanillic acid in plasma was no different in the two groups before treatment; it was, however, significantly higher in the patients with relatives than in those without relatives diagnosed of schizophrenia after 3 days of haloperidol treatment.

Adolescent↗
PubMed1995

The use of group programs to improve medication compliance in patients with chronic diseases.

Non-compliance with medication is one of the major factors in the failure of therapeutic programs for patients having a chronic disease. The good results of a controlled study on the evolution of schizophrenic patients, who participated in a medication group program aimed at diminishing affective components of negative attitudes towards neuroleptics, are discussed. The building up of specific questionnaires could help in understanding the nature of the prejudices towards the use of medication in patients with chronic diseases. The organization of group programs could diminish patients' prejudices, thus improving compliance.

Attitude to Health↗
PubMed1995

[Identity crisis and training of psychiatrists].

A trend towards remedicalization in Psychiatry has become apparent in the 80's and 90's. Most psychiatrists tend however to maintain an eclectic attitude, although a few manifest a clear identity crisis leading sometimes to an hyperidentification with one of the psychiatric theoretical models. The training programs for psychiatric residents should take into consideration two important factors in the building up of the professional identity of the future psychiatrists: the tendency of the residents to identify with the ideology of their teachers and the modelling effect of the different types of clinical activities on the theoretical approach of the clinician.

Curriculum↗
PubMed1990

Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression. Effect of long-term cyclic antidepressant drug treatment.

The functional status of platelet alpha 2-adrenoceptors in patients with major depression has been assessed by simultaneously measuring both a biochemical mechanism of transduction of receptor activation (inhibition of adenylate cyclase activity) and a physiologic response of the receptor (induction of aggregation). The inhibitory effects induced by epinephrine and UK 14304 on adenylate cyclase activity were unchanged, while the aggregation responses induced by the same alpha 2-adrenoceptor agonists were potentiated, which indicated receptor supersensitivity. In depressed (n = 30) and euthymic (n = 11) patients as well as in control subjects (n = 66), there was a clear dissociation between inhibition of adenylate cyclase activity and induction of aggregation, indicating that the two responses represent different phenomena of alpha 2-adrenoceptor activation. alpha 2-Adrenoceptor-mediated platelet aggregation could represent a better marker than inhibition of adenylate cyclase to assess functional changes of the receptor in depression. Both of these functional responses are desensitized after long-term antidepressant treatment.

Adenylyl Cyclase Inhibitors↗
PubMed1986

Biochemical and functional evidence of supersensitive platelet alpha 2-adrenoceptors in major affective disorder. Effect of long-term lithium carbonate treatment.

The hypothesis that depressive illness is related to supersensitive alpha 2-adrenoceptors in the brain has been tested indirectly in blood platelets. The binding of tritiated clonidine hydrochloride to platelet membranes, a ligand that labels only the high-affinity state of the alpha 2-adrenoceptor that is coupled with cell functions, and the aggregation response induced by epinephrine hydrochloride, which is the result of the activation of the high-affinity state, were measured and correlated in 13 patients with major affective disorder. Both the number of high-affinity binding sites and the aggregation response were increased in depressed patients. There was a negative and significant correlation between both measures in the same depressed patients. Treatment with lithium carbonate (Plenur [Spain]; Linthane, comparable US product) was associated with a decrease in the high-affinity state and with an increase in the aggregation response. Thus, major effective disorder may be related to a dysfunction of the high-affinity state of the alpha 2-adrenoceptor that recognizes agonists and mediates physiological effects.

Adult↗