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Biomedical subjects

J H Merritt

Publications and source records attributed to J H Merritt.

At least 19 recordsLinked to original sources
PubMed2001

Lack of effect of 94 GHz radio frequency radiation exposure in an animal model of skin carcinogenesis.

Although there is no evidence that electromagnetic energy in the radio frequency radiation (RFR) band is mutagenic, there have been suggestions that RFR energy might serve as either a promoter or co-promoter in some animal models of carcinogenesis. Recent developments in electromagnetic technology have resulted in the manufacture of RFR sources capable of generating frequencies in the millimeter wavelength (MMW) range (30-300 GHz). Because absorption of MMW energy occurs in the skin, it is to be expected that long-term detrimental health effects, if any, would most likely be manifest in the skin. In this study we investigated whether a single (1.0 W/cm(2) for 10 s) or repeated (2 exposures/week for 12 weeks, 333 mW/cm(2) for 10 s) exposure to 94 GHz RFR serves as a promoter or co-promoter in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced SENCAR mouse model of skin carcinogenesis. Neither paradigm of MMW exposure significantly affected papilloma development, as evidenced by a lack of effect on tumor incidence and multiplicity. There was also no evidence that MMW exposure served as a co-promoter in DMBA-induced animals repeatedly treated with 12-O-tetradecanoylphorbol 13-acetate. Therefore, we conclude that exposure to 94 GHz RFR under these conditions does not promote or co-promote papilloma development in this animal model of skin carcinogenesis.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed2000

Effects of high peak power microwaves on the retina of the rhesus monkey.

We studied the retinal effects of 1.25 GHz high peak power microwaves in Rhesus monkeys. Preexposure fundus photographs, retinal angiograms, and electroretinograms (ERG) were obtained to screen for normal ocular structure and function and, after exposure, as endpoints of the study. Histopathology of the retina was an additional endpoint. Seventeen monkeys were randomly assigned to receive sham exposure or pulsed microwave exposures. Microwaves were delivered anteriorly to the face at 0, 4.3, 8.4, or 20.2 W/kg spatially and temporally averaged retinal specific absorption rates (R-SAR). The pulse characteristics were 1.04 MW ( approximately 1.30 MW/kg temporal peak R-SAR), 5.59 micros pulse length at 0, 0.59, 1. 18, and 2.79 Hz pulse repetition rates. Exposure was 4 h per day and 3 days per week for 3 weeks, for a total of nine exposures. The preexposure and postexposure fundus pictures and angiograms were all within normal limits. The response of cone photoreceptors to light flash was enhanced in monkeys exposed at 8.4 or 20.2 W/kg R-SAR, but not in monkeys exposed at 4.3 W/kg R-SAR. Scotopic (rod) response, maximum (combined cone and rod) response, and Naka-Rushton R(max) and log K of scotopic b-waves were all within normal range. Retinal histopathology revealed the presence of enhanced glycogen storage in photoreceptors among sham (2/5), 8.4 W/kg (3/3), and 20.2 W/kg (2/5) exposed monkeys, while enhanced glycogen storage was not observed in the 4.3 W/kg (0/4) exposed group. Supranormal cone photoreceptor b-wave was R-SAR dependent and may be an early indicator of mild injury. However no evidence of degenerative changes and ERG depression was seen. We concluded that retinal injury is very unlikely at 4 W/kg. Functional changes that occur at higher R-SAR are probably reversible since we saw no evidence of histopathologic correlation with ERG changes. Bioelectromagnetics 21:439-454, 2000. Published 2000 Wiley-Liss, Inc.

Absorption↗
PubMed1999

Lack of effects on heart rate and blood pressure in ketamine-anesthetized rats briefly exposed to ultra-wideband electromagnetic pulses.

Fourteen Sprague-Dawley rats were exposed to pulses produced by a Bournlea ultra-wideband (UWB) pulse generator (rise time, 318-337 ps; maximum E field, 19-21 kV/m). Exposures at a repetition frequency of 1 kHz for 0.5 s or to repetitive pulse trains (2-s exposure periods alternating with 2 s of no exposure, for a total of 2 min) resulted in no significant changes in heart rate or mean arterial blood pressure. These results suggest that acute whole-body exposure to UWB pulses does not have a detrimental effect on the cardiovascular system.

