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Biomedical subjects

J H Hulshof

Publications and source records attributed to J H Hulshof.

At least 19 recordsLinked to original sources
PubMed2003

Auditory rehabilitation of older people from the general population--the Leiden 85-plus study.

BACKGROUND: Very few older people with severe hearing loss use hearing aids to reduce the negative consequences of reduced hearing in daily functioning. AIM: Assessment of a screening test and a standardised auditory rehabilitation programme for older people from the general population with untreated severe hearing loss. DESIGN OF STUDY: Intervention study and qualitative exploration. SETTING: Leiden 85-Plus Study, a prospective population-based study of 85-year-old inhabitants of Leiden, the Netherlands. METHOD: Hearing loss was measured by pure-tone audiometry in 454 subjects aged 85 years. Subjects with hearing loss above 35 dB at 1, 2, and 4 kHz who did not use hearing aids were invited to participate in a standardised programme for auditory rehabilitation. In-depth interviews were held with participants to explore arguments for participating in this programme. RESULTS: Of the 367 participants with severe hearing loss (prevalence = 81%), 66% (241/367) did not use a hearing aid. Three out of four of these participants (n = 185) declined participation in the auditory rehabilitation programme. The most common reason given for not participating was the subjects' feeling that their current hearing loss did not warrant the use of a hearing aid. Subjects who participated in the programme were found to suffer from more severe hearing loss and experienced more hearing disability. Those who did not participate in the programme felt they could cope with their disabilities and considered a hearing aid unnecessary. CONCLUSION: Untreated hearing loss is prevalent among older people from the general population. The majority of older people decline auditory rehabilitation. For these people the use of a hearing aid is not perceived as necessary in order to function on a daily basis. Older people who have expected benefits from a hearing aid have already obtained them, marginalising the benefits of a rehabilitation (and screening) programme.

Aged↗
PubMed1993

Tinnitus suppression by intravenous lidocaine in relation to its plasma concentration.

In a double-blind controlled trial in nine patients with tinnitus we measured the lidocaine plasma concentrations during and after intravenous administration of lidocaine or placebo and scored the level of tinnitus on a visual analog scale. No patient showed any effect during the placebo infusion. Administration of lidocaine resulted in total suppression or suppression to a non-annoying level of tinnitus in five patients, slight suppression but still annoying tinnitus in two patients, and worsening tinnitus in one patient. No effect of lidocaine was observed in one patient. Most relief was obtained at plasma concentrations between 1.5 and 2.5 micrograms/ml. In this concentration range a significant (p < 0.05) effect of lidocaine on tinnitus was observed. However, notable side effects were observed at plasma concentrations greater than 2.0 micrograms/ml. The effect persisted until plasma levels of about 0.5 microgram/ml were reached. A large variability in the effects existed because of variations in lidocaine kinetics and because of the presumed psychologic components of tinnitus.

Adult↗
PubMed1989

Glottic and supraglottic carcinoma: a retrospective comparison of radiotherapy alone with sandwich therapy in 366 patients.

From 1971 through 1982, 442 patients with laryngeal carcinoma were seen at the Leiden University Hospital. They were treated either with radiotherapy alone, sandwich therapy (pre- and postoperative radiotherapy) or by surgery followed by postoperative irradiation. Three hundred and sixty-six patients with glottic or supraglottic tumours could be analysed with respect to two different treatments, complications of treatment and some prognostic factors. Two endpoints of analysis were used: disease-free interval and survival to cancer death. In patients with glottic or supraglottic carcinoma, the survival of patients with advanced disease, treated with radiotherapy only, was worse as compared to the survival of the same category of patients who were treated with sandwich therapy (p less than 0.005). In patients with small glottic tumours, radiotherapy alone was mostly used. In small supraglottic tumours, the survival with both therapy policies was equal. Persistent hoarseness in patients with small glottic tumours, treated with radiotherapy only, is of predictive value for the development of a recurrence (p less than 0.001). There was no influence on prognosis of histological differentiation of the tumour. It appeared that interruption of radiotherapy for more than two days had an adverse effect on survival in patients with glottic carcinoma (p = 0.0001). Finally, the occurrence of second malignancies was analysed. It was found that 19% had a second malignancy. Almost 60% of them were lung cancers.

Aged↗
PubMed1989

The effect of iontophoresis of lignocaine in the treatment of tinnitus.

