Biomedical subjects

J H Bae

Publications and source records attributed to J H Bae.

57 records · Page 4Linked to original sources

PubMedDate not supplied

Doxorubicin cardiotoxicity: response of left ventricular ejection fraction to exercise and incidence of regional wall motion abnormalities.

Gated radionuclide ventriculograms were performed to evaluate cardiac function in 53 patients who received doxorubicin treatment for various malignancies (mean dose: 449 +/- 128 mg/m2 BSA). In fourteen patients (Group I) function was evaluated before and after treatment; there was a significant decrease of resting left ventricular ejection fraction after therapy (p less than 0.001). Twenty-two patients (Group II) had serial studies during treatment which also showed a significant fall of resting left ventricular ejection fraction (p less than 0.001). Eighteen patients in Groups I and II had supine exercise studies. A normal exercise response was maintained in the majority of patients. Exercise testing added little to the diagnostic performance when compared to serial resting studies. We found regional wall motion abnormalities (mild apical hypokinesis) at rest by visual inspection in 33 of 36 Group I and Group II patients who had received doxorubicin. In the baseline or initial study, only 4 of these patients demonstrated WMA. In 18 Group I and II patients who were exercised, 3 had wall motion abnormalities during the initial study. All of these patients demonstrated wall motion abnormalities at rest after the second study, however only 7 of 18 demonstrated abnormalities during the exercise study. The results indicate that resting left ventricular ejection fraction declines after doxorubicin treatment. Exercise radionuclide angiography may not increase diagnostic accuracy for the detection of doxorubicin related cardiotoxicity. Regional wall motion abnormalities occur with a relatively high incidence following doxorubicin therapy, more readily detectable at rest. However, the exercise study can distinguish doxorubicin related wall motion abnormalities from those due to coronary artery disease.

Adolescent↗

PubMedDate not supplied

[A study on the effect that rehabilitation education influence on the knowledge attitude and practice of public health nurse].

The home visiting health nurses are important man-power who can serve various and persistent rehabilitation care to disabled person in community. The Community Based Rehabilitation project (CBR) of national rehabilitation center have been carried out from 1995. As a part of that project national health center performed rehabilitation education program for home visiting health nurses. The purpose of this study is to analysis the effect of this education. In the first stage all of those groups were educated for two weeks in national rehabilitation center. But only two group nurses, one is in a urban and the other in a rural community, have been educated continually in the field through discussing rehabilitation care case study. The data in this study were gathered from three group health nurses and analysed by SAS computer program. The results about knowledge, attitude and practice changes of the three group nurses were as follows. 1. In the pre education state the mean point of all nurses' attitude for rehabilitation was 59, but in the post education state that was 90. The difference between pre and post attitude is very significant (t = -14.1, p < 0.0001). 2. In the pre education state the mean point of all nurses' knowledge for rehabilitation was 45, but in the post education state that was 78. The difference between pre and post knowledge is very significant (t = -12.7, p < 0.0001). 3. In the pre education state the mean point of all nurses' practice for rehabilitation care was 37, but in the post education state that was 62. The difference between pre and post practice is very significant (t = -7.3, p < 0.0001). 4. In practice point, the two group nurses who have been educated continuously were superior to the other (t = -3.9, p < 0.001). 5. All points between the urban and rural nurses were no significant differences (p > 0.1). 6. All changes of the attitude, knowledge and practice did not affected by age (F = 0.58, p > 0.1), professional career (F = 0.61, p > 0.1), educational background (F = 0.97, p > 0.1).

Education, Nursing, Continuing↗

PubMedDate not supplied

A genetic study of dentin growth in the mandibular second and third molars of male mice.

Although the influence of genetic and environmental factors on the completed crown size of mandibular molars in mice is well known, such influence on the growth process of the mandibular second and third molars of mice has not yet been clarified. The purpose of the present study is to examine the growth pattern of the dentinal formation and evaluate the relative contributions of both genetic and environmental factors to longitudinal dentin formation by the use of the partial diallel cross-genetic approach, the time-marking method and a computerized image measurement system. The following results were obtained: 1) the onset of dentinal formation in the second molar was on the 6-9th day after birth, while that of the third molar was on the 9-12th day after birth; 2) the best fitted growth curve of the dentinal formation for the first molar was the fifth order polynomial equation, while for the second molar the fourth order polynomial equation was best, and for the third molar the third order polynomial equation was best; 3) maternal effect strongly influenced the second and the third molar dentin growth at an early stage of postnatal growth. Thus, it could be concluded that the dentinal formation growth pattern differed among the three kinds of mouse molars while maternal environmental factors, in addition to genetic factors, played an important role in the mouse second and third molar dentin growth during the early stage of postnatal growth.

Analysis of Variance↗