PubMed Health⌕ Search

Biomedical subjects

J H Exner

Publications and source records attributed to J H Exner.

5 recordsLinked to original sources
PubMed1988

Bioremediation of chemical spills.

It is evident from the data collected to date that substantial progress was made in the remediation of the site prior to the shutdown of the bioreclamation system. Extrapolation of the data suggests that completion of the project was imminent. Further remediation at the site, including the possibility of expanding the original area treated with in situ bioreclamation, is pending further definition of the new sources of contamination. The success of the two projects described here demonstrates the efficacy and potential of enhanced bioreclamation in remediating contamination problems both in soils and in groundwater.

Alkalies↗
PubMed1984

Isotretinoin therapy for acne: results of a multicenter dose-response study.

One hundred fifty patients with treatment-resistant nodulocystic acne were entered into a double-blind clinical study. Three different dosing levels (0.1, 0.5, 1.0 mg/kg/day) were used in equal-sized groups. In addition to the clinical response, the clinical side effects, the laboratory abnormalities, and the duration of the induced remissions were evaluated with each dose of the drug. There was a highly significant clinical response to treatment with all three dosages of isotretinoin. There was no significant difference in the clinical response between dosages. However, 42% of the patients who received 0.1 mg/kg/day of isotretinoin required retreatment with the drug. This finding, coupled with only minor differences in the clinical side effects and the laboratory abnormalities, indicates that higher dose levels of isotretinoin are indicated for treatment of nodulocystic acne.

Acne Vulgaris↗
PubMed1983

Pyogenic granuloma-like acne lesions during isotretinoin therapy.

Three male patients with severe nodulocystic acne were treated with oral isotretinoin in a dosage of 0.5 to 1.0 mg/kg/day. A flare of their disease developed, characterized by an inflammatory, hemorrhagic, pyogenic, granuloma-like response of previously crusted acne lesions. This reaction occurred between the sixth and ninth weeks of treatment and was confined entirely to the chest and back. The severity of the reaction prompted the administration of oral prednisone and, in two cases, the discontinuation of isotretinoin therapy. In one patient, pyoderma gangrenosum developed on the thigh. The exact incidence of this pyogenic, granuloma-like reaction to isotretinoin is unknown, although we have seen it in three of 66 patients with nodulocystic acne treated with this drug. The cause of the reaction is unknown, but it may be due to the increased skin fragility and vascular proliferation known to be induced by isotretinoin.

Acne Vulgaris↗
PubMedDate not supplied

Primary syphilis following a human bite.

The case of a 34-year-old man with primary syphilis is described. The lesions developed on his penis 11 weeks after he sustained a human bite in the same area. Oral administration of cephalexin for five days did not prevent the infection buy may have prolonged the incubation period.

Adult↗