Biomedical subjects
Publications and source records attributed to J H Goch.
The influence of levamisole on the course of myocarditis was investigated. It was found that levamisole decreased the intensity of subjective symptoms of disease as well as normalised electrocardiographical and immunological changes in greater part of patients.
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The in vitro increase in mitogenic potency of lysosome factors derived from peripheral blood granulocytes of patients with chronic viral myocarditis was observed. These factors inhibited in vitro the Con A-induced suppressor cell activity measured in lymphocytes from healthy persons. The obtained results suggested that these factors may cause disturbances in suppressor cell function in the course of the foregoing disease.
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160 workers, aged 19-60 (average 41.5 years), engaged in the production of prefabricated concrete elements and chronically exposed to ambient humidity and temperature fluctuations underwent preventive clinical immunological examinations. Eighty-seven subjects passed, within recent six months, upper respiratory tract infection. Forty-seven per cent of those who passed the respiratory tract infection exhibited enhanced immunological reaction of cellular type, ability of lymphocytes blastic transformation, the degree of lymphocytes immunoadherence inhibition in the presence of antigens, and lymphocytes B value. The changes in the circulatory system may be conditioned by chronic myocarditis.
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Some T-cell functions in vitro have been studied in 16 healthy persons, 8 patients with past myocarditis, without any circulatory after-effects and in 12 patients with chronic viral myocarditis. Decrease of T-suppressor cell activity and enhanced blastic transformation of lymphocytes induced with allogeneic heart antigens have been observed in patients suffering from myocarditis. In six patients with active inflammatory process of the heart muscle, application of levamisole brought about not only clinical and electrocardiographic improvement but also an increase of suppressor cells activity and diminished blastic transformation induced with the allogeneic heart antigens and a rise of the T-lymphocytes percentage.
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