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Biomedical subjects

J H Mulholland

Publications and source records attributed to J H Mulholland.

13 recordsLinked to original sources
PubMed1996

Successful treatment of primary cutaneous Aspergillus flavus infection of the hand with oral itraconazole.

Primary cutaneous Aspergillus flavus infections of the hand are exceedingly rare. Usually, these infections are present in severely immunocompromised patients suffering from lymphoreticular malignancies. The majority of cases result in invasive systemic infections and often culminate in death. We report a case of primary cutaneous A. flavus infection in the hand of a patient immunocompromised only by non-insulin-dependent diabetes, who ultimately was cured of this infection with oral itraconazole.

Administration, Oral↗
PubMed1981

Hemophilus influenzae type B, mediastinitis, cellulitis, bacteremia, and meningitis in an adult.

A 63-year-old woman presented with cellulitis of the upper anterior chest and neck that rapidly extended into an acute mediastinitis. Pleural effusions and meningitis subsequently developed. The infection was due to an ampicillin-susceptible strain of Hemophilus influenzae type B. The patient was treated with and responded to chloramphenicol therapy. No definite predisposing factor could be determined.

Cellulitis↗
PubMedDate not supplied

Treatment of systemic sporotrichosis with ketoconazole.

Infections of deep soft tissues with the dimorphic fungus Sporothrix schenckii are uncommon in humans, and therapy has often required toxic drugs. We report our experience in treating 11 patients who had deep-seated sporotrichosis with ketoconazole, a well-tolerated, orally absorbed antifungal agent. Eight infections involved one or more joints, and three involved thoracic, cervical, and widespread cutaneous sites, respectively. For eight patients all evidence of infection resolved during therapy. Sustained remissions (6 months to 5 years) were noted for six patients after the discontinuation of all therapy and for an additional patient 4 years after the initiation of ketoconazole treatment. Durable responses were associated with prolonged treatment with 400-800 mg of ketoconazole daily. Our favorable experience suggests that oral therapy with ketoconazole may benefit other patients with systemic sporotrichosis.

Adult↗