Anesthetics, Dissociative↗
PubMed1998

Establishing orally self-administered cocaine as a reinforcer in rats using home-cage pre-exposure.

1. Rats were force-exposed to a cocaine + saccharin solution in their home cage water bottles for five days. They were then given 5 h home-cage access to both cocaine and cocaine-free solutions for 40 days. 2. The subjects consumed large doses of the cocaine solution despite the ad libitum availability of water. 3. The animals were then trained on a task consisting of operant bar pressing rewarded on an intermittent schedule with a liquid cocaine reinforcer. 4. All subjects performed the operant task and consumed doses of cocaine solution which are preferred over water in other paradigms. 5. Levels of responding were significantly reduced in three of four subjects when vehicle was substituted for liquid cocaine as the reward. 6. This demonstrates that orally self-administered cocaine can be used as a reinforcer in rats.

Administration, Oral↗
PubMed1998

Chronic exposure of cancer-prone mice to low-level 2450 MHz radiofrequency radiation.

The purpose of this study was to determine whether chronic, low-level exposure of mammary-tumor-prone mice to 2450 MHz radiofrequency radiation (RFR) promotes an earlier onset (decreased latency), a greater total incidence, or a faster growth rate of mammary tumors. One hundred C3H/ HeJ mice were exposed in circularly polarized waveguides (CWG) for 18 months (20 h/day, 7 days/wk) to continuous-wave, 2450 MHz RFR at a whole body average specific absorption rate (SAR) of 0.3 W/kg; 100 mice were sham exposed. Before exposure, SARs were determined calorimetrically; during experimentation, SARs were monitored by differential power measurement. All animals were visually inspected twice daily and were removed from the CWG cages for a weekly inspection, palpation, and weighing. From the time of detection, tumor size was measured weekly. Animals that died spontaneously, became moribund, or were killed after 18 months of exposure were completely necropsied; tissues were fixed and subjected to histopathological evaluations. Results showed no significant difference in weight profiles between sham-irradiated and irradiated mice. Concerning mammary carcinomas, there was no significant difference between groups with respect to palpated tumor incidence (sham = 52%; irradiated = 44%), latency to tumor onset (sham = 62.3 +/- 1.2 wk; irradiated = 64.0 +/- 1.6 wk), and rate of tumor growth. In general, histopathological examination revealed no significant differences in numbers of malignant, metastatic, or benign neoplasms between the two groups; a significantly greater incidence of alveolar-bronchiolar adenoma in the sham-irradiated mice was the only exception. In addition, survival analysis showed no significant difference in cumulative percent survival between sham and irradiated animals. Thus, results indicate that under the conditions of this study, long-term, low-level exposure of mammary-tumor-prone mice to 2450 MHz RFR did not affect mammary tumor incidence, latency to tumor onset, tumor growth rate, or animal longevity when compared with sham-irradiated controls.

Animals↗
PubMed1998

The older adult with diabetes.

Like their younger counterparts, older adults with diabetes need individualized treatment and educational programs based on personal glucose goals. Although most of the tools and therapies available to younger adults are also appropriate for the elderly, additional considerations and strategies are needed to meet the needs of this population for whom diabetes is a frequent and serious problem. To be effective, the therapeutic approach needs to take into consideration the aging process, other health problems, and the functional, psychosocial, cultural, and educational status of each patient. Along with these considerations, this article provides an overview of the treatment of diabetes for this age group and offers strategies for working with older adults.

Adult↗
PubMed1998

Chronic, low-level (1.0 W/kg) exposure of mice prone to mammary cancer to 2450 MHz microwaves.

