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J H Lockefeer

Publications and source records attributed to J H Lockefeer.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Urinary calculi; the advice of the Health Council].

The recently published advice of the Health Council of The Netherlands concerning urolithiasis can be divided in three chapters i.e. treatment, research and recent developments. The treatment with extracorporeal shockwave lithotripsy is considered the treatment of choice in 95% of patients with urolithiasis. The shockwave treatment has to be performed in centres with specialized know-how and facilities for basic and clinical research. The estimated number of extracorporeal shockwave lithotriptors in The Netherlands necessary for treatment of ca. 5400 patients per year with renal stones who are the most likely candidates for lithotripsy is at six. To prevent recurrent stone-forming in most patients metaphylactic therapy is indicated as well. At the moment lithotripsy of gallstones and treatment of kidney stones by means of lasers are in an experimental stage.

Adult↗
PubMed1986

A comparison of porcine and human thyroid tissue in the assay of thyroid stimulating immunoglobulins.

The central role of Thyroid Stimulating Immunoglobulins (TSI) in the pathogenesis of the hyperthyroidism of Graves' disease has become generally accepted and a wide variety of assays for the detection of these antibodies has been developed. The dependence on the availability of human thyroid tissue makes most of these assays unsuitable for routine clinical use, a problem circumvented by the use of nonhuman thyroid tissue in some TSI assays. We therefore compared porcine and human thyroid tissue in a TSI assay based on in vitro cAMP generation. No major differences in within and between run variation were found and, with some notable exceptions, a reasonable correlation could be demonstrated between the results in both assays (R = 0.89, P less than 0.001). However, the sensitivity of the porcine TSI assay is only 60% of the estimated sensitivity of the human TSI assay. In spite of the practical advantages this porcine TSI assay, and possibly also other TSI assays using non-human thyroid tissue, cannot totally replace human TSI assays. The value of these assays in predicting the outcome of medical treatment of Graves' disease remains to be established.

Animals↗
PubMed1978

A comparative study of two methods of measurement of fractional calcium absorption: results in normal individuals and patients with various disturbances of calcium metabolism.

Two methods of measurement of fractional calcium absorption have been compared in the same individuals. There is a significant correlation between fractional 47Ca absorption as measured with a blood counting method and with an external counting method after intravenous and oral administration of 47Ca (P less than 0.001). Two varieties of the external counting method, namely with intervals of 2 h and 7 days between the i.v. and oral doses, have been compared. In a group of twenty-one patients with chronic renal failure (not on haemodialysis), 47Ca absorption as measured by external counting was significantly lower than in the control group (P less than 0.001). When put on a dialysis programme a group of six patients showed a significant increase of the fractional 47Ca absorption (P less than 0.01).

Absorption↗