Lignocaine is the only drug available that suppresses tinnitus when given intravenously, but the mechanism and the site of its action are not well understood. Iontophoresis, a method by which chemical agents may be transported by electrical current from the ear canal throughout the tympanic membrane into the middle ear, could be expected to have a suppressive effect on tinnitus because the drug is brought so close to the cochlea. In the present study none of the 46 patients reported the suppression of tinnitus to a non-annoying level. Neither lignocaine nor any of its metabolites was found in blood sampled during the period of this treatment.

Adult↗
PubMed1989

Large pituitary adenomas with extension into the nasopharynx. Report of three cases with a review of the literature.

Three cases of pituitary adenoma with extension into the nasopharynx and nasal cavity are reported. The occurrence of this rare tumor underscores the need to consider a pituitary tumor whenever a patient presents with rhinologic complaints and destruction of the sellar floor. Epistaxis, although exceptional, may be the first manifestation of a pituitary tumor. Immunohistochemical analysis combined with staining for the pituitary hormones proved to be essential for reaching a definite diagnosis. Magnetic resonance imaging seems to be the modality of choice for differentiation between tumorous and nontumorous sinus obstruction.

Adenoma↗
PubMed1988

A helpful device in cricopharyngeal surgery.

Extramucosal myotomy of the pharyngoesophageal sphincter muscle, ie, the cricopharyngeal muscle, is a widely used therapy for dysphagia due to neurologic diseases. The cricopharyngeal muscle is dissected free via a lateral cervical incision. To cut the muscle fibers it is necessary to expose and to stretch them. A device is developed to make this possible. A light source is brought within a cuffed tube. The tube is inserted in the esophagus with the cuff in the cricopharyngeal sphincter. Inflating the cuff with air causes stretching of the muscle fibers, whereas the light source inside makes all muscle fibers visible. They can be cut carefully, leaving the mucosa intact.

Humans↗
PubMed1988

Dysphagia in inclusion body myositis.

Four elderly patients with inclusion body myositis and dysphagia are described. Dysphagia was the presenting symptom in three, preceding generalised weakness by 1.5 to 7 years. Myotomy of the cricopharyngeal muscle improved the symptoms and signs in 3 of the 4 patients. It is suggested that inclusion body myositis is not an infrequent cause of dysphagia in elderly people, and is amenable to treatment.

Aged↗
PubMed1987

The effect of nicotinamide on tinnitus: a double-blind controlled study.

The vasodilatory drug nicotinic acid is still widely used in the treatment of tinnitus. Although neither the success rate of this drug nor the pharmacokinetic mechanism underlying the supposed suppressive effect on tinnitus is known, it is clear from the literature that the vasodilative effect is not responsible for its effect on tinnitus. In a double blind controlled trial performed in 48 patients, the value of the related drug nicotinamide was assessed and compared with the effect of a placebo. The results obtained with nicotinamide were not better than those observed for the placebo.

Adolescent↗
PubMed1986

The value of flunarizine in the treatment of tinnitus.

The suppressive effect of flunarizine on tinnitus was assessed in a double-blind trial in 50 patients with tinnitus due to various causes. The duration of the study was 6 weeks. Serum levels of the drug were determined. The patient's subjective assessment of the effect was taken as criterion for the evaluation; objective tests were found to be unsuitable for this purpose. Ten of the patients suffered from dizziness as a secondary complaint. For the group as a whole, there was no difference between flunarizine and the placebo with respect to the effect on tinnitus, but in the 10 patients with dizziness as well there was a significant difference in favor of the drug. Conclusions cannot be drawn as to the reason for this divergence, because the number of patients was too small.

Adult↗
PubMed1986

Dose finding of tocainide in the treatment of tinnitus.

A dose finding study was performed for the use of oral tocainide in the treatment of tinnitus. In a single-blind study, increasing doses of tocainide hydrochloride ranging from 0 to 1800 mg and back to 0 mg were administered to 19 patients. Each dose was given for 4 days and the effects as well as the serum concentrations were recorded on the 4th day. In 8 patients the symptoms regressed to a non-troublesome level. In most instances this effect was seen at doses of 900 and 1800 mg, respectively. Side effects were frequent. The most important side effect, which was an absolute indication for termination of the study, was an exanthema that developed in 7 of the patients (37%). Taking into account all side effects observed, it was concluded that no justification exists for doses over 900 mg daily for the treatment of tinnitus. However, in comparison with lidocaine, which can only be given intravenously, the therapeutic score of tocainide is low and in fact tocainide is no satisfactory alternative to lidocaine.