In a previous study (Frei et al., Bioelectromagnetics 19, 20-31, 1998), we showed that low-level (0.3 W/kg), long-term exposure of mice prone to mammary tumors to 2450 MHz radiofrequency (RF) radiation did not affect the incidence of mammary tumors, latency to tumor onset, tumor growth rate or animal survival when compared to sham-irradiated animals. In the current study, the specific absorption rate (SAR) was increased from 0.3 W/kg to 1.0 W/kg. The same biological end points were used. One hundred C3H/HeJ mice were exposed in circularly polarized waveguides for 78 weeks (20 h/day, 7 days/week) to continuous-wave, 2450 MHz RF radiation; 100 mice were sham-exposed. There was no significant difference between exposed and sham-exposed groups with respect to the incidence of palpated mammary tumors (sham-exposed = 30%; irradiated = 38%), latency to tumor onset (sham-exposed = 62.0 +/- 2.3 weeks; irradiated = 62.5 +/- 2.2 weeks) and rate of tumor growth. Histopathological evaluations revealed no significant difference in numbers of malignant, metastatic or benign neoplasms between the two groups. Thus long-term exposures of mice prone to mammary tumors to 2450 MHz RF radiation at SARs of 0.3 and 1.0 W/kg had no significant effects when compared to sham-irradiated animals.

Animals↗
PubMed1997

Thresholds of microwave-evoked warmth sensations in human skin.

We measured thresholds for microwave-evoked skin sensations of warmth at frequencies of 2.45, 7.5, 10, 35, and 94 GHz. In the same subjects, thresholds of warmth evoked by infrared radiation (IR) were also measured for comparison. Detection thresholds were measured on the skin in the middle of the back in 15 adult male human subjects at all microwave (MW) frequencies and with IR. Long duration (10-s), large area (327-cm2) stimuli were used to minimize any differential effects of temporal or spatial summation. Sensitivity increased monotonically with frequency throughout the range of microwave frequencies tested. The threshold at 94 GHz (4.5 +/- 0.6 mW/cm2) was more than an order of magnitude less than at 2.45 GHz (63.1 +/- 6.7 mW/cm2), and it was comparable to the threshold for IR (5.34 +/- 1.07 mW/cm2).

Adult↗
PubMed1997

Long-term, low-level exposure of mice prone to mammary tumors to 435 MHz radiofrequency radiation.

The purpose of this study was to determine if chronic, low-level exposure of mice prone to mammary tumors to 435 MHz radiofrequency (RF) radiation promotes an earlier onset, a faster growth rate or a greater total incidence of mammary tumors than in sham-exposed controls. Two hundred female C3H/HeJ mice were exposed for 21 months (22 h/day, 7 days/week) to a horizontally polarized 435 MHz pulse-wave (1.0 micros pulse width, 1.0 kHz pulse rate) RF radiation environment with an incident power density of 1.0 mW/cm2 (SAR = 0.32 W/kg). An additional 200 mice were sham-exposed. Animals that died spontaneously, became moribund or were euthanized after 21 months of exposure were completely necropsied; tissues were subjected to histopathological examinations. Concerning mammary carcinomas, there were no significant differences between the two groups with respect to latency to tumor onset, tumor growth rate and overall tumor incidence. Histopathological examination revealed no significant differences in numbers of malignant, metastatic or benign neoplasms between groups. Survival probability was estimated by the Kaplan-Meier method; no significant difference between groups was noted (Cox's test). Under the conditions of this long-term study, low-level exposure of mice prone to mammary tumors to 435 MHz RF radiation did not affect the incidence of mammary tumors, tumor growth rate, latency to tumor onset or animal longevity when compared to sham-exposed controls.

Animals↗
PubMed1995

No detectable bioeffects following acute exposure to high peak power ultra-wide band electromagnetic radiation in rats.

A wide range assessment of the possible bioeffects of an acute exposure to high peak power ultra-wide band (UWB) electromagnetic radiation was performed in rats. The UWB-exposure consisted of 2 min of pulsed (frequency: 60 Hz, pulse width: 5-10 ns) UWB (bandwidth: 0.25-2.50 GHz) electromagnetic radiation. Rats were examined using one of the following: 1) a functional observational battery (FOB); 2) a swimming performance test; 3) a complete panel of blood chemistries; or 4) determination of the expression of the c-fos protein in immunohistologically-stained sections of the brain. No significant differences were found between UWB- or sham-exposed rats on any of the measured parameters.

