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Biomedical subjects

J H BARON

Publications and source records attributed to J H BARON.

At least 19 recordsLinked to original sources
PubMed1963

Studies of basal and peak acid output with an augmented histamine test.

On the basis that the most repeatable measurement of acid output of the stomach is the peak half hour after an augmented dose of histamine, the author suggests a modification of the Kay test, including titration of the gastric juice to neutrality and measurement of the chloride concentration. The aspiration tube was sited fluoroscopically. It is suggested that the ;peak half hour' should be substituted for the period 15-45 minutes after administration of histamine. This modification is supported by the presented data. It should be noted, however, that the titration technique has also been modified. The ranges of basal and maximum gastric secretion (volume, acidity, acid output, parietal and non-parietal components) in 20 normal males and 20 normal females are presented and analysed for differences of age and sex. Both basal and maximum (histamine stimulated) gastric secretion declined with age, more so in women than in men. ;Maximum' gastric secretion was greater in men than in women, especially in older subjects.

Chlorides↗
PubMed1963

AN ASSESSMENT OF THE AUGMENTED HISTAMINE TEST IN THE DIAGNOSIS OF PEPTIC ULCER. CORRELATIONS BETWEEN GASTRIC SECRETION, AGE AND SEX OF PATIENTS, AND SITE AND NATURE OF THE ULCER.

Patients with peptic ulcer, radiologically negative dyspepsia, and gastric carcinoma have been studied with the modified augmented histamine test described in the previous paper. For each disease a range of values is presented and compared with the normal range, taking account of age and sex. The test may be of diagnostic value because comparison of an observed result with the ranges presented may show that a disorder, for example duodenal ulcer, is almost certainly present or almost certainly not present. Thus, in duodenal ulcer about half the values of peak acid output were above the normal range, and there was a threshold figure for peak acid output below which patients with duodenal ulcer were not found. There was a gradient for peak acid output in patients with ulcers at different sites so that ulcers in the body of the stomach < near the angulus < prepyloric < duodenal ulcers. Normal acid output did not exclude carcinoma of the stomach. Abnormally high basal or peak acid output in patients with dyspepsia but negative barium meals may suggest the presence of peptic ulceration.

Adult↗
PubMed1962

Colonic irritability due to a mercurial bacteriostat in retention enemata.

These observations show that thiomersal, used as a bacteriostatic agent for retention enema solutions, irritates the colon. Investigations leading to the choice of a non-irritant bacteriostatic agent are described. The presence or concentration of sodium chloride in the solution does not seem to be important.

Colitis↗