Administration, Oral↗
PubMed1985

The value of tocainide in the treatment of tinnitus. A double-blind controlled study.

We assessed the value of tocainide in the treatment of tinnitus by performing a double-blind controlled trial in which each of 48 patients with annoying tinnitus received either tocainide HC1 900 mg/day or a placebo. Before the trial, the effect of intravenous lidocaine was evaluated in each patient so that both lidocaine and tocainide could be compared in altering tinnitus. We found that tocainide appeared to have no better effect than the placebo, whereas lidocaine suppressed tinnitus in 81% of the patients treated. The mechanisms of action of both drugs as well as their influence on tinnitus are discussed, as are the side effects of tocainide.

Adult↗
PubMed1985

The value of carbamazepine in the treatment of tinnitus.

A double-blind controlled trial on the use of oral carbamazepine in the treatment of tinnitus is reported. The effects of carbamazepine and intravenous lidocaine on tinnitus were compared. Carbamazepine had less effect than the placebo.

Adult↗
PubMedDate not supplied

Vestibular investigations in Meniere's disease.

151 patients with unilateral Meniere's disease were investigated with a vestibular test battery in the interval between vertigo attacks, and the results were compared with those obtained in a control group. In 73.5% of the patients a caloric response reduction of the afflicted ear was observed. The mean caloric response reduction was 34.3%; a major response reduction or a total absence of the caloric response of the afflicted ear was rare. A correlation was found between the amount of caloric response reduction and the duration of the disease. Spontaneous nystagmus was found in 47% of the cases (mean value 3 degrees/sec) and a mainly direction fixed positional nystagmus in 78% (mean value 4.0 degrees/sec). No correlation was found between the mean hearing loss and the magnitude of caloric response reduction on the day of investigation.

Adolescent↗
PubMedDate not supplied

Follow-up vestibular examination in Menière's disease.

A retrospective study was carried out on repeated audio-vestibular examinations in 53 patients with unilateral Meniere's disease, between the vertiginous spells. Most patients showed no change in the caloric response reduction of the afflicted ear in the subsequent tests compared with the first one. These patients had a comparatively long illness duration, a small percentage of fluctuations in the pure tone audiogram and mostly flat or falling type curves. A minority of patients showed an increase in or a fluctuating caloric test reduction. This group consists of patients with a short disease duration, mostly a fluctuating pure tone audiogram and rising or dome-shaped curves. The hearing loss and the caloric test reduction appear to deteriorate mainly in the first years of the disease. A certain parallelism between the course of vestibular and audiological damage seems to be present.

Adult↗
PubMedDate not supplied

The effect of intra-venous lidocaine and several different doses oral tocainide HCl on tinnitus. A dose-finding study.

As part of preliminary studies for an investigation to assess the place of some drugs, including tocainide HCl, in the treatment of tinnitus, the present study was performed to establish the appropriate dose for tocainide. The effect of lidocaine HCl on tinnitus was studied in a double-blind controlled cross-over study in 22 patients. Lidocaine appeared to give significant relief. To select an optimal daily dose for the lidocaine analog tocainide HCl, this drug was administered orally to 19 patients with obstructive tinnitus in seven 4-day periods. This could be done in a single-blind controlled trial. A different dose was given in each period. Comparison of the effect on tinnitus and the associated side effects led to the choice of a daily dose of 900 mg. The effect of lidocaine HCl appeared to have no prognostic value for the effect of tocainide HCl on the tinnitus in the individual patient.

Administration, Oral↗
PubMedDate not supplied

The loudness of tinnitus.

Although tinnitus causes considerable suffering to many patients, its loudness is small in most cases. Traditionally the loudness is measured with a binaural loudness balance procedure. It is stated that when there is recruitment in the ear to which the test tone is presented, the intensity of the test tone is smaller than its loudness. Therefore in the case of recruitment in the ear to which the test tone is presented, the loudness of tinnitus will be underestimated. In this study the loudness in a group with recruitment in the ear to which the test tone was presented was compared with the loudness in a group with a normal ear to which the test tone was presented. The present results show that although recruitment does have a certain effect, it is very small.

Adolescent↗