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Biomedical subjects

J Guindo

Publications and source records attributed to J Guindo.

At least 37 records · Page 2Linked to original sources
PubMed1993

Ventricular arrhythmias in left ventricular hypertrophy and heart failure.

The significance of ventricular hypertrophy in the genesis of ventricular tachyarrhythmias cannot be over-emphasized. Left ventricular hypertrophy, as a consequence of arterial hypertension, influences the three factors involved in the prognosis and we express these as a triangle of risk: electrical instability, left ventricular dysfunction and ischaemia.

Death, Sudden, Cardiac↗
PubMed1992

Coronary artery spasm and acute myocardial infarction in naproxen-associated anaphylactic reaction.

We present the case of a 43-year-old man who suffered an acute myocardial infarction after oral administration of 250 mg of naproxen, prescribed as antiinflammatory-analgesic agent after tooth extraction. Both intradermal skin test and human basophil degranulation test were positive to naproxen. These findings suggest a naproxen-associated anaphylactic reaction with concomitant coronary artery spasm and posteroinferior infarction, a clinical event previously not reported with the use of this drug.

Adult↗
PubMed1991

Active vs passive rhythms as an explanation of bigeminal rhythm with similar P waves.

We describe the criteria for differential diagnosis between 3:2 sinoatrial block from atrial bigeminy due to an ectopic focus in the sinus or parasinus zone. In the 3:2 sinoatrial block the RR interval of the basic rhythm is similar to the short R-R interval of the paired rhythm. In atrial bigeminy, the R-R interval of the basic rhythm is similar to the long R-R interval of the paired rhythm.

Atrioventricular Node↗
PubMed1990

Recasting the approach to the treatment of potentially malignant ventricular arrhythmias after the CAST study.

The best therapeutic approach to the therapy of potentially malignant ventricular arrhythmias is still unknown, particularly in view of the increased mortality with flecainide and encainide shown in the CAST study. Various ongoing studies, particularly with amiodarone, will show whether better results can be obtained with other agents. Flecainide and encainide do, however, have a restricted place when other agents cannot be used. Low-dose amiodarone with low-dose flecainide may be worth trying.

Anilides↗
PubMed1990

Recurrent pericarditis. Relief with colchicine.

Recurrence is one of the major complications of pericarditis. Treatment of recurrence is often difficult, and immunosuppressive drugs or surgery may be necessary. We conducted an open-label prospective study of nine patients (seven men and two women; age, 18-64 years; mean age, 41.7 +/- 13.7 years). Patients were treated with colchicine (1 mg/day) to prevent recurrences. All patients had suffered at least three relapses despite treatment with acetylsalicylic acid, indomethacin, prednisone, or a combination. Pericarditis was classified as idiopathic in five patients, postpericardiotomy in two, post-myocardial infarction in one, and associated with disseminated lupus erythematosus in one. For statistical analysis, we conducted a paired comparison design (Student's t test). All patients treated with colchicine responded favorably to therapy. Prednisone was discontinued in all patients after 2-6 weeks (mean, 26.33 +/- 10.9 days), and colchicine alone was continued. After a mean follow-up of 24.3 months (minimum, 10 months; maximum, 54 months), no recurrences were observed in any patient; there was a significant difference between the symptom-free periods before and after treatment with colchicine (p less than 0.002). Our study suggests that colchicine may be useful in avoiding recurrence of pericarditis, although these results need to be confirmed in a larger, double-blind study.

Adolescent↗
PubMed1990

Sudden death in ischemic heart disease.

Sudden death, defined as the death that occurs naturally, unexpectedly and instantaneously or within the first hour of the onset of premonitory symptoms, is one of the most important challenge of the modern cardiology. This is due to both, its elevated incidence (400,000 to 500,000 cases per year in United States alone) and its dramatic presentation (many of the victims are relatively young and have an acceptable quality of life). We have studied de Holter tapes of 233 patients who died suddenly and we can demonstrate that 80% of cases were due to ventricular tachyarrhythmias (ventricular fibrillation 60% and torsades de pointes 20%) and the rameinens 20% were due to bradyarrhythmias. It is well known that ischemic heart disease is the leading cause of sudden death, being responsible for more than 80% of cases. In the present article we will analyze the relationship between sudden death and the different types of ischemic heart disease: stable angina pectoris, unstable angina pectoris, acute myocardial infarction and postinfarction and silent myocardial ischemia.

Angina Pectoris↗