Animals↗
PubMed1995

Considerations for human exposure standards for fast-rise-time high-peak-power electromagnetic pulses.

Development of new emitter systems capable of producing high-peak-power electromagnetic pulses with very fast rise times and narrow pulse widths is continuing. Such directed energy weapons systems will be used in the future to defeat electronically vulnerable targets. Human exposures to these pulses can be expected during testing and operations. Development of these technologies for radar and communications purposes has the potential for wider environmental exposure, as well. Current IEEE C95.1-1991 human exposure guidelines do not specifically address these types of pulses, though limits are stated for pulsed emissions. The process for developing standards includes an evaluation of the relevant bioeffects data base. A recommendation has been made that human exposure to ultrashort electromagnetic pulses that engender electromagnetic transients, called precursor waves, should be avoided. Studies that purport to show the potential for tissue damage induced by such pulses were described. The studies cited in support of the recommendation were not relevant to the issues of tissue damage by propagated pulses. A number of investigations are cited in this review that directly address the biological effects of electromagnetic pulses. These studies have not shown evidence of tissue damage as a result of exposure to high-peak-power pulsed microwaves. It is our opinion that the current guidelines are sufficiently protective for human exposure to these pulses.

Animals↗
PubMed1994

Influence of microwave exposure on chlordiazepoxide effects in the mouse staircase test.

To ascertain whether behavioral effects of benzodiazepines are altered by exposure to microwave radiation, we compared the performance of male, Swiss CD1 mice in the staircase test 30 min after pretreatment with chlordiazepoxide (8, 16, and 32 mg/kg, IP) and immediately following a 5-min exposure to microwave radiation (4, 12, and 36 W/kg, continuous wave, 1.8 or 4.7 GHz). In this paradigm, chlordiazepoxide reduction in the number of rears (NR) and number of steps ascended (NSA) is postulated to reflect anxiolytic and sedative drug effects, respectively. In sham-exposed mice, increasing doses of chlordiazepoxide increased NSA without affecting NR, increased NSA and decreased NR, then decreased both NSA and NR. Microwave exposure generally did not alter NSA or NR in mice pretreated with lower doses of chlordiazepoxide. However, in mice pretreated with 32 mg/kg chlordiazepoxide, exposure to 36 W/kg microwave radiation significantly reversed the reductions in NSA and NR at 4.7 GHz but not at 1.8 GHz. These findings indicate that exposure to microwave radiation can selectively alter effects of chlordiazepoxide in this psychopharmacological paradigm.

Animals↗
PubMed1993

The challenges of diabetes and older adults.

Diabetes is a chronic illness that affects a disproportionate number of older adults and members of ethnic minorities. It is an illness that requires long-term active patient participation to maintain metabolic control and challenges both the patient and health care provider. The need for the patient to carry out daily self-care behaviors is no less important simply because the person is older. Older adults, however, experience unique challenges because of the physical and functional changes that may be imposed by the aging process and the prevalence of multiple chronic illnesses and complications. Because diabetes self-care is carried out within the context of all aspects of a person's life, it is important, then, for the health professional to recognize these social, functional, and psychological challenges. All aspects of physical, functional, and psychosocial status need to be taken into account, and diabetes education needs to be provided based on jointly identified goals, interests, abilities, and needs.

Aged↗
PubMed1991

The epidemiology of exposure to electromagnetic fields: an overview of the recent literature.

Epidemiologic studies of exposure to electromagnetic fields (EMF) have been reviewed. Possible links to incidences of cancer and abnormal fetal development have been suggested by some investigators. In general, the results have been inconsistent. There are many deficiencies in the studies, and many questions have been raised about the validity of some of the conclusions proposed. There is currently no definitive evidence of an association between exposure to EMF and the alleged risks. Due to problems and limitations inherent in future studies (misconceptions about exposure levels, uncertainty about field variability, criticisms of surrogate measures), this question is unlikely to ever be answered with certainty. Unfortunately, many highly-publicized accounts of speculative and unsubstantiated claims have caused undue concern among the general public.

Electromagnetic Fields↗