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Biomedical subjects

J H Jiang

Publications and source records attributed to J H Jiang.

11 recordsLinked to original sources
PubMed2005

Vascular endothelial growth factor gene therapy with intramuscular injections of plasmid DNA enhances the survival of random pattern flaps in a rat model.

The objective of this study was to determine the effects of the naked plasmid DNA encoding vascular endothelial growth factor (VEGF) on the survival of random flaps on rats. Thirty Sprague-Dawley rats whose random flaps were elevated on the back were randomised into three groups of 10 animals each. In the experimental group, the naked plasmid DNA encoding VEGF was injected directly into the panniculus carnosus of the flap. In the two control groups, either control plasmid DNA or physiologic saline was injected. After 7 days, the flaps were evaluated with the following devices: RT-PCR for the expression of VEGF gene, immunohistochemistry for the expression of VEGF protein, histology for vascular density, single photon emission computerised tomography for RBC in the flap, and image analysis for flap survival area. Notably increased expressions of VEGF mRNA and VEGF protein were found in the treatment group. Vascular density was markedly more increased in the treatment group than those in the two control groups (P < 0.01). Compared with the two control groups, the flap treated with VEGF plasmid DNA showed a more significantly enhanced tissue viability: 87 +/- 5 versus 47 +/- 6% for the control plasmid DNA group and 46 +/- 5% for the saline group (P < 0.01). Our results indicated that the VEGF gene therapy was able to enhance the survival of random pattern flaps by inducing angiogenesis.

Animals↗
PubMed1998

Four-crystal camera at BSRF and its applications.

The four-crystal camera is one of the major items of equipment of the topography station at the Beijing Synchrotron Radiation Facility. The design and some applications of this camera are presented.

Journal Article↗
PubMed1998

The white-radiation dynamic topography experimental system at the BSRF.

A white-radiation dynamic topography experimental system has been established at the BSRF (Beijing Synchrotron Radiation Facility) and is now in operation. Each part of this system is described in this paper, with particular emphasis given to the PC-based online control system, the X-ray video-imaging system and the image-treatment system. Moreover, some of the experimental results, such as the phase transition of KNbO(3) nonlinear optical crystals and of blue bronze charge-density-wave material, are briefly presented.

Journal Article↗
PubMed1998

[Effects of O-(4-ethoxyl-butyl)-berbamine on isolated frog hearts].

AIM: To study the effects of O-(4-ethoxyl-butyl)-berbamine (EBB) on isolated frog heart. METHODS: The isolated frog hearts were prepared with Straub's method; heart contractions were recorded using LMS-2A recorder by tonotransducer. RESULTS: EBB 1-100 mumol.L-1 caused concentration-dependent increase in systolic and diastolic activities, but did not alter the heart rate. EBB 250-500 mumol.L-1 slowed the heart beats and caused ventricular asystole. Cimetidine 10 mumol.L-1 or prazosin 100 mumol.L-1 did not inhibit the positive inotropic action of EBB. Whereas verapamil 0.01 mumol.L-1 antagonized the positive inotropic action of EBB. EBB enhanced positive inotropic action of CaCl2. The action of EBB was slower but longer than caffeine or isoproterenol. At room temperature (21.0 +/- 0.5) degree C, however, the onset of oubain was slower, but the duration of its peak action was longer, than EBB. CONCLUSION: The positive inotropic action of EBB was, at least partially, via promoting the inward current of [Ca2+]o, rather than increasing the intracellular Ca2+ release.

Alkaloids↗
PubMed1994

[Treatment of middle stage arterial embolism through both Fogarty catheter embolectomy and directly pouring thrombolytic agents into artery].

We treated successfully 9 patients with middle stage arterial embolism through both Fogarty catheter embolectomy and directly pouring thrombolytic agents into artery. In all patients the extremities were salvaged and symptoms disappeared. The patients were operated upon 15, 30, 60 hours and 3, 5, 8, 30, 39, 40 days respectively after onset of the disease. The indications for this treatment are dependent on how many hours last between onset and treatment and whether the extremity is gangrened. The main embolus in the greater artery can be removed by Fogarty catheter, while the thrombosis in smaller artery can be resolved by directly arterial luminal pouring thrombolytic agents, so the result is better if the two methods are combined.

Adult↗
PubMed1990

[Observation on ultrastructure of microvasculars in experimental cerebral ischemia].

Ultrastructure changes in microvasculatures were observed in cortical areas of cerebral post-ischemia. Mitochondria distention and endothelial swelling are first damage form in microvasculatures. A large number of pinosomes, damage of continuity of endothelial and basement membrane, membrane-bound intra-luminal bodies, narrow of lumen, compression of perivessels edema were considered as injury basis of microcirculation disturbance and edema in cerebral post-ischemia.

Animals↗
PubMed1989

[Study on carcinogenic activity of several nickel compounds in mice].

This paper reports the result of the tumor in site induced by several nickel compounds in mice. Three nickel compounds (Ni3S2, NiCl, pure nickel powder) were injected separately to the right arm pit subcutaneously (5 mg/mouse). At the end of the 62nd week, the tested mice were sacrificed. Only nickel sulfide induced tumors in the site of injection, the incidence of tumor was 36%. The majority of the tumors were fibrosarcomas, only 2 rhabdomyosarcomas. The tumors might infiltrate into the surrounding tissues, a few metastasized to the liver and/or the lungs.

Animals↗
PubMed1986

[Carcinoembryonic antigen and immunoglobin in gastric juice in the diagnosis of gastric cancer].

Levels of carcinoembryonic antigen (CEA) and immunoglobin (Ig) in gastric juice of 93 patients with benign and malignant gastric diseases were assayed. The CEA level in gastric cancer patients (55.73 +/- 38.26 ng/ml) was obviously higher than that in peptic ulcer (15.51 +/- 12.09 ng/ml) and superficial gastritis (26.96 +/- 20.17 ng/ml). But no significant difference was found between the CEA levels of gastric cancer and chronic atrophic gastritis (48.66 +/- 31.87 ng/ml). Also, elevated CEA was closely correlated to intestinal metaplasia. The positive rate of Ig was significantly higher in gastric cancer (IgG greater than or equal to 185 ug/ml, IgA greater than or equal to 100 ug/ml) than in benign gastric diseases. Although no correlation is present in the CEA and Ig in gastric juice, the combination of these two methods could improve the diagnostic accuracy. We believe that the two assays are worthy for screening gastric cancer from patients with high risk, and for identifying precancerous lesions.

Adult↗