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J H Frelon

Publications and source records attributed to J H Frelon.

8 recordsLinked to original sources
PubMed1989

[Hemodynamic effects of clonidine on the fetus and newborn infant].

This study on clonidine action on fetal HR and on BP and HR in newborns during the first 3 days of life was carried out with 10 mother-child couples in comparison with 10 other couples randomly chosen among our patients; in these last couples the mother has not been treated with this oral anti-hypertensive agent during the last 6 months of the pregnancy. According to the results, clonidine doesn't seem to have any negative action on the fetus and newborn.

Adult↗
PubMed1988

Is apalcillin nephrotoxic?

Apalcillin is a new semisynthetic penicillin used as a sodium salt. More than 4,000 patients have been treated with this antibiotic, but increased serum creatinine levels were noted in 18 cases. In 5 of these cases, apalcillin was possibly responsible, and in 13 it was doubtful. We decided to study renal function of normal volunteers treated with 4 g of apalcillin. Three periods were studied: a pretreatment control period of 80 min followed by a treatment period of 60 min and a posttreatment period of 40 min. Inulin and p-aminohippurate (PAH) infusion were continued during all three periods. At the beginning of the treatment period, 2 g of apalcillin was injected as a bolus, followed by infusion of 2 g of apalcillin over 1 h. Urinary volume was measured every 20 min. Creatinine, insulin, and PAH clearances and urinary excretion of sodium, potassium, calcium, and magnesium were calculated for each period. Urinary beta-2-microglobulin excretion was also assessed. Analysis of variance was done. We observed no variation in clearances of creatinine or inulin or in urinary electrolyte output. PAH clearance was significantly decreased during apalcillin infusion. Apalcillin appeared to compete with PAH for proximal tubular secretion but induced no further renal dysfunction.

Ampicillin↗
PubMed1988

[Apalcillin and renal function].

Apalcilline is a new semi-synthetic penicillin. More than 4,000 patients were treated with this antibiotic but an increase level of serum creatinine was noted in 18 cases. Responsibility of apalcilline in this side effect could be possible in 5 cases, doubtful in 13 cases. We decided to study renal function of normal volunteers treated with 4 gr apalcilline. Three periods were realised: a control period (80 min), a treatment period (60 min), a post-treatment period (40 min). Inulin and PAH infusion lasted during all these three periods. After the control period 2 gr apalcilline was injected as a bolus followed by a 2 gr apalcilline perfusion for one hour. Urinary volume was measured every 20 min. Creatinine, inulin, PAH clearances, sodium, potassium, calcium, magnesium urinary excretion were calculated for each period. Urinary B2-microglobulin excretion was also appreciated. Analysis of variance was done. We did not observe any variation of creatinine, inulin clearances or variation of urinary electrolytes output PAH clearance was significantly decreased during alpacilline infusion. Apalcilline seems competitive with PAH for proximal tubular secretion. Nevertheless apalcilline did not induce any more renal dysfunction.

Adult↗
PubMed1986

[Clonidine and treatment of arterial hypertension in the pregnant woman].

From the results of a non-controlled trial about the successful use of clonidine in 14 hypertensive pregnant women on and on the basis of a bibliographical analysis, the investigators studied efficacy and safety of this central antihypertensive drug. This risk-improvement study reveals that clonidine can be prescribed for the treatment for hypertension during pregnancy.

Adult↗
PubMedDate not supplied

[Clonidine and treatment of arterial hypertension in the pregnant female].

From the results of a non-controlled trial about the successful use of clonidine in 14 hypertensive pregnant women on and on the basis of a bibliographical analysis, the investigators studied the efficacy and safety of this central acting antihypertensive drug. This risk-improvement study reveals that clonidine can be safely and advantageously prescribed for the treatment of hypertension during pregnancy.

Adult↗