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J H García

Publications and source records attributed to J H García.

7 recordsLinked to original sources
PubMed1990

Clinical study of 227 patients with lacunar infarcts.

We describe an analysis of 227 patients with lacunar infarcts; 177 were inpatients and the remaining 50 were outpatients. The group comprised 11% of all inpatients with cerebrovascular pathology and 16% of all consecutive inpatients with brain infarcts studied at the Department of Neurology of the Hospital de la Santa Creu i Sant Pau. The main risk factors identified in these patients were arterial hypertension in 164 (72%), diabetes mellitus in 64 (28%), and heart disease in 58 (26%). The most common clinical syndromes were pure motor hemiparesis in 125 (55%), pure hemisensory stroke in 42 (18%), the sensorimotor deficit syndrome in 34 (15%), ataxic hemiparesis in seven (3%), and the dysarthria-clumsy hand syndrome in four (2%); atypical syndromes were observed in 15 patients (7%). Lacunes were demonstrated by computed tomography in 100 patients (44%) and by magnetic resonance imaging in 35 (78%) of the 45 patients in which it was applied. Magnetic resonance imaging was significantly better (p less than 0.001) than computed tomography for imaging lacunes, especially those located in either the pons (p less than 0.005) or the internal capsule (p less than 0.001). After the acute phase, mild or no neurologic disability was detected in 178 patients (78.4%), moderate disability persisted in 48 patients (21.1%), and severe disability was recorded in one case (0.4%). Lacunar infarcts are a clearly defined entity with characteristic clinical features and an excellent short-term prognosis. Magnetic resonance imaging is the current method of choice for demonstrating these small brain lesions.

Age Factors↗
PubMed1989

Fluorescence histochemistry of RNA in human pituitary adenomas.

Acridine orange (AO)-RNA fluorescence was studied histochemically in 9 normal human pituitary glands, in 26 secretory and nonsecretory pituitary adenomas, and in a dysgerminoma. Six adenomas showing immunoreactivity for prolactin showed intense orange-red cytoplasmic fluorescence; 6 other tumours exhibiting immunoperoxidase activity of growth hormone showed less intense AO-RNA fluorescence, and 5 adrenocorticotropic hormone-containing adenomas showed still weaker orange fluorescence. Among the chromophobe adenomas without immunoreactivity for secretory products, 5 had uniformly very weak AO-RNA fluorescence, while in 4 other a few scattered cells with strong AO-RNA fluorescence were detected among the majority of weakly fluorescent cells. The pituitary dysgerminoma contained many cells with strong AO-RNA fluorescence. Electron microscopy of these cases showed good correlation of cytoplasmic concentration of ribosomes with AO-RNA fluorescence of the adenomas. AO is useful as an inexpensive, simple supplementary stain for frozen or paraffin sections of pituitary tumours to infer secretory activity as a correlate of RNA concentration and to demonstrate a secretory potential in some cells of hormonally inactive tumours.

Acridine Orange↗