Biomedical subjects

J H Beuzeron-Mangina

Publications and source records attributed to J H Beuzeron-Mangina.

7 recordsLinked to original sources

PubMed2000

Event-related brain potentials to Memory Workload and 'Analytical-Specific Perception' (Mangina-test) in patients with early Alzheimer's Disease and in normal controls.

Our previous research with intra-cerebral event-related potentials in conjunction with an original Memory Workload Paradigm has shown that significant load effects for the N4 latency were found only for both amygdalae and the left posterior hippocampus as well as for both anterior neo-cortical regions of the temporal gyri. These same structures are also affected in Alzheimer's Disease. Therefore, based on our previous intra-cerebral findings, our present research was to use our novel Memory Workload Paradigm in conjunction with surface ERPs as neurophysiological markers to tap cerebral regions and functions involved in memory disorders pertaining to early Alzheimer's Disease as opposed to normal memory processes in age-matched normal control subjects. Moreover, the Mangina-Test which measures varying degrees of 'Analytical-Specific Visual Perception' was individually administered to all patients and controls in separate sessions. Results indicate that for the early Alzheimer's Disease group, a significant main effect for memory load was found for the P400 amplitude (F(3,30)=4.52, P<0.02) which was absent in the normal group. In particular, the P400 amplitude was significantly higher on posterior head regions for patients with early Alzheimer's Disease as opposed to age-matched normal subjects (F(7,140)=3.54, P<0.03) which distinguished both groups (F(1,20)=6. 13, P<0.03). For the P400 latency, a significant memory load effect was present only for the normal group (F(3,30)=11.26, P<0.01). The Mangina-Test performance clearly differentiated both groups (F(1, 19)=105.85, P<0.001). The present data provide the first valuable evidence that ERPs to our novel Memory Workload Paradigm are sensitive neurophysiological diagnostic markers which delineate the early clinical brain irregularities underlying early Alzheimer's Disease as opposed to the normal memory processes of age-matched normal subjects. In addition, their use could be valuable for the objective clinical follow-up of therapeutic interventions in early Alzheimer's Disease.

Aged↗

PubMed2000

Event-related brain potentials, bilateral electrodermal activity and Mangina-Test performance in learning disabled/ADHD pre-adolescents with severe behavioral disorders as compared to age-matched normal controls.

The most frequently encountered developmental problems of learning disabilities/ADHD often co-exist with severe behavioral disorders. As a direct consequence, this condition opens the way to delinquency, school drop-out, depression, suicide, substance abuse, work absenteeism, and other psycho-social complications. In this paper, we are presenting a selective overview of our previous research and its clinical applications in this field as it relates to our present research data pertaining to the effects of our original Memory Workload Paradigm on the event-related brain potentials in differentiating normal and pathological pre-adolescents (learning disabled/ADHD with concomitant severe behavioral disorders such as oppositional and conduct). In addition, it provides data on the bilateral electrodermal activity during cognitive workload and Mangina-Test performance of pathological and normal pre-adolescents conducted in separate sessions. The results of our present research indicate that a significant memory load effect for the P450 latency (F(3,27)=4.98, P<0.01) and the P450 amplitude (F(3,27)=3.57, P<0.05) was present for normal pre-adolescents which was absent in pathological pre-adolescents. Moreover, enhanced N450 ERP amplitudes to our Memory Workload Paradigm in pre-frontal and frontal regions clearly differentiated normal from pathological pre-adolescents (F(1, 18)=12.21, P<0.004). Furthermore, significant differences between normal and pathological groups were found in bilateral electrodermal activity (F(1,18)=23.86, P<0.001) and on the Mangina-Test performance (F(1,18)=75.35, P<0.001). Our present research findings provide an original and valuable demonstration of an integrative and effective clinical psychophysiological application of central (ERPs), autonomic (bilateral electrodermal activity) and neuro-psychometric aspects (Mangina-Test) which characterize normal and pathological pre-adolescents and underpin the neurophysiological basis of learning disabled/ADHD with severe behavioral disorders as opposed to normal subjects.

Attention Deficit Disorder with Hyperactivity↗

PubMed1992

Identification and standardization of bilateral electrodermal parameters of learning abilities and disabilities.

