Biomedical subjects

J H Frese

Publications and source records attributed to J H Frese.

4 recordsLinked to original sources

PubMed1988

[Gallopamil poisoning. Its course and therapy].

About two hours after swallowing 7 g of Gallopamil, a calcium antagonist, with suicidal intent a 32-year-old woman was admitted to hospital in a somnolent state. At that time the systolic blood pressure was about 40 mm Hg, in the presence of a 3 degrees A-V block. Orciprenaline, dopamine and dobutamine, as well as calcium, proved ineffective. Initially massive doses of adrenaline and noradrenaline, and their continued administration over the subsequent 26 hours, succeeded in normalizing the blood pressure and after transitory pacing, terminated, the arrhythmia in the course of 24 hours. About four hours after its intake the plasma gallopamil concentration was 8.4 micrograms/ml, about 100 times the therapeutic range.

Adult↗

PubMed1979

[Pacemaker's twiddler syndrome (author's transl)].

This report demonstrates the results of five observation of the Pacemaker's-twiddler-syndrome, which will not necessarily end in the complete malfunction of the pacemaker unit. Therefore we classify the Pacemaker's-twiddler-syndrome as a partial and a complete form. The partial form is characterized by still effective cardiac stimulation, whereas the complete form can not stimulate the heart muscle because of the retracted electrode. Also methods of early detection and prevention of the Pacemaker's-twiddler-syndrome are discussed.

Aged↗

PubMed1979

[Pharmacological treatment of chronic arterial occlusive disease (author's transl)].

Two thirds of the patients with peripheral arterial occlusive disease have to be treated conservatively, for only up to 30% can be revascularized by operative methods. Using the pharmacological differential treatment the grade of compensation and localization of the obliterative process has to be considered. Ignoring the usual basic therapy (elimination of heart failure and pathological bradycardia, systemic walking-exercise, anticoagulation etc.) intrafemoral long-term application of energetic phosphate (i.e. nucleotid-nucleosid-mixtures) leads to a positive result in nearly two thirds (n = 97 legs) with a degree of II to IV of Fontaine. Whereas the snakes' encyme Ancrod with the effect of defibrination was successful in almost 70% of the patients with arterial insufficiency (n = 45) including the degree II B (painless walking-distance under 100 meters). Energetic phosphates, applied to the arteria femoralis, are most successful in degree II with claudication intermittens. Ancrod should be used respectively for patients with pain during rest. These results are discussed with respect to compensation and localization of arterial occlusive disease, acute and chronic measurements of the hemodynamics by use of Doppler ultrasound and strain gauge plethysmography and with respect to variation of the concentration of the metabolic parameters lactate and pyruvate--the latter when defibrination was performed.

Aged↗

PubMed1978

Ultrastructure of the extracutaneous pigment cells in the plaice (Pleuronectes platessa, L., Teleostei).

The extracutaneous pigment cell system of the plaice (Pleuronectes platessa L.) was examined by light and electron microscopy in selected regions, including two cutaneous regions for comparison. The extracutaneous pigmentation consists of guanocytes and melanocytes with differing distributions within the body. The eyeless side lacks melanocytes. The pigment cells are differentiated as very flat elements with long processes. They display an affinity for loose connective tissue at boundary layers such as the peritoneal epithelium, organ capsules or blood vessels, to which they are parallelly arranged at a very constant distance. In some locations guanocytes are intimately associated with melanocytes forming "reduced chromatophore units". Extracutaneous pigment cells are poor in mitochondria, endoplasmic reticulum, microfilaments, caveolae intracellulares, ribosomes and glycogen granules, all of which are more abundant in cutaneous pigment cells and pigment cells of the eye. In extracutaneous guanocytes the crystals are loosely arranged parallel to the cell surface, in cutaneous guanocytes perpendicular. Cells with rod-like vesicular cisternae are described as "guanoblasts". No single pigment cell was found exhibiting different types of pigment granules. The varying colors of extracutaneous pigmentation arise from varying combinations of guanocytes and melanocytes in addition to the color of the tissue itself.

Animals↗