Data are presented for identified and standardized bilateral electrodermal parameters of normal subjects with learning abilities and those with learning disabilities during cognitive workload in three different sessions. The electrodermal parameters are presented in terms of specific mumhos and represent the first identification and standardization of human abilities and disabilities. It was found that normal subjects had an electrodermal activity level which ranged between 6.5-8.5 mumhos bilaterally. Furthermore, 15 sub-groups of subjects with learning disabilities were identified based on their Left and Right electrodermal activity levels. They could be grouped under three main categories: (1) those subjects with lower than 5.01 mumhos Left and/or Right electrodermal activity level; (2) those with higher than 10.1 mumhos Left and/or Right activity level; and (3) those with mixed electrodermal activity having lower than 5.01 mumhos Left and/or Right activity in one session and higher than 10.1 mumhos activity in another session. These identified and standardized parameters have clinical implications and applications for the electrophysiological evaluation and psychophysiological treatment of learning disabilities.

Adolescent↗

PubMed1992

Psychophysiological treatment for learning disabilities: controlled research and evidence.

Research data are presented on the effects of a psychophysiological treatment method for learning disabilities. A total of 238 subjects with learning disabilities were selected based on their school records. Of these, 105 received the full treatment which consisted of the manipulation and maintenance of bilateral electrodermal activity between 6.5-8.5 mu mhos simultaneously combined with increasingly complex perceptual tasks (Mangina, 1981a, b, c; Mangina and Beuzeron-Mangina, 1988). Another 133 subjects with learning disabilities were assigned into four different conditions: (a) classmate controls; (b) only attachment of electrodes; (c) only optimal activation; (d) only perceptual stimulation. Evidence for the effectiveness of the treatment method was found based on different experimental conditions which are presented in this paper. ANOVA and multiple comparison tests indicate that beneficial effects were only obtained by the administration of the full treatment method and were significant at all three time intervals investigated (P less than 0.001). The evidence supports that the treatment method has induced a 'synergistic simultaneity' which is required by the brain both in terms of its bilaterally 'optimal' physiological activation and the appropriate quality of incoming stimulation in order to produce a beneficial neural integration.

Acoustic Stimulation↗

PubMed1988

Learning abilities and disabilities: effective diagnosis and treatment.

An integrated theoretical and methodological framework is presented for the effective diagnosis and treatment of varying degrees of learning abilities and disabilities. This methodology is based upon: (1) the degrees of 'analytical-specific perceptual skills' as measured by the Mangina test; (2) the identification of standardized physiological activation level parameters; (3) a standardized psychophysiological therapeutic treatment procedure (Mangina method) of 'optimal' physiological activation simultaneously combined with 'analytical-specific perceptual stimulation'.

Adolescent↗

PubMedDate not supplied

Direct electrical stimulation of specific human brain structures and bilateral electrodermal activity.

We are presenting data of research conducted for the first time with human subjects in whom specific intracerebral sites were electrically stimulated through intracerebral electrodes with the concomitant recording of bilateral electrodermal activity. Direct electrical stimulation of specific intracerebral structures for which electrodermal responses were analyzed were the amygdalae, the anterior and posterior hippocampi, the anterior cingulate gyri, the frontal cortical convexities and the mid-region of the second temporal gyri, bilaterally. ANOVA data (side stimulated x stimulation intensity x hand) have shown that significant main effects were found for side stimulated and stimulation intensity for limbic structures only. These results provide strong evidence that human bilateral electrodermal activity is under strong ipsilateral control when limbic structures are stimulated. Moreover, with the stimulation of cortical sites, either absence of response or weak ipsilateral, contralateral, or bilaterally equal influences seem to be operative in the elicitation of bilateral electrodermal activity.

Adult↗

PubMedDate not supplied

Intracerebral event-related potentials during memory workload.

The goals of this research were to use an original Memory Workload Paradigm with visually presented words and to explore the following points: (1) With depth electrodes, stereotaxically implanted in intracerebral structures bilaterally (amygdala, anterior hippocampus, posterior hippocampus, orbital-frontal, anterior cingulate gyrus and cortical areas) to delineate brain structures involved in this memory workload task. (2) To investigate whether a memory load effect can be demonstrated on the latencies and amplitudes of the late components of intracerebral event-related potentials (ERPs). (3) If a load effect is present, do intracerebral ERP latencies and amplitudes vary as a function of memory set size? The analysis of intracerebral ERPs revealed that a negative waveform with a maximum amplitude around 400 ms was the component which was significantly involved in memory workload tasks. Significant load effects for the N4 latency were found in both amygdalae and the left posterior hippocampus, as well as both anterior regions of the second temporal gyri (p < 0.01). The intracerebral N4 latency varied linearly as a function of set size while the amplitude varied quadratically for the right amygdala and the left posterior hippocampus (p < 0.05). The results support the conclusion that the Memory Workload Paradigm provides the possibility to use memory load effect on ERPs as a marker to identify which intracerebral structures are predominantly involved in memory functions.

Adult↗